Browse our anti-SOCS1 (SOCS1) Antibodies

Full name:
anti-Suppressor of Cytokine Signaling 1 Antibodies (SOCS1)
On www.antibodies-online.com are 176 Suppressor of Cytokine Signaling 1 (SOCS1) Antibodies from 29 different suppliers available. Additionally we are shipping SOCS1 Kits (25) and SOCS1 Proteins (13) and many more products for this protein. A total of 228 SOCS1 products are currently listed.
Synonyms:
CIS1, Cish1, Cish7, JAB, LOC100228306, Socs-1, SOCS1, socs1b, SSI-1, SSI1, TIP3, zgc:91868
list all antibodies Gene Name GeneID UniProt
SOCS1 8651 O15524
SOCS1 12703 O35716
SOCS1 252971 Q9QX78

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Top referenced anti-SOCS1 Antibodies

  1. Human Polyclonal SOCS1 Primary Antibody for WB - ABIN252586 : Prêle, Woodward, Bisley, Keith-Magee, Nicholson, Hart: SOCS1 regulates the IFN but not NFkappaB pathway in TLR-stimulated human monocytes and macrophages. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)
    Show all 4 references for 252586

  2. Human Polyclonal SOCS1 Primary Antibody for FACS, IF - ABIN652738 : Starr, Willson, Viney, Murray, Rayner, Jenkins, Gonda, Alexander, Metcalf, Nicola, Hilton: A family of cytokine-inducible inhibitors of signalling. in Nature 1997 (PubMed)
    Show all 2 references for 652738

  3. Human Polyclonal SOCS1 Primary Antibody for EIA, WB - ABIN453835 : Minamoto, Ikegame, Ueno, Narazaki, Naka, Yamamoto, Matsumoto, Saito, Hosoe, Kishimoto: Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. in Biochemical and biophysical research communications 1997 (PubMed)
    Show all 2 references for 453835

  4. Human Polyclonal SOCS1 Primary Antibody for ELISA, IHC (p) - ABIN451850 : Nazmi, Mukherjee, Kundu, Dutta, Mahadevan, Shankar, Basu: TLR7 is a key regulator of innate immunity against Japanese encephalitis virus infection. in Neurobiology of disease 2014 (PubMed)

  5. Cow (Bovine) Polyclonal SOCS1 Primary Antibody for IHC, WB - ABIN2777164 : Melzner, Weniger, Bucur, Brüderlein, Dorsch, Hasel, Leithäuser, Ritz, Dyer, Barth, Möller: Biallelic deletion within 16p13.13 including SOCS-1 in Karpas1106P mediastinal B-cell lymphoma line is associated with delayed degradation of JAK2 protein. in International journal of cancer. Journal international du cancer 2006 (PubMed)

More Antibodies against SOCS1 Interaction Partners

Zebrafish Suppressor of Cytokine Signaling 1 (SOCS1) interaction partners

  1. Socs1a transgenic zebrafish have liver steatosis and insulin (show INS Antibodies) resistance.

  2. Studies demonstrate a conserved role for SOCS1 in T cell development and suggest a novel T cell-independent function in embryonic myelopoiesis mediated, at least in part, via its effects on receptors using the Jak2 (show JAK2 Antibodies)-Stat5 (show STAT5B Antibodies) pathway.

  3. in homozygotes, GH signaling is reduced by the action of the SOCS1 and SOCS3 (show SOCS3 Antibodies) proteins.

Rhesus Monkey Suppressor of Cytokine Signaling 1 (SOCS1) interaction partners

  1. SOCS1 alleviates RhTRIM5alpha-mediated regulation in the late phase of HIV-1 life cycle probably due to the destabilization of RhTRIM5alpha.

Rainbow Trout (Oncorhynchus mykiss) Suppressor of Cytokine Signaling 1 (SOCS1) interaction partners

  1. The upregulation of SOCS-1 and SOCS-2 (show SOCS2 Antibodies) by cortisol may be playing a key role in suppressing cytokine signaling and the associated inflammatory response.

Human Suppressor of Cytokine Signaling 1 (SOCS1) interaction partners

  1. Results provide evidence that repression of SHP-1 (show PTPN6 Antibodies), SHP-2 (show PTPN11 Antibodies) and SOCS-1 gene expression in patient plasma cells supports the constitutive activation of the JAK (show JAK3 Antibodies)/STAT3 (show STAT3 Antibodies) pathway and probably leads to higher degrees of bone marrow invasion.

  2. Suppressor of cytokine signaling 1 (SOCS1) expression was upregulated in sustained virological responses (SVR) patients compared with non-SVR patients based on a multiplex reverse transcription-polymerase chain reaction analysis. Peripheral blood SOCS1 expression before treatment was not associated with SVR in hepatitis C virus (HCV) genotype 1 patients treated with pegylated IFN-alpha (show IFNA Antibodies) and ribavirin.

  3. tumor-suppressor functions of SOCS1 in the liver could be mediated, at least partly, via regulation of the expression, stability and subcellular distribution of p21 (show CDKN1A Antibodies) and its paradoxical oncogenic functions, namely, resistance to apoptosis and increased proliferation

  4. Suppressor Of Cytokine Signaling 1 (SOCS1) overexpression in retinal pigment epithelium cells inhibits some IFNgamma-mediated responses that lead to uveitis development. This notion raises the possibility that SOCS1 overexpression could be a novel target for treating non-infectious uveitis.

