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Browse our anti-PTPN6 (PTPN6) Antibodies

Full name:
anti-Protein-tyrosine Phosphatase 1C Antibodies (PTPN6)
On www.antibodies-online.com are 185 Protein-tyrosine Phosphatase 1C (PTPN6) Antibodies from 26 different suppliers available. Additionally we are shipping PTPN6 Proteins (19) and PTPN6 Kits (15) and many more products for this protein. A total of 227 PTPN6 products are currently listed.
Synonyms:
DRPLA, hcp, Hcph, HPTP1C, me, motheaten, PTP-1C, Ptp1C, Ptph6, SH-PTP1, SHP, Shp-1, SHP-1L, SHP1
list all antibodies Gene Name GeneID UniProt
PTPN6 23957 Q62227
PTPN6 5777 P29350
PTPN6 116689 P81718

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Most Popular Reactivities for anti-PTPN6 (PTPN6) Antibodies

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anti-Mouse (Murine) PTPN6 Antibodies:

anti-Human PTPN6 Antibodies:

anti-Rat (Rattus) PTPN6 Antibodies:

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Top referenced anti-PTPN6 Antibodies

  1. Human Monoclonal PTPN6 Primary Antibody for IHC (p), IP - ABIN264440 : Bittorf, Seiler, Zhang, Jaster, Brock: SHP1 protein tyrosine phosphatase negatively modulates erythroid differentiation and suppression of apoptosis in J2E erythroleukemic cells. in Biological chemistry 2000 (PubMed)
    Show all 5 references for ABIN264440

  2. Dog (Canine) Monoclonal PTPN6 Primary Antibody for IF, IP - ABIN967766 : Duchene, Schanstra, Pecher, Pizard, Susini, Esteve, Bascands, Girolami: A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation. in The Journal of biological chemistry 2002 (PubMed)
    Show all 5 references for ABIN967766

  3. Human Polyclonal PTPN6 Primary Antibody for IF, IHC (p) - ABIN319255 : Timms, Carlberg, Gu, Chen, Kamatkar, Nadler, Rohrschneider, Neel: Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages. in Molecular and cellular biology 1998 (PubMed)
    Show all 4 references for ABIN319255

  4. Human Polyclonal PTPN6 Primary Antibody for IF, IHC (p) - ABIN197592 : Kanagasundaram, Jaworowski, Byrne, Hamilton: Separation and characterization of the activated pool of colony-stimulating factor 1 receptor forming distinct multimeric complexes with signalling molecules in macrophages. in Molecular and cellular biology 1999 (PubMed)
    Show all 4 references for ABIN197592

  5. Human Polyclonal PTPN6 Primary Antibody for IF, IHC (p) - ABIN1882123 : Korporaal, Koekman, Verhoef, van der Wal, Bezemer, Van Eck, Akkerman: Downregulation of platelet responsiveness upon contact with LDL by the protein-tyrosine phosphatases SHP-1 and SHP-2. in Arteriosclerosis, thrombosis, and vascular biology 2009 (PubMed)
    Show all 2 references for ABIN1882123

  6. Human Polyclonal PTPN6 Primary Antibody for EIA, WB - ABIN374793 : Dubois, Bergeron, Kim, Dombrowski, Perreault, Fournès, Faure, Olivier, Beauchemin, Shulman, Siminovitch, Kim, Marette: The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis. in Nature medicine 2006 (PubMed)

More Antibodies against PTPN6 Interaction Partners

Mouse (Murine) Protein-tyrosine Phosphatase 1C (PTPN6) interaction partners

  1. Our data show that SHP1 is required for the survival of mature thymocytes and the generation of the functional T-cell repertoire, as its absence leads to a reduction in the numbers of CD4 (show CD4 Antibodies)(+) and CD8 (show CD8A Antibodies)(+) naive T cells in the peripheral lymphoid compartments.

  2. Our study suggests that metformin exerts its insulin sensitizing effects via inhibition of SHP-1 activity and expression.

  3. we found that THEMIS directly regulated the catalytic activity of the tyrosine phosphatase SHP-1.

  4. Mortality of SHP (show LAMC1 Antibodies)-/- mice after ethanol binge feeding was significantly reduced and Aldh2 (show ALDH2 Antibodies) mRNA level was higher. After an intoxicating dose of ethanol, SHP (show LAMC1 Antibodies)-/- mice exhibited faster blood ethanol clearance.

