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|Application / Reactivity||Human|
|Enzyme Immunoassay (EIA)||8 Antibodies|
|Flow Cytometry (FACS)||6 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||17 Antibodies|
|Immunofluorescence (IF)||36 Antibodies|
|Immunofluorescence (fixed cells) (IF/ICC)||4 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||29 Antibodies|
|Immunohistochemistry (IHC)||59 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||5 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||35 Antibodies|
|Immunoprecipitation (IP)||10 Antibodies|
|Radioimmunoassay (RIA)||2 Antibodies|
|Western Blotting (WB)||148 Antibodies|
|Antigen||Protein-tyrosine Phosphatase 1C (PTPN6) Antibodies|
|Conjugate||This PTPN6 antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-PTPN6 AntibodyTarget Details PTPN6 Application Details Handling ProductDetails: References for anti-PTPN6 antibody (ABIN264440) Images
|Specificity||Recognizes a protein of ~50 kDa, which is identified as the SH2-containing protein-tyrosine phosphatase 1 (SHP-1). This antibody is highly specific to SHP-1 and shows no cross-reaction with other protein-tyrosine phosphatase.|
|Characteristics||Synonyms: PTPN-6, HCP, PTP1C, EC=22.214.171.124, Protein-tyrosine phosphatase 1C, PTP-1C, SH-PTP1,Protein-tyrosine phosphatase SHP-1, Hematopoietic cell protein-tyrosine phosphatase,Tyrosine-protein phosphatase non-receptor type 6|
|Immunogen||Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized withrecombinant human SHP1 protein and mouse myeloma NS1 cells. Genename: PTPN6|
Target Details PTPN6Product Details anti-PTPN6 Antibody Application Details Handling ProductDetails: References for anti-PTPN6 antibody (ABIN264440) Images back to top
|Alternative Name||PTPN6 (PTPN6 Antibody Abstract)|
|Background||SHP-1 is known to play a crucial role in the regulation of hematopoiesis and it regulates the transcriptional activity stimulated by the erythropoietin (EPO)-induced JAK/STAT and MAPK pathways and is involved in the signaling machinery responsible for erythroid differentiation and suppression of apoptosis. Furthermore, the observation that SHP-1 associates with RAFTK/Pyk2/CAK activated by beta-chemokine receptor (CCR5) and SHP-1 also associates with the adaptor protein Grb2 and the Src-related kinase Syk indicates the role of SHP-1 in modulating cell migration, proliferation, and immune functions.Synonyms: HCP, Hematopoietic cell protein-tyrosine phosphatase, PTP-1C, PTP1C, PTPN-6, Protein-tyrosine phosphatase 1C, Protein-tyrosine phosphatase SHP-1, SH-PTP1, Tyrosine-protein phosphatase non-receptor type 6|
|Pathways||JAK-STAT Signaling, TCR Signaling, TLR Signaling, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2|
Application DetailsProduct Details anti-PTPN6 Antibody Target Details PTPN6 Handling ProductDetails: References for anti-PTPN6 antibody (ABIN264440) Images back to top
Western Blot (1 μg/mL). Immunoprecipitation (2 g/mg of protein lysate). Positive Control: HeLa cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-PTPN6 Antibody Target Details PTPN6 Application Details ProductDetails: References for anti-PTPN6 antibody (ABIN264440) Images back to top
|Buffer||PBS containing 0.08 % Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
|Expiry Date||12 months|
ProductDetails: References for anti-PTPN6 antibody (ABIN264440)Product Details anti-PTPN6 Antibody Target Details PTPN6 Application Details Handling Images back to top
Bittorf, Seiler, Zhang, Jaster, Brock: "SHP1 protein tyrosine phosphatase negatively modulates erythroid differentiation and suppression of apoptosis in J2E erythroleukemic cells." in: Biological chemistry, Vol. 380, Issue 10, pp. 1201-9, 2000
Ganju, Brubaker, Chernock, Avraham, Groopman: "Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk." in: The Journal of biological chemistry, Vol. 275, Issue 23, pp. 17263-8, 2000
Xie, Zhang, Siraganian: "Positive regulation of c-Jun N-terminal kinase and TNF-alpha production but not histamine release by SHP-1 in RBL-2H3 mast cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 3, pp. 1521-8, 2000
Daws, Eriksson, Oberg, Ullén, Sentman: "H-2Dd engagement of Ly49A leads directly to Ly49A phosphorylation and recruitment of SHP1." in: Immunology, Vol. 97, Issue 4, pp. 656-64, 1999
Bone, Dechert, Jirik, Schrader, Welham: "SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substrates." in: The Journal of biological chemistry, Vol. 272, Issue 22, pp. 14470-6, 1997