  5. nectin-4 (show PVRL4 Antibodies) serves as a stimulatory co-receptor for the prolactin receptor (show PRLR Antibodies) by regulating the feedback inhibition of SOCS1 in the JAK2 (show JAK2 Antibodies)-STAT5a (show STAT5A Antibodies) signaling pathway

  6. This study showed that SOCS5 (show SOCS5 Antibodies) expression was significantly down-regulated.

  7. this study shows that IL-7 (show IL7 Antibodies) induces the expression of SOCS1 through the JAK (show JAK3 Antibodies)/STAT-5 (show STAT5A Antibodies) pathway

  8. SOCS1 silencing can inhibit proliferation and induce apoptosis of MV3 and A357 melanoma cells in vivo and in vitro by inhibiting extracellular signal-regulated kinase and janus kinase signal transduction and activators of transcription signaling pathways.

  9. SOCS1 may promote apoptosis of intestinal epithelial cells at least partly through mediating p53 (show TP53 Antibodies) signaling.

  10. The results revealed that although the expression levels of SOCS1, SOCS3 (show SOCS3 Antibodies) and, in particular, pSHP2, tend to decrease in the four types of astrocytomas, PIAS3 (show PIAS3 Antibodies) downregulation is more negatively correlated with STAT3 (show STAT3 Antibodies) activation in the stepwise progress of astrocytomas and would indicate an unfavorable outcome.

Mouse (Murine) Suppressor of Cytokine Signaling 1 (SOCS1) interaction partners

  1. Cell type-specific, different roles for viral immediate early (show JUN Antibodies) or early gene expression and/or viral tegument proteins in the early stimulation of SOCS1 and SOCS3 (show SOCS3 Antibodies) during murine cytomegalovirus infection.

  2. Loss of SOCS3 (show SOCS3 Antibodies) significantly accelerated the pathology and inflammatory disease characteristic of SOCS1 deficiency. We propose a model in which SOCS1 and SOCS3 (show SOCS3 Antibodies) operate independently to control specific cytokine responses and together modulate the proliferation and activation of lymphoid and myeloid cells to prevent rapid inflammatory disease

  3. miR (show MLXIP Antibodies)-155 not only directly inhibited SOCS1 expression, but also increased the expression of p-STAT (show STAT1 Antibodies) and PDCD4 (show PDCD4 Antibodies), as well as the production of proinflammation mediators IL-6 (show IL6 Antibodies) and TNF-alpha (show TNF Antibodies) in atherogenesis.

  4. TLR8 (show TLR8 Antibodies) coupling with SOCS-1 inhibits TLR7 (show TLR7 Antibodies)-mediated antiviral immunity during WNV infection in mice.

  5. nectin-4 (show PVRL4 Antibodies) serves as a stimulatory co-receptor for the prolactin receptor (show PRLR Antibodies) by regulating the feedback inhibition of SOCS1 in the JAK2 (show JAK2 Antibodies)-STAT5a (show STAT5A Antibodies) signaling pathway

  6. this study shows that genetic modification of dendritic cells with SOCS1 affects their activation and maturation, inhibits T-cell proliferation and induces hypo-responsiveness, and prolongs islet allograft survival

  7. SOCS1 may promote apoptosis of intestinal epithelial cells at least partly through mediating p53 (show TP53 Antibodies) signaling.

  8. Kdm5a (show KDM5A Antibodies) associates with p50 (show LSP1 Antibodies) and binds to the Socs1 promoter region in resting natural killer cells.

  9. The miR (show MLXIP Antibodies)-155 inhibitor relieves liver injury by enhancing the expression of SOCS1 and inactivating JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) signaling.

  10. NOS1 (show NOS1 Antibodies)-derived nitric oxide promotes NF-kappaB (show NFKB1 Antibodies) transcriptional activity through inhibition of Socs1.Cys147 and Cys179 are essential for SOCS1 nitrosation and proteasomal degradation.

SOCS1 Antigen Profile

Antigen Summary

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.

Alternative names and synonyms associated with SOCS1

  • suppressor of cytokine signaling 1a (socs1a) antibody
  • suppressor of cytokine signaling 1 (socs1) antibody
  • suppressor of cytokine signaling 1 (SOCS1) antibody
  • suppressor of cytokine signaling 1 (LOC100228306) antibody
  • suppressor of cytokine signaling 1 (socs1-b) antibody
  • suppressor of cytokine signaling 1-like protein (socs1) antibody
  • suppressor of cytokine signaling 1 (Socs1) antibody
  • CIS1 antibody
  • Cish1 antibody
  • Cish7 antibody
  • JAB antibody
  • LOC100228306 antibody
  • Socs-1 antibody
  • SOCS1 antibody
  • socs1b antibody
  • SSI-1 antibody
  • SSI1 antibody
  • TIP3 antibody
  • zgc:91868 antibody

Protein level used designations for SOCS1

suppressor of cytokine signaling 1 , suppressor of cytokine signalling , suppressor of cytokine signaling 1b , suppressor of cytokine signaling 1-like protein , JAK binding protein , JAK-binding protein , STAT induced SH3 protein 1 , STAT-induced STAT inhibitor 1 , TIP-3 , Tec-interacting protein 3 , cytokine-inducible SH2 protein 1 , JAK2-binding protein , cytokine inducible SH2-containing protein 1 , cytokine inducible SH2-containing protein 7

GENE ID SPECIES
445073 Danio rerio
496789 Xenopus (Silurana) tropicalis
711180 Macaca mulatta
737070 Pan troglodytes
100144374 Oryzias latipes
100228306 Taeniopygia guttata
100272210 Oncorhynchus mykiss
100294520 Xenopus laevis
100049621 Takifugu rubripes
8651 Homo sapiens
12703 Mus musculus
416630 Gallus gallus
490006 Canis lupus familiaris
252971 Rattus norvegicus
518795 Bos taurus
100307052 Sus scrofa
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