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anti-Rat (Rattus) SOCS2 antibody for ELISA

Recommended SOCS2 Antibody (supplied by: Log in to see )

Antigen
Suppressor of Cytokine Signaling 2 (SOCS2) Antibodies
  • 8030460M17
  • AI527257
  • AW108012
  • cis2
  • CIS2
  • cish2
  • Cish2
  • D130043N08Rik
  • hg
  • JAB
  • si:dkey-202b22.1
  • Socs-2
  • SOCS-2
  • socs-2
  • socs2
  • ssi-2
  • SSI-2
  • SSI2
  • ssi2
  • stati2
  • STATI2
Epitope
AA 184-198
15
5
5
4
3
2
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
50
18
16
3
3
2
2
Host
Rabbit
46
5
2
Clonality
Polyclonal
Conjugate
This SOCS2 antibody is un-conjugated
1
1
Application
ELISA, Western Blotting (WB)
37
13
10
10
8
1
1
1
1
Supplier
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Catalog No. ABIN269520
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0012092679 ABIN1453938 ELISA WB Rabbit IgG Internal Region Log in to see Polyclonal
0.0012092679 ABIN3187019 ELISA WB Rabbit IgG Internal Region Log in to see Polyclonal
0.0012092679 ABIN2428729 IHC ELISA Rabbit IgG Log in to see Polyclonal
0.0012092679 ABIN1871055 ICC IHC (fro) IHC (p) ELISA WB Rabbit IgG Log in to see Polyclonal

Top referenced anti-SOCS2 antibody for ELISA

Similar anti-SOCS2 Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus)
Western Blotting (WB) 34 Antibodies 15 Antibodies 15 Antibodies
Immunoprecipitation (IP) 10 Antibodies 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 9 Antibodies 1 Antibodies 2 Antibodies
Immunohistochemistry (IHC) 8 Antibodies 4 Antibodies 4 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 1 Antibodies 1 Antibodies 1 Antibodies
Immunocytochemistry (ICC) 1 Antibodies

General

Antigen Suppressor of Cytokine Signaling 2 (SOCS2) Antibodies
Epitope AA 184-198
(15), (5), (5), (4), (3), (2), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(50), (18), (16), (3), (3), (2), (2)
Host Rabbit
(46), (5), (2)
Clonality
Polyclonal
Conjugate This SOCS2 antibody is un-conjugated
(1), (1)
Application ELISA, Western Blotting (WB)
(37), (13), (10), (10), (8), (1), (1), (1), (1)
Pubmed 8 references available
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Product Details anti-SOCS2 Antibody

Target Details SOCS2 Application Details Handling References for anti-SOCS2 Antibody (ABIN269520) Images
Specificity SOCS2
Cross-Reactivity (Details) Not yet tested in other species.
Purification affinity purified
Immunogen Synthetic peptide (PTRLKDYLEEYKFQV) correspondingto amino acids 184-198 of human, rat and mouse SOCS 2 (NP_003868)
Isotype IgG

Target Details SOCS2

Product Details anti-SOCS2 Antibody Application Details Handling References for anti-SOCS2 Antibody (ABIN269520) Images back to top
Antigen
Alternative Name SOCS-2 (SOCS2 Antibody Abstract)
Background Accumulating evidence demonstrates that cytokine receptorsignaling is negativelyregulated by a family of Srchomology 2 domain-containing adaptor moleculesTermedSOCS (Suppressor of Cytokine Signaling). To date, there are eight members ofSOCS family have beenrecognized, they are SOCS 1, 2, 3, 4, 5, 6, 7 and CIS.Structurally the SOCS proteins are composed of an Nterminalregion of variable lengthand amino acidcomposition, a central SH2 domain, and a previouslyunrecognizedC-terminal motif that we have called the SOCS box. The SOCS proteins appear to formpart of aclassical negative feed back loop that regulates cytokinesignal transduction viaa STAT induced transcriptionalmechanism. Transcription of each of the SOCSgenesoccurs rapidly in vitro and in vivo in response to cytokines, and once produced,the various members of the SOCSfamily appear to inhibit signaling in different ways.SOCS 2, not like SOCS 1 and SOCS 3, regulates postnatalgrowth, likely through itsability to influence the GH / IGF 1axis, although they might have overlapping actions. Alternate Names: anti-CIS 2 antibody, anti-CIS2 antibody, anti-Cish 2 antibody, anti-Cish2 antibody,anti-Cytokine inducible SH2 protein 2 antibody, anti-SOCS 2 antibody, anti-SSI 2antibody, anti-SSI2 antibody, anti-STAT induced STAT inhibitor 2 antibody, anti-STATI 2antibody, anti-STATI2 antibody, anti-Suppressor of cytokine signaling 2 antibody.
Gene Symbol: SOCS2
Gene ID 8835
NCBI Accession NP_003868
Pathways JAK-STAT Signaling

Application Details

Product Details anti-SOCS2 Antibody Target Details SOCS2 Handling References for anti-SOCS2 Antibody (ABIN269520) Images back to top
Application Notes Recommended dilutions: ELISA 1:5000-1:20000, Western Blot 1:500-1:1000
Restrictions For Research Use only

Handling

Product Details anti-SOCS2 Antibody Target Details SOCS2 Application Details References for anti-SOCS2 Antibody (ABIN269520) Images back to top
Concentration 0.2 mg/mL
Buffer PBS, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Do not freeze.
Storage 4 °C

References for anti-SOCS2 Antibody (ABIN269520)

Product Details anti-SOCS2 Antibody Target Details SOCS2 Application Details Handling Images back to top
Product cited in:

Inagaki, Lin, Goetz, Mohammadi, Mangelsdorf, Kliewer: "Inhibition of growth hormone signaling by the fasting-induced hormone FGF21." in: Cell metabolism, Vol. 8, Issue 1, pp. 77-83, 2008

Ransome, Turnley: "Analysis of neuronal subpopulations in mice over-expressing suppressor of cytokine signaling-2." in: Neuroscience, Vol. 132, Issue 3, pp. 673-87, 2005

Gregorieff, Pyronnet, Sonenberg, Veillette: "Regulation of SOCS-1 expression by translational repression." in: The Journal of biological chemistry, Vol. 275, Issue 28, pp. 21596-604, 2000

Ram, Waxman: "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms." in: The Journal of biological chemistry, Vol. 274, Issue 50, pp. 35553-61, 2000

Background publications

Krebs, Hilton: "SOCS proteins: negative regulators of cytokine signaling." in: Stem cells (Dayton, Ohio), Vol. 19, Issue 5, pp. 378-87, 2001

Krebs, Hilton: "SOCS: physiological suppressors of cytokine signaling." in: Journal of cell science, Vol. 113 ( Pt 16), pp. 2813-9, 2000

Yoshimura: "The CIS family: negative regulators of JAK-STAT signaling." in: Cytokine & growth factor reviews, Vol. 9, Issue 3-4, pp. 197-204, 1999

Hilton, Richardson, Alexander, Viney, Willson, Sprigg, Starr, Nicholson, Metcalf, Nicola: "Twenty proteins containing a C-terminal SOCS box form five structural classes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 1, pp. 114-9, 1998