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|Antigen||Protein-tyrosine Phosphatase 1C (PTPN6) Antibodies|
|Conjugate||This PTPN6 antibody is conjugated to Alexa Fluor 647 Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
|1 reference available|
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Product Details anti-PTPN6 AntibodyTarget Details PTPN6 Application Details Handling References for anti-PTPN6 antibody (ABIN879862) Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic phosphopeptide derived from human PTPN6 around the phosphorylation site of Tyr536 [SE(p-Y)GN]|
Target Details PTPN6Product Details anti-PTPN6 Antibody Application Details Handling References for anti-PTPN6 antibody (ABIN879862) Images back to top
|Alternative Name||Ptpn6 (PTPN6 Antibody Abstract)|
SHP1 is a member of the non receptor protein tyrosine phosphatase subfamily. The PTP family comprises of at least 37 proteins, characterized by a catalytic phosphatase domain of approximately 240 amino acids, and includes both transmembrane and cytosolic enzymes. PTP1B is cytosolic. The PTPs have high substrate specificity for phosphotyrosyl proteins, at the primary sequence level sharing little similarity with the protein serine phosphatases, protein threonine phosphatases, or the acid and alkaline phosphatases. SHP1 is implicated in the control of tyrosine kinase signalling pathways in cellular proliferation, with a potential role in cancer.
Subcellular location: Cytoplasm, Nucleus
Synonyms: SHP-1Tyr536, PTPN6phospho Y536, SHP1phospho Y536, 70 kda SHP1L protein, HCP, HCPH, Hematopoietic cell phosphatase, Hematopoietic cell protein tyrosine phosphatase, Hematopoietic cell protein-tyrosine phosphatase, HPTP1C, Protein tyrosine phosphatase 1C, Protein tyrosine phosphatase non receptor type 6, Protein tyrosine phosphatase SHP1, PTP1C, PTPN6, SH PTP 1, SHP1, SHP1L, PTN6_HUMAN.
|Pathways||JAK-STAT Signaling, TCR Signaling, TLR Signaling, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2|
Application DetailsProduct Details anti-PTPN6 Antibody Target Details PTPN6 Handling References for anti-PTPN6 antibody (ABIN879862) Images back to top
|Application Notes||IF(IHC-P) 1:50-200|
|Restrictions||For Research Use only|
HandlingProduct Details anti-PTPN6 Antibody Target Details PTPN6 Application Details References for anti-PTPN6 antibody (ABIN879862) Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|
References for anti-PTPN6 antibody (ABIN879862)Product Details anti-PTPN6 Antibody Target Details PTPN6 Application Details Handling Images back to top
|Product cited in:||
Lopes, Bálint, Valvo, Felce, Hessel, Dustin, Davis: "Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages." in: The Journal of cell biology, Vol. 216, Issue 4, pp. 1123-1141, 2017 Method employed by authors: Immunofluorescence (fixed cells) (IF/ICC) (Sample species: Human).