  5. Studies indicate that SHP1 and SYK (show SYK Antibodies) crosstalk as a critical regulator of MyD88 (show MYD88 Antibodies) post-translational modifications and IL-1 (show IL1A Antibodies)-driven inflammation.

  6. Our findings uncover an important role for PP6 as an indispensable guardian of genomic integrity of the lengthy prophase I oocyte arrest, maintenance of primordial follicle pool, and thus female fertility.

  7. The goal of this study was to analyze differentially expressed genes in the bone marrow of mice with NDLD to gain insight into the role of Ptpn6 in myelopoietic bone marrow pathology, and the mechanisms by which Ptpn6 insufficiency in the hematopoietic cells can lead to the development of skin lesions.

  8. the reduction in the positive selection conferred by CD5 overexpression was unaffected by SHP-1 deficiency.

  9. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  10. This study reveals SHP (show LAMC1 Antibodies) as a global transcriptional partner of SREBP-2 (show SREBF2 Antibodies) in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19 (show FGF19 Antibodies).

Human Protein-tyrosine Phosphatase 1C (PTPN6) interaction partners

  1. we found that THEMIS directly regulated the catalytic activity of the tyrosine phosphatase SHP-1.

  2. Hyperglycemia induces SHP-1 promoter epigenetic modifications, causing its persistent expression and activity and leading to insulin (show INS Antibodies) resistance, podocyte dysfunction, and DN.

  3. Low SHP1 expression is associated with primary central nervous system lymphoma.

  4. study evaluated SHP1-P2 methylation levels in the lymph nodes of colorectal cancer (CRC) patients; hypothesized that SHP1-P2 methylation levels would be higher in metastatic lymph nodes

  5. Overexpression of SHP1 downregulates the JAK2 (show JAK2 Antibodies)/STAT3 (show STAT3 Antibodies) pathway to modulate various target genes and inhibit cell proliferation, migration, and invasion in gastric cancer cells.

  6. This study also found no correlation of SHP-1 expression at diagnosis with response to treatment, although a trend for lower SHP-1 expression was noted in the very small non-responders' group of the 3-month therapeutic milestone.

  7. SYK (show SYK Antibodies), LYN (show LYN Antibodies) and PTPN6 were markedly elevated in atherosclerotic plaques of carotid atherosclerosis patients.

  8. cAMP signalling of Bordetella adenylate cyclase toxin through the SHP-1 phosphatase activates the BimEL (show BCL2L11 Antibodies)-Bax (show BAX Antibodies) pro-apoptotic cascade in phagocytes.

  9. Quinalizarin enhances radiosensitivity of nasopharyngeal carcinoma cells partially by suppressing SHP-1 expression

  10. N225K and A550V PTPN6 mutations cause loss-of-function leading to JAK3 (show JAK3 Antibodies) mediated deregulation of STAT3 (show STAT3 Antibodies) pathway and uncover a mechanism that tumor cells can use to control PTPN6 substrate specificity.

PTPN6 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

Alternative names and synonyms associated with PTPN6

  • protein tyrosine phosphatase, non-receptor type 6 (PTPN6) antibody
  • nuclear receptor subfamily 0, group B, member 2 (Nr0b2) antibody
  • protein tyrosine phosphatase, non-receptor type 6 (Ptpn6) antibody
  • DRPLA antibody
  • hcp antibody
  • Hcph antibody
  • HPTP1C antibody
  • me antibody
  • motheaten antibody
  • PTP-1C antibody
  • Ptp1C antibody
  • Ptph6 antibody
  • SH-PTP1 antibody
  • SHP antibody
  • Shp-1 antibody
  • SHP-1L antibody
  • SHP1 antibody

Protein level used designations for PTPN6

nuclear receptor subfamily 0 group B member 2 , orphan nuclear receptor SHP , small heterodimer partner , hematopoietic cell phosphatase , hematopoietic cell protein-tyrosine phosphatase , protein-tyrosine phosphatase 1C , protein-tyrosine phosphatase SHP-1 , tyrosine-protein phosphatase non-receptor type 6 , 70Z-SHP , PTP-1C , PTPTY-42 , SH-PTP1 , hemopoietic cell phosphatase , SH2 phosphatase 1 , dentatorubro-pallidoluysian atrophy protein , non-receptor type protein tyrosine phosphatase SHP1

GENE ID SPECIES
100052882 Equus caballus
23957 Mus musculus
5777 Homo sapiens
15170 Mus musculus
116689 Rattus norvegicus
486717 Canis lupus familiaris
100171389 Sus scrofa
100723417 Cavia porcellus
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