anti-Human SOCS1 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended SOCS1 Antibody (supplied by: Log in to see )

Antigen
Suppressor of Cytokine Signaling 1 (SOCS1) Antibodies
  • socs1
  • zgc:91868
  • jab
  • cis1
  • ssi1
  • tip3
  • cish1
  • ssi-1
  • socs-1
  • SOCS1
  • LOC100228306
  • socs1b
  • CIS1
  • CISH1
  • JAB
  • SOCS-1
  • SSI-1
  • SSI1
  • TIP3
  • Cish1
  • Cish7
  • Socs-1
  • suppressor of cytokine signaling 1a
  • suppressor of cytokine signaling 1
  • suppressor of cytokine signaling 1-like protein
  • socs1a
  • socs1
  • SOCS1
  • LOC100228306
  • socs1-b
  • Socs1
Epitope
AA 160-211
56
22
14
7
5
3
3
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
161
96
76
12
10
8
6
5
4
4
3
1
Host
Rabbit
142
20
13
Clonality
Polyclonal
Conjugate
This SOCS1 antibody is un-conjugated
11
7
6
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
148
54
37
32
13
12
12
6
6
5
4
2
Options
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Catalog No. ABIN725135
$ 295.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2806550 IF (p) Alexa Fluor 594 Rabbit IgG AA 160-211 Log in to see Polyclonal
1 ABIN725139 IF (p) Cy5 Rabbit IgG AA 160-211 Log in to see Polyclonal
1 ABIN725142 IF (p) FITC Rabbit IgG AA 160-211 Log in to see Polyclonal
1 ABIN725138 IF (p) Cy3 Rabbit IgG AA 160-211 Log in to see Polyclonal
1 ABIN725141 IF (p) Cy7 Rabbit IgG AA 160-211 Log in to see Polyclonal
1 ABIN725140 IF (p) Cy5.5 Rabbit IgG AA 160-211 Log in to see Polyclonal
1 ABIN916019 IF (p) Alexa Fluor 555 Rabbit IgG AA 160-211 Log in to see Polyclonal
1 ABIN916015 IF (p) Alexa Fluor 488 Rabbit IgG AA 160-211 Log in to see Polyclonal
1 ABIN916016 IF (p) Alexa Fluor 350 Rabbit IgG AA 160-211 Log in to see Polyclonal
1 ABIN916018 IF (p) Alexa Fluor 647 Rabbit IgG AA 160-211 Log in to see Polyclonal
1 ABIN5010817 IF (p) Alexa Fluor 680 Rabbit IgG AA 160-211 Log in to see Polyclonal
1 ABIN5010818 IF (p) Alexa Fluor 750 Rabbit IgG AA 160-211 Log in to see Polyclonal

General

Antigen Suppressor of Cytokine Signaling 1 (SOCS1) Antibodies
Epitope AA 160-211
(56), (22), (14), (7), (5), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(161), (96), (76), (12), (10), (8), (6), (5), (4), (4), (3), (1)
Host Rabbit
(142), (20), (13)
Clonality
Polyclonal
Conjugate This SOCS1 antibody is un-conjugated
(11), (7), (6), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(148), (54), (37), (32), (13), (12), (12), (6), (6), (5), (4), (2)
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Product Details anti-SOCS1 Antibody

Target Details SOCS1 Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human Socs 1
Isotype IgG

Target Details SOCS1

Product Details anti-SOCS1 Antibody Application Details Handling Images back to top
Antigen
Alternative Name SOCS1 (SOCS1 Antibody Abstract)
Background

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

Subcellular location: Nucleus

Synonyms: JAB, CIS1, SSI1, TIP3, CISH1, SSI-1, SOCS-1, Suppressor of cytokine signaling 1, JAK-binding protein, STAT-induced STAT inhibitor 1, Tec-interacting protein 3, TIP-3, SOCS1

Gene ID 8651
UniProt O15524
Research Area Chromatin and Nuclear Signaling, Signaling, Cytokines
Pathways JAK-STAT Signaling, Interferon-gamma Pathway, TLR Signaling, Response to Growth Hormone Stimulus

Application Details

Product Details anti-SOCS1 Antibody Target Details SOCS1 Handling Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-SOCS1 Antibody Target Details SOCS1 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-SOCS1 Antibody Target Details SOCS1 Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Suppressor of Cytokine Signaling 1 (SOCS1) (AA 160-211) antibody (ABIN725135) Formalin-fixed and paraffin embedded: rat brain tissue labeled with Anti-SOCS 1 Polyc...
Immunohistochemistry (IHC) image for anti-Suppressor of Cytokine Signaling 1 (SOCS1) (AA 160-211) antibody (ABIN725135) Formalin-fixed and paraffin embedded human colon cancer labeled with Anti-Socs1Polycl...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Suppressor of Cytokine Signaling 1 (SOCS1) (AA 160-211) antibody (ABIN725135) Formalin-fixed and paraffin embedded: rat brain tissue labeled with Anti-SOCS 1 Polyc...