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Browse our Prolactin Receptor Proteins (PRLR)

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Prolactin Receptor Proteins (PRLR)
On are 67 Prolactin Receptor (PRLR) Proteins from 12 different suppliers available. Additionally we are shipping Prolactin Receptor Antibodies (112) and Prolactin Receptor Kits (11) and many more products for this protein. A total of 198 Prolactin Receptor products are currently listed.
AI987712, DKFZp469D061, hPRLrI, Pr-1, Pr-3, PRL-R, PRLR, Prlr-rs1, PRLRb, RATPRLR, tprlr
list all proteins Gene Name GeneID UniProt
PRLR 5618 P16471
PRLR 19116 Q08501
PRLR 24684 P05710

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Prolactin Receptor Proteins (PRLR) by Origin

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Top referenced Prolactin Receptor Proteins

  1. Mouse (Murine) Prolactin Receptor Protein expressed in Human Cells - ABIN2007816 : Somers, Ultsch, De Vos, Kossiakoff: The X-ray structure of a growth hormone-prolactin receptor complex. in Nature 1994 (PubMed)
    Show all 4 references for ABIN2007816

  2. Human Prolactin Receptor Protein expressed in Human Cells - ABIN2002497 : Fuh, Wells: Prolactin receptor antagonists that inhibit the growth of breast cancer cell lines. in The Journal of biological chemistry 1995 (PubMed)
    Show all 4 references for ABIN2002497

  3. Rat (Rattus) Prolactin Receptor Protein expressed in Human Cells - ABIN2009107 : Kline, Roehrs, Clevenger: Functional characterization of the intermediate isoform of the human prolactin receptor. in The Journal of biological chemistry 2000 (PubMed)
    Show all 4 references for ABIN2009107

More Proteins for Prolactin Receptor Interaction Partners

Turkey Prolactin Receptor (PRLR) interaction partners

  1. both species had very similar patterns of PRL (show PRL Proteins) release and expression of PRLR mRNA, and no major differences were observed between turkey or chicken embryos

Human Prolactin Receptor (PRLR) interaction partners

  1. The prolactin receptor is constitutively expressed on regulatory T and effector T cells in systemic lupus erythematosus patients, and this expression is higher than in healthy individuals.

  2. There is a possible role for PRLR in the progression of cervical cancer.

  3. PRL (show PRL Proteins)-PRLR can escalate the impact of breast cancer on bone metastasis and the presence of PRLR in the tumor microenvironment of breast cancer bone metastasis has the potential to modulate the microenvironment to induce lytic osteoclast formation.

  4. Study shows that position 146 plays a central role in directing intrinsic properties of the PRLR, including extracellular domain folding, PRL (show PRL Proteins)-responsiveness, and ligand-independent activity of the receptor.

  5. Data suggest that (1) cell membrane/lipid bilayer binding of PRLR and (2) tyrosine phosphorylation of PRLR intracellular domain are independent.

  6. long PRLR plays an important role in breast cancer metastasis.

  7. a residue quartet in the extracellular membrane proximal domain of the homodimeric cytokine receptor (show EBI3 Proteins) prolactin receptor is a key regulator of intracellular signaling discrimination

  8. PRL (show PRL Proteins) induced transient signaling pathways in neurons and modulated ion channels. [review]

  9. exposure to prolactin (show PRL Proteins) increases TNF-alpha (show TNF Proteins) release from CD14 (show NDUFA2 Proteins)(+) monocytes of rheumatoid arthritis patients, which can be abolished by PRLR gene silencing or treating with MAPK (show MAPK1 Proteins) inhibitor.

  10. Major changes in prolactin receptor conformation and dimerization affinity are triggered by single mutations in critical regions of D1.

Mouse (Murine) Prolactin Receptor (PRLR) interaction partners

  1. Of the four placenta-specific, Prl (show PRL Proteins)-related hormones that have been shown to interact with the Prlr, their gene expression localizes to different endocrine cell types

  2. Prolactin (show PRL Proteins) transport into mouse brain is independent of prolactin receptor.

  3. Prolactin receptor was upregulated in proximal kidney tubule cells of mice with cardiac disease.

  4. This study showed in knockout mice showed no effect of PRL (show PRL Proteins) and PRL-R gene ablation on heat and cold hyperalgesia in male mice, while heat hyperlgesia were reduced 3-72 h post-surgery in female PRL (show PRL Proteins) and PRL-R knockout mice

  5. The in utero environment of the Prlr(+/-) mother confers long-term changes in the pancreatic islets of her offspring such that when the offspring themselves became pregnant, they cannot adapt to the increased insulin (show INS Proteins) demands of their own pregnancy.

  6. results provide direct genetic evidence that PRLR affects energy balance and metabolic adaptation in rodents via effects on brown adipose tissue differentiation and function

  7. Germline knockout of prolactin (show PRL Proteins) or its receptor has failed to reveal a key role for prolactin (show PRL Proteins) signaling in mouse prostate physiology.

