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anti-Mouse (Murine) SOCS5 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended SOCS5 Antibody (supplied by: Log in to see )

Antigen
Suppressor of Cytokine Signaling 5 (SOCS5) Antibodies
  • 1810018L08Rik
  • CIS6
  • cis6
  • Cish5
  • cish5
  • CISH6
  • cish6
  • GB18949
  • mKIAA0671
  • RGD1564914
  • SOCS-5
  • socs-5
  • socs5
  • SOCS5
  • zgc:153506
Reactivity
Human, Mouse (Murine), Rat (Rattus)
63
28
22
2
2
1
1
Host
Rabbit
41
14
8
Clonality
Polyclonal
Conjugate
This SOCS5 antibody is conjugated to Alexa Fluor 647
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
45
22
10
10
8
2
1
1
1
1
Supplier
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Supplier Product No.
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Catalog No. ABIN1698589
$ 357.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.00088487717 ABIN1705837 IF (p) Cy5.5 Rabbit IgG Log in to see Polyclonal
0.00088487717 ABIN1704026 IF (p) Cy5 Rabbit IgG Log in to see Polyclonal
0.00088487717 ABIN1694951 IF (p) Alexa Fluor 488 Rabbit IgG Log in to see Polyclonal
0.00088487717 ABIN1696778 IF (p) Alexa Fluor 555 Rabbit IgG Log in to see Polyclonal
0.00088487717 ABIN1693135 IF (p) Alexa Fluor 350 Rabbit IgG Log in to see Polyclonal
0.00088487717 ABIN1707795 IF (p) Cy7 Rabbit IgG Log in to see Polyclonal
0.00088487717 ABIN1702215 IF (p) Cy3 Rabbit IgG Log in to see Polyclonal
0.00088487717 ABIN1709606 IF (p) FITC Rabbit IgG Log in to see Polyclonal
0.00088487717 ABIN2806551 IF (p) Alexa Fluor 594 Rabbit IgG Log in to see Polyclonal
0.00088487717 ABIN1713904 IF (p) IHC (p) WB Rabbit IgG Log in to see Polyclonal

Similar anti-SOCS5 Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus)
Western Blotting (WB) 46 Antibodies 15 Antibodies 9 Antibodies
Immunoprecipitation (IP) 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 11 Antibodies 4 Antibodies 3 Antibodies
Immunohistochemistry (IHC) 9 Antibodies 2 Antibodies 2 Antibodies
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) 1 Antibodies
Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)) 1 Antibodies 1 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies 11 Antibodies 11 Antibodies

General

Antigen Suppressor of Cytokine Signaling 5 (SOCS5) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(63), (28), (22), (2), (2), (1), (1)
Host Rabbit
(41), (14), (8)
Clonality
Polyclonal
Conjugate This SOCS5 antibody is conjugated to Alexa Fluor 647
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p))
(45), (22), (10), (10), (8), (2), (1), (1), (1), (1)
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Product Details anti-SOCS5 Antibody

Target Details SOCS5 Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human SOCS5
Isotype IgG

Target Details SOCS5

Product Details anti-SOCS5 Antibody Application Details Handling Images back to top
Antigen
Alternative Name Socs5 (SOCS5 Antibody Abstract)
Background

The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. During Th1 differentiation a reduction in the association of Jak1 with the IL4 Receptor correlated with the appearance of SOCS5. SOCS5 protein was preferentially expressed in committed Th1 cells and interacted with the cytoplasmic region of the IL4 Receptor alpha chain irrespective of receptor tyrosine phosphorylation. This unconventional interaction of SOCS5 protein with IL4 Receptor resulted in the inhibition of IL4-mediated signal transducer and activator of transcription-6 activation. T cells from transgenic mice constitutively expressing SOCS5 exhibited a significant reduction of IL4-mediated Th2 development. Therefore, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance.


Synonyms: CIS-6, CIS6, CISH5, CISH6, Cytokine inducible SH2 containing protein 5, Cytokine inducible SH2 protein 6, KIAA0671, SOCS-5, Suppressor of cytokine signaling 5.
Research Area Signaling, Innate Immunity, Cytokines
Pathways JAK-STAT Signaling, EGFR Signaling Pathway

Application Details

Product Details anti-SOCS5 Antibody Target Details SOCS5 Handling Images back to top
Application Notes IF(IHC-P)(1:50-200)
Comment

Exitation/Emission: 652nm/668nm

Restrictions For Research Use only

Handling

Product Details anti-SOCS5 Antibody Target Details SOCS5 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at 4°C
Expiry Date 12 months