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anti-Human PTPN6 antibody for Enzyme Immunoassay

Recommended PTPN6 Antibody (supplied by: Log in to see )

Antigen
Protein-tyrosine Phosphatase 1C (PTPN6) Antibodies
  • SHP
  • SHP-1
  • Shp1
  • HCP
  • HCPH
  • HPTP1C
  • PTP-1C
  • SH-PTP1
  • SHP-1L
  • SHP1
  • Hcph
  • Ptp1C
  • hcp
  • me
  • motheaten
  • Ptph6
  • Shp-1
  • DRPLA
  • protein tyrosine phosphatase, non-receptor type 6
  • nuclear receptor subfamily 0, group B, member 2
  • PTPN6
  • Nr0b2
  • Ptpn6
Epitope
C-Term, Internal Region
27
24
15
9
7
5
4
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
189
94
89
8
3
3
3
2
1
1
1
1
Host
Goat
122
34
33
Clonality
Polyclonal
Conjugate
This PTPN6 antibody is un-conjugated
7
7
7
3
3
2
2
2
2
2
2
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
138
78
58
30
29
29
9
8
5
5
4
1
1
Supplier
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Catalog No. ABIN374793
$ 379.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN954377 EIA IHC (p) WB Mouse IgG1 Log in to see 14D5
1 ABIN114550 EIA IHC (fro) IF WB Mouse IgG1 Log in to see PTY6
1 ABIN114551 EIA IHC (fro) IF WB Mouse IgG2a Log in to see PTY10
1 ABIN452174 EIA IHC (fro) IF WB Mouse IgG1 Log in to see PTY11
1 ABIN452175 EIA IHC (fro) IF WB Mouse IgG1 Log in to see PTY15

Top referenced anti-PTPN6 antibody for Enzyme Immunoassay

Similar anti-PTPN6 Antibodies

Application / Reactivity Human
ELISA 78 Antibodies
Enzyme Immunoassay (EIA) 6 Antibodies
Flow Cytometry (FACS) 1 Antibodies
Immunochromatography (IC) 1 Antibodies
Immunocytochemistry (ICC) 8 Antibodies
Immunofluorescence (IF) 29 Antibodies
Immunofluorescence (fixed cells) (IF/ICC) 4 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 29 Antibodies
Immunohistochemistry (IHC) 58 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 5 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 30 Antibodies
Immunoprecipitation (IP) 9 Antibodies
Western Blotting (WB) 139 Antibodies

General

Antigen Protein-tyrosine Phosphatase 1C (PTPN6) Antibodies
Epitope C-Term, Internal Region
(27), (24), (15), (9), (7), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(189), (94), (89), (8), (3), (3), (3), (2), (1), (1), (1), (1)
Host Goat
(122), (34), (33)
Clonality
Polyclonal
Conjugate This PTPN6 antibody is un-conjugated
(7), (7), (7), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Enzyme Immunoassay (EIA), Western Blotting (WB)
(138), (78), (58), (30), (29), (29), (9), (8), (5), (5), (4), (1), (1)
Pubmed 1 reference available
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Product Details anti-PTPN6 Antibody

Target Details PTPN6 Application Details Handling References for anti-PTPN6 Antibody (ABIN374793) Images
Sequence C-HTKNKREEKV KKQ
Specificity This antibody is expected to recognise both reported isoforms of Human PTPN6 (NP_536858.1 and NP_002822.2).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Immunogen Peptide from the internal region (near the C Terminus) of the protein sequence according to NP_536858.1 and NP_002822.2. Genename: PTPN6

Target Details PTPN6

Product Details anti-PTPN6 Antibody Application Details Handling References for anti-PTPN6 Antibody (ABIN374793) Images back to top
Antigen
Alternative Name PTPN6 (PTPN6 Antibody Abstract)
Background SHP1 is a member of the non receptor protein tyrosine phosphatase subfamily. The PTP family comprises of at least 37 proteins, characterized by a catalytic phosphatase domain of approximately 240 amino acids, and includes both transmembrane and cytosolic enzymes. PTP1B is cytosolic. The PTPs have high substrate specificity for phosphotyrosyl proteins, at the primary sequence level sharing little similarity with the protein serine phosphatases, protein threonine phosphatases, or the acid and alkaline phosphatases. SHP1 is implicated in the control of tyrosine kinase signalling pathways in cellular proliferation, with a potential role in cancer.Synonyms: HCP, Hematopoietic cell protein-tyrosine phosphatase, PTP-1C, PTP1C, PTPN-6, Protein-tyrosine phosphatase 1C, Protein-tyrosine phosphatase SHP-1, SH-PTP1, Tyrosine-protein phosphatase non-receptor type 6
Gene ID 5777
NCBI Accession NP_002822
UniProt P29350
Pathways JAK-STAT Signaling, TLR Signaling, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity

Application Details

Product Details anti-PTPN6 Antibody Target Details PTPN6 Handling References for anti-PTPN6 Antibody (ABIN374793) Images back to top
Application Notes Peptide ELISA: antibody detection limit dilution 1: 128000. Western blot: 0.2-0.5 μg/mL. Approx 70 kDa band observed in lysates of cell lines Jurkat andU937 (calculated MW of 67.0 kDa according to NP_536858.1 and 67.0 kDa according toNP_002822.2).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-PTPN6 Antibody Target Details PTPN6 Application Details References for anti-PTPN6 Antibody (ABIN374793) Images back to top
Concentration 0.5 mg/mL
Buffer Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-PTPN6 Antibody (ABIN374793)

Product Details anti-PTPN6 Antibody Target Details PTPN6 Application Details Handling Images back to top
Background publications

Dubois, Bergeron, Kim, Dombrowski, Perreault, Fournès, Faure, Olivier, Beauchemin, Shulman, Siminovitch, Kim, Marette: "The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis." in: Nature medicine, Vol. 12, Issue 5, pp. 549-56, 2006

Images

Product Details anti-PTPN6 Antibody Target Details PTPN6 Application Details Handling References for anti-PTPN6 Antibody (ABIN374793) back to top
Supplier Images
 image for anti-PTPN6 antibody (Protein-tyrosine Phosphatase 1C) (C-Term) (ABIN374793) anti-Protein-tyrosine Phosphatase 1C (PTPN6) (C-Term), (Internal Region) antibody