  8. Data suggest that PRL (show PRL Proteins) stimulates the Prlr gene expression through the transcriptional activation of mE1 (show ME1 Proteins)(4) first exon, leading to increases in the long- and short-form variants of Prlr mRNA in the murine choroid plexus.

  9. These results demonstrate important contextual aspects of PRL (show PRL Proteins)-PRLR interactions with implications for the analysis of the role of PRL (show PRL Proteins) in breast cancer.

  10. Data suggest that prolactin (show PRL Proteins) is involved in regulation of prolactin receptor expression and maintenance of physiological cell renewal in anterior pituitary. Prolactin/prolactin (show PRL Proteins) receptor signaling may be involved in regulation of pituitary gland size.

Horse (Equine) Prolactin Receptor (PRLR) interaction partners

Pig (Porcine) Prolactin Receptor (PRLR) interaction partners

  1. Alternative splicing of transcripts from nine first exons of the porcine PRLR (pPRLR) gene are differentially expressed in various tissues.

  2. The effects of prolactin receptor and beta-casein (show CSN2 Proteins) genotype on the nutritive value of sow milk are reported.

  3. PRLR was identified as down-regulated in the oviduct of immotile short tail sperm (ISTS) homozygous sows. The methylation pattern of the PRLR gene region appeared unaffected.

  4. Associations between genotypes of the prolactin receptor (PRLR) gene and swine reproductive, growth and meat traits were determined.

  5. A prolactin receptor short mRNA sequence that is encoded by exon 11 within the pPRLR gene is expressed most abundantly in several tissues known to be prolactin (show PRL Proteins) targets in pigs. The pPRLR-SF acts as a dominant negative to the pPRLR-LF.

  6. Results showed that the effects of FSHb (show FSHB Proteins), ESR (show ESR1 Proteins), and PRLR genes were significant in the Tibet pig population, and the effective genotypes of the three genes for reproductive traits were BB, BB, and AA, respectively.

  7. found associations between PRLR genotype and ejaculate volume, sperm concentration, percentage of live sperm, and number of live sperm in the ejaculate

  8. A report of greater than expected levels of amino acid variability within the intracellular domain of the porcine PRLR, which have been associated with differences in ovulation in sows and the preweaning survivability of piglets is presented.

  9. Data showed that sows with genotype AB in PRLR gene had a significantly higher frequency of lateral-lying-to- other-posture trait and percentage of sow-terminated nursing trait than sows with the AA and BB genotypes.

  10. The results showed that the polymorphic sites of both PRLR and RBP4 (show RBP4 Proteins) genes are closely related to litter size traits.

Cow (Bovine) Prolactin Receptor (PRLR) interaction partners

  1. The presence and localization of prolactin receptor are consistent with expression data reported for other species, and the presence of PIP (show PIP Proteins) and prolactin (show PRL Proteins) in seminal fluid is consistent with data generated in humans.

  2. This study revealed for the first time that the PRLR gene is a promising candidate gene that affects growth traits in cattle.

  3. determination of the effects of exposure to different lengths of daylight during the dry period on circulating PRL (show PRL Proteins) and PRL (show PRL Proteins) receptor mRNA expression in lymphocytes and mammary tissue during the transition to lactation

Prolactin Receptor (PRLR) Protein Profile

Protein Summary

This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer.

Alternative names and synonyms associated with Prolactin Receptor (PRLR)

  • prolactin receptor (prlr-a)
  • prolactin receptor (prlr-b)
  • prolactin receptor (PRLR)
  • prolactin receptor (prlr)
  • prolactin receptor (Prlr)
  • prolactin receptor (PR)
  • AI987712 protein
  • DKFZp469D061 protein
  • hPRLrI protein
  • Pr-1 protein
  • Pr-3 protein
  • PRL-R protein
  • PRLR protein
  • Prlr-rs1 protein
  • PRLRb protein
  • RATPRLR protein
  • tprlr protein

Protein level used designations for Prolactin Receptor Proteins (PRLR)

prolactin receptor , prolactin receptor-like , PRL-R , hPRL receptor , secreted prolactin binding protein , prolactin receptor related sequence 1 , lactogen receptor , prolactin receptor long form , cPRLR , equates to base 1078-1204 of D13154 , prolactin receptor b

373618 Xenopus laevis
373812 Xenopus laevis
461925 Pan troglodytes
479363 Canis lupus familiaris
554331 Ovis aries
699369 Macaca mulatta
778003 Takifugu rubripes
100009321 Oryctolagus cuniculus
100126248 Meleagris gallopavo
100294567 Pongo abelii
100401704 Callithrix jacchus
100481840 Ailuropoda melanoleuca
100534586 Oreochromis niloticus
5618 Homo sapiens
19116 Mus musculus
24684 Rattus norvegicus
100053793 Equus caballus
414916 Sus scrofa
100009046 Oryctolagus cuniculus
281422 Bos taurus
395660 Gallus gallus
443020 Ovis aries
100136609 Oncorhynchus mykiss
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