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|Antigen||Suppressor of Cytokine Signaling 1 (SOCS1) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus), Dog (Canine) Alternatives|
|Conjugate||This SOCS1 antibody is un-conjugated Alternatives|
Immunohistochemistry (IHC), Western Blotting (WB)
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Product Details anti-SOCS1 AntibodyTarget Details SOCS1 Application Details Handling Images
|Specificity||SOCS1 antibody was raised against the N terminal of SOCS1|
|Immunogen||SOCS1 antibody was raised using the N terminal of SOCS1 corresponding to a region with amino acids RRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRA|
Target Details SOCS1Product Details anti-SOCS1 Antibody Application Details Handling Images back to top
|Alternative Name||SOCS1 (SOCS1 Antibody Abstract)|
|Background||SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. SOCS1 functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of its gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.|
|Molecular Weight||23 kDa (MW of target protein)|
|Research Area||Chromatin and Nuclear Signaling, Signaling, Cytokines, Growth Factors|
|Pathways||JAK-STAT Signaling, Interferon-gamma Pathway, TLR Signaling, Response to Growth Hormone Stimulus|
Application DetailsProduct Details anti-SOCS1 Antibody Target Details SOCS1 Handling Images back to top
WB: 1.25 µg/mL, IHC: 4-8 µg/mL
Optimal conditions should be determined by the investigator.
SOCS1 Blocking Peptide, catalog no. 33R-8152, is also available for use as a blocking control in assays to test for specificity of this SOCS1 antibody
|Restrictions||For Research Use only|
HandlingProduct Details anti-SOCS1 Antibody Target Details SOCS1 Application Details Images back to top
|Reconstitution||Lyophilized powder. Add distilled water for a 1 mg/mL concentration of SOCS1 antibody in PBS|
Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.
|Storage Comment||Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.|
ImagesProduct Details anti-SOCS1 Antibody Target Details SOCS1 Application Details Handling back to top