anti-Human PTPN6 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended PTPN6 Antibody (supplied by: Log in to see )

Antigen
Protein-tyrosine Phosphatase 1C (PTPN6) Antibodies
  • SHP
  • SHP-1
  • Shp1
  • HCP
  • HCPH
  • HPTP1C
  • PTP-1C
  • SH-PTP1
  • SHP-1L
  • SHP1
  • Hcph
  • Ptp1C
  • hcp
  • me
  • motheaten
  • Ptph6
  • Shp-1
  • DRPLA
  • protein tyrosine phosphatase, non-receptor type 6
  • nuclear receptor subfamily 0, group B, member 2
  • PTPN6
  • Nr0b2
  • Ptpn6
Epitope
pTyr536
34
26
15
10
8
6
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human
215
89
84
7
3
2
2
2
1
1
1
1
1
Host
Rabbit
143
40
33
Clonality
Polyclonal
Conjugate
This PTPN6 antibody is conjugated to Alexa Fluor 647
9
9
8
3
3
3
3
3
3
3
3
3
3
3
3
2
2
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
151
84
57
38
37
34
17
10
8
6
5
4
2
1
Options
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Catalog No. ABIN879862
$ 427.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN711626 IF (p) IHC (p) WB Rabbit IgG pTyr536 Log in to see Polyclonal
1 ABIN711641 IF (p) IHC (p) WB Rabbit IgG pSer591 Log in to see Polyclonal
1 ABIN876615 IF (p) Alexa Fluor 647 Rabbit IgG pSer591 Log in to see Polyclonal
1 ABIN876614 IF (p) Alexa Fluor 488 Rabbit IgG pSer591 Log in to see Polyclonal
1 ABIN876616 IF (p) Alexa Fluor 555 Rabbit IgG pSer591 Log in to see Polyclonal
1 ABIN876613 IF (p) Alexa Fluor 350 Rabbit IgG pSer591 Log in to see Polyclonal
1 ABIN879863 IF (p) Alexa Fluor 350 Rabbit IgG pTyr536 Log in to see Polyclonal
1 ABIN879864 IF (p) Alexa Fluor 555 Rabbit IgG pTyr536 Log in to see Polyclonal
1 ABIN879861 IF (p) Alexa Fluor 488 Rabbit IgG pTyr536 Log in to see Polyclonal
1 ABIN711629 IF (p) Cy3 Rabbit IgG pTyr536 Log in to see Polyclonal
1 ABIN711630 IF (p) Cy5 Rabbit IgG pTyr536 Log in to see Polyclonal
1 ABIN711632 IF (p) Cy7 Rabbit IgG pTyr536 Log in to see Polyclonal
1 ABIN711644 IF (p) Cy3 Rabbit IgG pSer591 Log in to see Polyclonal
1 ABIN711633 IF (p) FITC Rabbit IgG pTyr536 Log in to see Polyclonal
1 ABIN711645 IF (p) Cy5 Rabbit IgG pSer591 Log in to see Polyclonal
1 ABIN711631 IF (p) Cy5.5 Rabbit IgG pTyr536 Log in to see Polyclonal
1 ABIN711647 IF (p) Cy7 Rabbit IgG pSer591 Log in to see Polyclonal
1 ABIN711648 IF (p) FITC Rabbit IgG pSer591 Log in to see Polyclonal
1 ABIN711646 IF (p) Cy5.5 Rabbit IgG pSer591 Log in to see Polyclonal
1 ABIN2805697 IF (p) Alexa Fluor 594 Rabbit IgG pSer591 Log in to see Polyclonal

General

Antigen Protein-tyrosine Phosphatase 1C (PTPN6) Antibodies
Epitope pTyr536
(34), (26), (15), (10), (8), (6), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(215), (89), (84), (7), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Host Rabbit
(143), (40), (33)
Clonality
Polyclonal
Conjugate This PTPN6 antibody is conjugated to Alexa Fluor 647
(9), (9), (8), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p))
(151), (84), (57), (38), (37), (34), (17), (10), (8), (6), (5), (4), (2), (1)
Pubmed 1 reference available
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Product Details anti-PTPN6 Antibody

Target Details PTPN6 Application Details Handling References for anti-PTPN6 antibody (ABIN879862) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human PTPN6 around the phosphorylation site of Tyr536 [SE(p-Y)GN]
Isotype IgG

Target Details PTPN6

Product Details anti-PTPN6 Antibody Application Details Handling References for anti-PTPN6 antibody (ABIN879862) Images back to top
Antigen
Alternative Name Ptpn6 (PTPN6 Antibody Abstract)
Background

SHP1 is a member of the non receptor protein tyrosine phosphatase subfamily. The PTP family comprises of at least 37 proteins, characterized by a catalytic phosphatase domain of approximately 240 amino acids, and includes both transmembrane and cytosolic enzymes. PTP1B is cytosolic. The PTPs have high substrate specificity for phosphotyrosyl proteins, at the primary sequence level sharing little similarity with the protein serine phosphatases, protein threonine phosphatases, or the acid and alkaline phosphatases. SHP1 is implicated in the control of tyrosine kinase signalling pathways in cellular proliferation, with a potential role in cancer.

Subcellular location: Cytoplasm, Nucleus

Synonyms: SHP-1Tyr536, PTPN6phospho Y536, SHP1phospho Y536, 70 kda SHP1L protein, HCP, HCPH, Hematopoietic cell phosphatase, Hematopoietic cell protein tyrosine phosphatase, Hematopoietic cell protein-tyrosine phosphatase, HPTP1C, Protein tyrosine phosphatase 1C, Protein tyrosine phosphatase non receptor type 6, Protein tyrosine phosphatase SHP1, PTP1C, PTPN6, SH PTP 1, SHP1, SHP1L, PTN6_HUMAN.

Gene ID 5777
Pathways JAK-STAT Signaling, TCR Signaling, TLR Signaling, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2

Application Details

Product Details anti-PTPN6 Antibody Target Details PTPN6 Handling References for anti-PTPN6 antibody (ABIN879862) Images back to top
Application Notes IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-PTPN6 Antibody Target Details PTPN6 Application Details References for anti-PTPN6 antibody (ABIN879862) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C
Expiry Date 12 months

References for anti-PTPN6 antibody (ABIN879862)

Product Details anti-PTPN6 Antibody Target Details PTPN6 Application Details Handling Images back to top
Product cited in:

Lopes, Bálint, Valvo, Felce, Hessel, Dustin, Davis: "Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages." in: The Journal of cell biology, Vol. 216, Issue 4, pp. 1123-1141, 2017 Method employed by authors: Immunofluorescence (fixed cells) (IF/ICC) (Sample species: Human).