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anti-Dog (Canine) SOCS1 antibody for Enzyme Immunoassay

Recommended SOCS1 Antibody (supplied by: Log in to see )

Antigen
Suppressor of Cytokine Signaling 1 (SOCS1) Antibodies
  • CIS1
  • cis1
  • CISH1
  • cish1
  • Cish1
  • Cish7
  • jab
  • JAB
  • LOC100228306
  • Socs-1
  • socs-1
  • SOCS-1
  • SOCS1
  • socs1
  • socs1b
  • SSI-1
  • ssi-1
  • SSI1
  • ssi1
  • TIP3
  • tip3
  • zgc:91868
Epitope
C-Term
59
27
13
5
4
3
2
2
2
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
152
66
54
7
7
4
2
2
1
Host
Goat
136
17
11
Clonality
Polyclonal
Conjugate
This SOCS1 antibody is un-conjugated
7
7
6
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
141
55
34
28
11
10
9
7
4
4
2
1
Supplier
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Catalog No. ABIN782868
$ 203.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008820835 ABIN374072 EIA IHC (p) WB Goat C-Term Log in to see Polyclonal 1

Top referenced anti-SOCS1 antibody for Enzyme Immunoassay

Similar anti-SOCS1 Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus) Cow (Bovine) Dog (Canine)
Western Blotting (WB) 134 Antibodies 52 Antibodies 43 Antibodies 8 Antibodies 8 Antibodies
Immunoprecipitation (IP) 5 Antibodies 7 Antibodies 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 30 Antibodies 16 Antibodies 12 Antibodies 3 Antibodies 3 Antibodies
Immunohistochemistry (IHC) 15 Antibodies 35 Antibodies 3 Antibodies 5 Antibodies 12 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies

General

Antigen Suppressor of Cytokine Signaling 1 (SOCS1) Antibodies
Epitope C-Term
(59), (27), (13), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(152), (66), (54), (7), (7), (4), (2), (2), (1)
Host Goat
(136), (17), (11)
Clonality
Polyclonal
Conjugate This SOCS1 antibody is un-conjugated
(7), (7), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(141), (55), (34), (28), (11), (10), (9), (7), (4), (4), (2), (1)
Pubmed 1 reference available
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Product Details anti-SOCS1 Antibody

Target Details SOCS1 Application Details Handling References for anti-SOCS1 Antibody (ABIN782868) Images
Sequence C-VLRDYLSSFP FQI
Specificity Recognizes Suppressor Of Cytokine Signaling 1 (SOCS1) at C-term.
Cross-Reactivity (Details) Species reactivity (expected):Rat, Canine (Dog) and Bovine.
Species reactivity (tested):Human, Mouse.
Purification Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
Immunogen Synthetic peptide from the C-Terminus of Human SOCS1 (NP_003736.1). Genename: SOCS1

Target Details SOCS1

Product Details anti-SOCS1 Antibody Application Details Handling References for anti-SOCS1 Antibody (ABIN782868) Images back to top
Antigen
Alternative Name SOCS1 (SOCS1 Antibody Abstract)
Background SOCS1 represents a family of proteins that regulates responses to cytokines. The SOCS family comprises at least 8 members, SOCS1 to SOCS7 and CIS (cytokine inducible SH2 containing protein). Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C terminal motif named the SOCS box. SOCS1 (also known as Janus kinase binding protein and STAT induced STAT inhibitor 1) was isolated independently by its ability to interact with Janus kinase 2 in a 2 hybrid screen and on the basis of antigenic similarity with the SH2 domain of STAT3. SOCS 1 inhibition of signal transduction appears to occur by binding to and inhibiting the catalytic activity of members of JAK family of cytoplasmic kinases (direct JAK2 kinase inhibition). Biochemical characterization as well as gene disruption studies indicate that SOCS1 is an important negative regulator of JAK-STAT signal pathway.Synonyms: JAB, JAK-binding protein, SOCS-1, SSI-1, SSI1, STAT-induced STAT inhibitor 1, Suppressor of cytokine signaling 1, TIP-3, TIP3, Tec-interacting protein 3
Gene ID 8651
NCBI Accession NP_003736
UniProt O15524
Research Area Chromatin and Nuclear Signaling, Signaling, Cytokines
Pathways JAK-STAT Signaling, Interferon-gamma Pathway, TLR Signaling

Application Details

Product Details anti-SOCS1 Antibody Target Details SOCS1 Handling References for anti-SOCS1 Antibody (ABIN782868) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-SOCS1 Antibody Target Details SOCS1 Application Details References for anti-SOCS1 Antibody (ABIN782868) Images back to top
Concentration 0.5 mg/mL
Buffer Tris saline buffer, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-SOCS1 Antibody (ABIN782868)

Product Details anti-SOCS1 Antibody Target Details SOCS1 Application Details Handling Images back to top
Background publications

Starr, Willson, Viney, Murray, Rayner, Jenkins, Gonda, Alexander, Metcalf, Nicola, Hilton: "A family of cytokine-inducible inhibitors of signalling." in: Nature, Vol. 387, Issue 6636, pp. 917-21, 1997

Images

Product Details anti-SOCS1 Antibody Target Details SOCS1 Application Details Handling References for anti-SOCS1 Antibody (ABIN782868) back to top
Supplier Images
 image for anti-SOCS1 antibody (Suppressor of Cytokine Signaling 1) (C-Term) (ABIN782868) anti-Suppressor of Cytokine Signaling 1 (SOCS1) (C-Term) antibody
 image for anti-SOCS1 antibody (Suppressor of Cytokine Signaling 1) (C-Term) (ABIN782868) anti-Suppressor of Cytokine Signaling 1 (SOCS1) (C-Term) antibody (Image 2)
 image for anti-SOCS1 antibody (Suppressor of Cytokine Signaling 1) (C-Term) (ABIN782868) anti-Suppressor of Cytokine Signaling 1 (SOCS1) (C-Term) antibody (Image 3)