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anti-Mouse (Murine) SOCS6 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended SOCS6 Antibody (supplied by: Log in to see )

Antigen
Suppressor of Cytokine Signaling 6 (SOCS6) Antibodies
  • 1500012M23Rik
  • 5830401B18Rik
  • AI447482
  • CIS-4
  • CIS4
  • Cis4
  • Cish4
  • HSPC060
  • MGC81477
  • SOCS-4
  • SOCS-6
  • Socs4
  • SOCS4
  • SOCS6
  • socs6
  • SSI4
  • STAI4
  • STATI4
Epitope
C-Term
20
15
9
6
6
3
2
1
Reactivity
Human, Mouse (Murine)
50
9
5
Host
Rabbit
42
7
1
Clonality
Polyclonal
Conjugate
This SOCS6 antibody is un-conjugated
2
2
2
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
40
29
23
5
1
Supplier
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Catalog No. ABIN373895
$ 599.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008982679 ABIN444521 IHC (p) IHC Rabbit IgG C-Term Log in to see Polyclonal

Similar anti-SOCS6 Antibodies

Application / Reactivity Human Mouse (Murine)
Western Blotting (WB) 40 Antibodies 6 Antibodies
Immunoprecipitation (IP) 1 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 6 Antibodies 2 Antibodies
Immunohistochemistry (IHC) 23 Antibodies 5 Antibodies
ELISA 29 Antibodies 4 Antibodies

General

Antigen Suppressor of Cytokine Signaling 6 (SOCS6) Antibodies
Epitope C-Term
(20), (15), (9), (6), (6), (3), (2), (1)
Reactivity Human, Mouse (Murine)
(50), (9), (5)
Host Rabbit
(42), (7), (1)
Clonality
Polyclonal
Conjugate This SOCS6 antibody is un-conjugated
(2), (2), (2), (2), (2), (2)
Application Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(40), (29), (23), (5), (1)
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Product Details anti-SOCS6 Antibody

Target Details SOCS6 Application Details Handling Images
Specificity This antibody recognizes SOCS-6.
Cross-Reactivity (Details) Species reactivity (expected):Mouse.
Species reactivity (tested):Human.
Purification Immunoaffinity Chromatography
Immunogen Synthetic peptide corresponding to C-terminal of human SOCS-6 protein.

Target Details SOCS6

Product Details anti-SOCS6 Antibody Application Details Handling Images back to top
Antigen
Alternative Name SOCS6 / CIS4 (SOCS6 Antibody Abstract)
Background The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS1 and SOCS6 interact with the insulin receptor (IR) when expressed in human hepatoma cells (HepG2) or in rat hepatoma cells overexpressing human IR. SOCS1 and SOCS6 inhibit insulin-dependent activation of ERK1/2 and protein kinase B in vivo and IR- directed phosphorylation of IRS1 in vitro. These results suggest that SOCS proteins may be inhibitors of IR signalling and could mediate cytokine-induced insulin resistance and contribute to the pathogenesis of type II diabetes.Synonyms: CIS-4, Cytokine-inducible SH2 protein 4, SOCS-4, SOCS-6, SOCS4, Suppressor of cytokine signaling 4, Suppressor of cytokine signaling 6
Molecular Weight 60-67 kDa
Gene ID 9306, 9606
UniProt O14544
Pathways JAK-STAT Signaling

Application Details

Product Details anti-SOCS6 Antibody Target Details SOCS6 Handling Images back to top
Application Notes Western Blot: 1-2 μg/mL. Immunohistochemistry on paraffin sections: 1/100 for 30 min at RT, Staining offormalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Positive Control: A431 and HeLa cells. Placenta
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-SOCS6 Antibody Target Details SOCS6 Application Details Images back to top
Format Liquid
Concentration 0,2 mg/mL
Buffer PBS, pH 7.6 with 1 % BSA and 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!

Images

Product Details anti-SOCS6 Antibody Target Details SOCS6 Application Details Handling back to top
Supplier Images
 image for anti-SOCS6 antibody (Suppressor of Cytokine Signaling 6) (C-Term) (ABIN373895) anti-Suppressor of Cytokine Signaling 6 (SOCS6) (C-Term) antibody