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This study showed that SOCS5 expression was significantly down-regulated.
Opisthorchis felineus infection diminishes the risk of atopic bronchial asthma associated with the SOCS5 gene polymorphism.
different domains in SOCS5 contribute to two distinct mechanisms for regulation of cytokine and growth factor signaling with JAK1 (show JAK1 ELISA Kits) and SHC-1 (show SHC1 ELISA Kits)
The rs6737848 SOCS5 polymorphism was significantly associated with asthma in additive model and in dominant model
Exogenous miR (show MLXIP ELISA Kits)-9 effectively reduced SOCS5 levels, leading to activated JAK (show JAK3 ELISA Kits)-STAT (show STAT1 ELISA Kits) pathway, which promoted endothelial cell migration and tumour angiogenesis
Identified is a conserved region of about 70 residues in the N-terminal domains of SOCS4 (show SOCS6 ELISA Kits) and 5 that is predicted to be more ordered than the surrounding sequence.
The results may contribute to understanding SOCS5 and SOCS6 (show SOCS6 ELISA Kits) expression regulation in various cancer tissues, and show that these two factors may be used for diagnosing cancer.
Up regulation of SOCS1 (show SOCS1 ELISA Kits) and SOCS5 expression and down-regulation of SOCS3 (show SOCS3 ELISA Kits) and CIS (show CISH ELISA Kits) may correlate with the development of a Th1 (show TH1L ELISA Kits) mediated immune response in Vogt-Koyanagi-Harada disease.
The reduction in EGFR (show EGFR ELISA Kits) levels and EGF (show EGF ELISA Kits)-induced signaling in SOCS5-expressing cells requires both the Src (show SRC ELISA Kits) homology-2 and SOCS (show CISH ELISA Kits) box domains of SOCS5.
Constitutive expression of SOCS5 in transgenic mice results in reduced eosinophil infiltration in allergic conjunctivitis
this study shows that DRD3 (show DRD3 ELISA Kits) signaling evokes Socs5 expression, a negative regulator of Th2 development, which indirectly favors acquisition of Th1 (show HAND1 ELISA Kits) phenotype
have identified a phosphorylation site (Ser211) within the JIR of mSOCS5 and have investigated the role of phosphorylation in modulating JAK (show JAK3 ELISA Kits) binding using site-directed mutagenesis.
Identified is a conserved region of about 70 residues in the N-terminal domains of Socs4 (show SOCS6 ELISA Kits) and 5 that is predicted to be more ordered than the surrounding sequence.
The effect of Flt3 (show FLT3 ELISA Kits)-L on Th17 cells and expression of suppressors of cytokine signaling (SOCS (show CISH ELISA Kits)) proteins in the lungs of house dust mite (HDM (show HDAC3 ELISA Kits))-sensitized and -challenged mice, was evaluated.
SOCS5 regulates Th1 (show HAND1 ELISA Kits)/Th2 cell balance and suppresses IL-4 (show IL4 ELISA Kits)
SOCS5-deficient CD4 (show CD4 ELISA Kits) T cells showed no abnormalities in Th1 (show HAND1 ELISA Kits)/Th2 differentiation and Socs5(-/-) mice showed normal resistance to infection with Leishmania major.
SOCS-5 associated with the EGF-R (show EGFR ELISA Kits) complex in an EGF (show EGF ELISA Kits)-independent manner
Adoptive transfer of SOCS5Tg-CD4 (show CD4 ELISA Kits)+ T cells into T- and B cell-deficient RAG-2 (show RAG2 ELISA Kits)(-/-) mice resulted in augmented leukocyte infiltration and increased peritoneal levels of IL-12 (show IL12A ELISA Kits), IFN-gamma (show IFNG ELISA Kits), and TNF-alpha (show TNF ELISA Kits) after cecal ligation and puncture
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.
suppressor of cytokine signaling 5
, suppressor of cytokine signaling 5-like
, cytokine-inducible SH2 protein 6
, cytokine-inducible SH2-containing protein 5
, cytokine inducible SH2-containing protein 5