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|Application / Reactivity||Rat (Rattus)||Mouse (Murine)||Human|
|ELISA||9 Antibodies||5 Antibodies||31 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies||1 Antibodies||2 Antibodies|
|Immunocytochemistry (ICC)||3 Antibodies||2 Antibodies||3 Antibodies|
|Immunofluorescence (IF)||11 Antibodies||6 Antibodies||17 Antibodies|
|Immunohistochemistry (IHC)||2 Antibodies||4 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||4 Antibodies||4 Antibodies|
|Western Blotting (WB)||17 Antibodies||15 Antibodies|
|Antigen||Serotonin Receptor 4 (HTR4) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This Serotonin Receptor 4 antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-Serotonin Receptor 4 AntibodyTarget Details Serotonin Receptor 4 Application Details Handling Images
|Specificity||This antibody detects endogenous levels of SR-4 protein. (region surrounding Asp47)|
Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
|Purification||Affinity Chromatography using epitope-specific immunogen|
Target Details Serotonin Receptor 4Product Details anti-Serotonin Receptor 4 Antibody Application Details Handling Images back to top
|Alternative Name||Serotonin Receptor 4 / HTR4 (HTR4 Antibody Abstract)|
|Background||Serotonin (also designated 5-hydroxytryptamine or 5-HT) is a molecule that functions as a neurotransmitter, a hormone and a mitogen, and it is predominantly expressed in the gut, platelets and central nervous system (CNS). In the CNS, serotonin modulates several processes, including anxiety, sleep, appetite, behavior and drug abuse. In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5-HT receptors or alternatively SR receptors. SR-3 is a ligand-gated ion channel, whereas all other known serotonin receptor subtypes are G protein-coupled receptors. The gene which encodes SR-3 maps to human chromosome 11q23.1-q23.2. SR-4 mediates widespread effects in central and peripheral nervous systems. The gene which encodes SR-4 maps to human chromosome 5q31-q33. SR-7 belongs to the superfamily of G protein-coupled receptors. The gene which encodes SR-7 maps to human chromosome 10q21-q24.Synonyms: 5-HT-4, 5-HT4, 5-hydroxytryptamine receptor 4|
|Molecular Weight||approx. 48 kDa|
Application DetailsProduct Details anti-Serotonin Receptor 4 Antibody Target Details Serotonin Receptor 4 Handling Images back to top
Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Serotonin Receptor 4 Antibody Target Details Serotonin Receptor 4 Application Details Images back to top
|Buffer||Phosphate buffered saline (PBS), pH 7.2., 15 mM Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
ImagesProduct Details anti-Serotonin Receptor 4 Antibody Target Details Serotonin Receptor 4 Application Details Handling back to top