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Activation of 5-HT1A and OAMB signaling in Insulin-producing cells generates differential effects on Dilp transcription, fly physiology, metabolism and social interactions.
serotonin acts on brain IPCs via the 5-HT(1A) receptor, thereby affecting their activity and probably insulin (show INS ELISA Kits) signaling
Decrease in 5-HT(1A) receptor binding partly reflects hippocampal neuronal loss in temporal lobe epilepsy.
The Drosophila serotonin receptor 1A has a role in promoting baseline sleep.
study describes the influence of different 5-HT receptor subtypes on aggressive behaviors; activation of 5-HT(1A)-like receptors with 8-OH-DPAT increases overall aggression; 5-HT(1A)-like receptor manipulation primarily affects wing threats and fencing
5-HT(2) receptors are coupled to phospholipase C (show PLC ELISA Kits) in bovine ciliary epithelium.
the 5-HT(1A) receptor contains high and moderate affinity CaM binding regions that may play important roles in receptor signaling and function
analysis of eight bovine 5-HT receptor subtypes in brain, abomasum, and intestine by real-time RT-PCR
role of cholesterol in solubilization of G-protein-coupled serotonin 1A receptors
ligand binding function of the 5-HT(1A) receptor is a cholesterol-dependent phenomenon that is not related to the ability of cholesterol to modulate membrane order
Increased levels of 5-HT1A receptor binding were seen in the raphe nuclei following chronic ethanol self-administration.
Cimbi-36 is the first agonist radioligand suitable for examination of 5-HT2A receptors in the cortical regions and of 5-HT2C receptors in the choroid plexus of the primate brain.
Significantly lower 5-HT1A binding is found in s-carrier subjects (5-HTTLPR (show SLC6A4 ELISA Kits) genotype) in both cortical brain regions and the raphe nuclei.
5-HT1A receptor levels increase during development in the female brain from pre-to peripuberty.
5HT1A receptor may lose sensitivity to the suppressive effect of estradiol after 5 months, whereas the 5HT2C receptor increases, however, addition of progesterone in the EP5 regimen maintains the regulatory effects
5-HT(1A), SST (show SST ELISA Kits)(1), and SST (show SST ELISA Kits)(2) receptors mediate nonadrenergic IPSPs in the noncholinergic (VIP (show Vip ELISA Kits)) secretomotor neurons of the submucous plexus of the guinea pig ileum.
Since the 5-HT(1A) and 5-HT(2) agonists decreased and increased, respectively, the duration of TI, different serotonin receptor (show HTR1B ELISA Kits) subtypes may play distinct roles in the modulation of TI in the guinea pig.
The sex dependence of Deaf1 (show DEAF1 ELISA Kits) function in mice is consistent with a greater role for 5-HT1A autoreceptors in sensitivity to depression in men.
we showed that gravity changes induced differential modulation of gene expression of BDNF (show BDNF ELISA Kits) and 5-HTRs (5-HT1AR, 5-HT1BR and 5-HT2AR) in some brain regions. The modulation of gene expression may constitute molecular bases that underlie behavioral alteration induced by gravity changes.
Results suggest that 5HT (show DDC ELISA Kits) acting at 5HT1aR in the Kolliker-Fuse nucleus may modulate both the intrinsic and extrinsic sources of respiratory rhythm variability.
Among patients with major depressive disorder, it was found that patients with the C/C genotype for the C(1019)G polymorphism of the 5-HT1A-R were significantly superior in retaining and retrieving information, in both working and episodic memory, than those with either the C/G or the G/G genotypes.
Data show that the fine control of excitatory transmission by glycogen synthase kinase 3 (show GSK3a ELISA Kits) requires recruitment of dopamine D2-receptors and depends on the presence of serotonin 5-HT1A-receptors.
the activation of TLR3 (show TLR3 ELISA Kits) promotes the loss of RGCs and their axons by elevating Rtca (show RTCD1 ELISA Kits) levels in the retina. Also, the results presented in this study show that Rtca (show RTCD1 ELISA Kits) regulates JNK3 (show MAPK10 ELISA Kits) expression in the retina.
Findings indicate that cannabidiol could represent a novel fast antidepressant drug, via enhancing both serotonergic and glutamate (show GRIN1 ELISA Kits) cortical signalling through a 5-HT1A receptor (show CC2D1A ELISA Kits)-dependent mechanism.
The results of this study suggested that the hallucinogen action of 5-MeO-DMT is mediated by simultaneous alterations of the activity of cerebral cortex also supporting a role of 5-HT(1A)-R stimulation in V1 and PFC (show CFP ELISA Kits).
Results indicate that GIRK channels formed by GIRK2 (show KCNJ6 ELISA Kits) subunits determine depression-related behaviors as well as basal and 5-HT1A receptor (show CC2D1A ELISA Kits)-mediated dorsal raphe neuronal activity
Results indicate that postsynaptic 5-HT1A receptors exert a modulatory function in food intake in free-feeding and fasted mice, which for the first time shows an involvement of postsynaptic 5-HT1A receptors in feeding behavior
This study demonstrated that a significant decrease in the protein level of 5-HT1A in major depression disorder.
5-HT1A rs10042486 was significantly associated with schizophrenia
Results reveal the broad dependence that the 5-HT1A receptor has on plasma membrane properties, demonstrating that membrane lipid composition is a biochemical control parameter and highlighting the possibility that compositional changes related to aging, diet, or disease could impact cell signaling functions
The ganglioside GM1 interacts with the serotonin1A receptor via the sphingolipid binding domain.
5-HT1A C-1019G (rs6295) can predict aripiprazole treatment response specifically for cognitive and depressive symptoms in schizophrenia.
results show that the oxidation of the hydroxyl group of cholesterol in live cells resulted in enhancement of agonist binding and G-protein coupling to the serotonin1A receptor with no appreciable change in overall membrane order; results extend our understanding of the structural requirements of cholesterol for receptor function
A single-nucleotide polymorphism of the serotonin 1a receptor gene (HTR1A) has been designated rs6295.28 and found to be overrepresented in suicide and associated with a decreased responsiveness to antidepressants.
Results reported here strongly support the role of 5-HT1A partial agonism as a means of restoring cognitive function following subchronic treatment with an NMDAR (show GRIN1 ELISA Kits) non-competitiave antagonist
This study demonistrated that cue learning, trait anxiety and genetic variability in 5-HTR1A are involved in the regulation of contextual anxiety.
epistatic effects of 5HTR1A and 5HTR2A genes on suicidal behaviour were not significant
Polymorphism in the serotonin receptor 1A gene may affect tractability in horses, with the effect partially different depending on sex.
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers.
, serotonin receptor 1A
, serotonin receptor 2A
, 5-hydroxytryptamine receptor 1A
, 5-hydroxytryptamine (serotonin) receptor 1A
, 5-HT1A receptor
, G-protein coupled receptor 18
, 5-HT1a receptor
, guanine nucleotide-binding regulatory protein-coupled receptor
, Serotonin receptor 1A