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anti-Human PTPN6 antibody for Immunoprecipitation

Recommended PTPN6 Antibody (supplied by: Log in to see )

Antigen
Protein-tyrosine Phosphatase 1C (PTPN6) Antibodies
  • SHP
  • SHP-1
  • Shp1
  • HCP
  • HCPH
  • HPTP1C
  • PTP-1C
  • SH-PTP1
  • SHP-1L
  • SHP1
  • Hcph
  • Ptp1C
  • hcp
  • me
  • motheaten
  • Ptph6
  • Shp-1
  • DRPLA
  • protein tyrosine phosphatase, non-receptor type 6
  • nuclear receptor subfamily 0, group B, member 2
  • PTPN6
  • Nr0b2
  • Ptpn6
Reactivity
Human
187
91
86
7
3
2
2
2
1
1
1
1
1
Host
Mouse
122
33
33
Clonality
Monoclonal
Conjugate
This PTPN6 antibody is un-conjugated
7
7
7
3
3
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
138
78
56
30
29
29
9
9
6
5
4
2
1
Supplier
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Catalog No. ABIN264440
$ 654.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN967767 IF IP IHC WB Mouse IgG1 AA 492-597 Log in to see 52-PTP1C-SHP1 5
1 ABIN967766 IF IP IHC WB Mouse IgG1 AA 492-597 Log in to see 52-PTP1C-SHP1 5
1 ABIN442153 IHC IHC (p) IP WB Rabbit IgG Center Log in to see Polyclonal
1 ABIN4348609 IP WB Rabbit Log in to see NL213
1 ABIN114552 IHC (fro) IP WB Mouse IgG2a Log in to see PTY13
1 ABIN1585210 IP IHC ELISA WB Rabbit N-Term Log in to see Polyclonal
1 ABIN1870125 ICC IHC IP WB Rabbit IgG AA 244-515 Log in to see Polyclonal
1 ABIN201666 IP WB Mouse IgG2b Log in to see

Top referenced anti-PTPN6 antibody for Immunoprecipitation

Similar anti-PTPN6 Antibodies

Application / Reactivity Human
ELISA 77 Antibodies
Enzyme Immunoassay (EIA) 6 Antibodies
Flow Cytometry (FACS) 2 Antibodies
Immunochromatography (IC) 1 Antibodies
Immunocytochemistry (ICC) 9 Antibodies
Immunofluorescence (IF) 29 Antibodies
Immunofluorescence (fixed cells) (IF/ICC) 4 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 29 Antibodies
Immunohistochemistry (IHC) 56 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 5 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 31 Antibodies
Immunoprecipitation (IP) 9 Antibodies
Western Blotting (WB) 138 Antibodies

General

Antigen Protein-tyrosine Phosphatase 1C (PTPN6) Antibodies
Reactivity Human
(187), (91), (86), (7), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Host Mouse
(122), (33), (33)
Clonality (Clone)
Monoclonal   ( )
Conjugate This PTPN6 antibody is un-conjugated
(7), (7), (7), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
(138), (78), (56), (30), (29), (29), (9), (9), (6), (5), (4), (2), (1)
Pubmed 5 references available
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Product Details anti-PTPN6 Antibody

Target Details PTPN6 Application Details Handling References for anti-PTPN6 Antibody (ABIN264440) Images
Specificity Recognizes a protein of ~50 kDa, which is identified as the SH2-containing protein-tyrosine phosphatase 1 (SHP-1). This antibody is highly specific to SHP-1 and shows no cross-reaction with other protein-tyrosine phosphatase.
Characteristics Synonyms: PTPN-6, HCP, PTP1C, EC=3.1.3.48, Protein-tyrosine phosphatase 1C, PTP-1C, SH-PTP1,Protein-tyrosine phosphatase SHP-1, Hematopoietic cell protein-tyrosine phosphatase,Tyrosine-protein phosphatase non-receptor type 6
Purification Purified
Immunogen Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized withrecombinant human SHP1 protein and mouse myeloma NS1 cells. Genename: PTPN6
Clone 1SH01
Isotype IgG2b

Target Details PTPN6

Product Details anti-PTPN6 Antibody Application Details Handling References for anti-PTPN6 Antibody (ABIN264440) Images back to top
Antigen
Alternative Name PTPN6 (PTPN6 Antibody Abstract)
Background SHP-1 is known to play a crucial role in the regulation of hematopoiesis and it regulates the transcriptional activity stimulated by the erythropoietin (EPO)-induced JAK/STAT and MAPK pathways and is involved in the signaling machinery responsible for erythroid differentiation and suppression of apoptosis. Furthermore, the observation that SHP-1 associates with RAFTK/Pyk2/CAK activated by beta-chemokine receptor (CCR5) and SHP-1 also associates with the adaptor protein Grb2 and the Src-related kinase Syk indicates the role of SHP-1 in modulating cell migration, proliferation, and immune functions.Synonyms: HCP, Hematopoietic cell protein-tyrosine phosphatase, PTP-1C, PTP1C, PTPN-6, Protein-tyrosine phosphatase 1C, Protein-tyrosine phosphatase SHP-1, SH-PTP1, Tyrosine-protein phosphatase non-receptor type 6
Gene ID 5777
UniProt P29350
Pathways JAK-STAT Signaling, TLR Signaling, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2

Application Details

Product Details anti-PTPN6 Antibody Target Details PTPN6 Handling References for anti-PTPN6 Antibody (ABIN264440) Images back to top
Application Notes Western Blot (1 μg/mL). Immunoprecipitation (2 g/mg of protein lysate). Positive Control: HeLa cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-PTPN6 Antibody Target Details PTPN6 Application Details References for anti-PTPN6 Antibody (ABIN264440) Images back to top
Buffer PBS containing 0.08 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Expiry Date 12 months

References for anti-PTPN6 Antibody (ABIN264440)

Product Details anti-PTPN6 Antibody Target Details PTPN6 Application Details Handling Images back to top
Background publications

Bittorf, Seiler, Zhang, Jaster, Brock: "SHP1 protein tyrosine phosphatase negatively modulates erythroid differentiation and suppression of apoptosis in J2E erythroleukemic cells." in: Biological chemistry, Vol. 380, Issue 10, pp. 1201-9, 2000

Ganju, Brubaker, Chernock, Avraham, Groopman: "Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk." in: The Journal of biological chemistry, Vol. 275, Issue 23, pp. 17263-8, 2000

Xie, Zhang, Siraganian: "Positive regulation of c-Jun N-terminal kinase and TNF-alpha production but not histamine release by SHP-1 in RBL-2H3 mast cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 3, pp. 1521-8, 2000

Daws, Eriksson, Oberg, Ullén, Sentman: "H-2Dd engagement of Ly49A leads directly to Ly49A phosphorylation and recruitment of SHP1." in: Immunology, Vol. 97, Issue 4, pp. 656-64, 1999

Bone, Dechert, Jirik, Schrader, Welham: "SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substrates." in: The Journal of biological chemistry, Vol. 272, Issue 22, pp. 14470-6, 1997