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|Application / Reactivity||Human|
|Confocal Microscopy (CM)||2 Antibodies|
|Dot Blot (DB)||20 Antibodies|
|Flow Cytometry (FACS)||13 Antibodies|
|Immunochromatography (IC)||4 Antibodies|
|Immunocytochemistry (ICC)||4 Antibodies|
|Immunofluorescence (IF)||35 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||25 Antibodies|
|Immunohistochemistry (IHC)||150 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||27 Antibodies|
|Immunoprecipitation (IP)||20 Antibodies|
|Intracellular Staining (ICS)||6 Antibodies|
|Proximity Ligation Assay (PLA)||1 Antibodies|
|Western Blotting (WB)||315 Antibodies|
|Antigen||V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) Antibodies|
|Epitope||N-Term, AA 24-52 Alternatives|
|Conjugate||This SRC antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-SRC AntibodyTarget Details SRC Application Details Handling References for anti-SRC Antibody (ABIN1881833) Images
|Predicted Reactivity||Mouse (Murine)|
|Purification||This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Immunogen||This SRC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-52 amino acids from the N-terminal region of human SRC.|
Target Details SRCProduct Details anti-SRC Antibody Application Details Handling References for anti-SRC Antibody (ABIN1881833) Images back to top
|Alternative Name||SRC (SRC Antibody Abstract)|
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
Synonyms: SRC, SRC1, Proto-oncogene tyrosine-protein kinase Src, Proto-oncogene c-Src, pp60c-src
|NCBI Accession||NP_938033, NP_005408|
|Pathways||JAK-STAT Signaling, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-SRC Antibody Target Details SRC Handling References for anti-SRC Antibody (ABIN1881833) Images back to top
|Application Notes||WB: 1:2000,IHC: 1:50,FACS: 1:50,IF: 1:50|
|Restrictions||For Research Use only|
HandlingProduct Details anti-SRC Antibody Target Details SRC Application Details References for anti-SRC Antibody (ABIN1881833) Images back to top
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.|
|Precaution of Use||WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.|
References for anti-SRC Antibody (ABIN1881833)Product Details anti-SRC Antibody Target Details SRC Application Details Handling Images back to top
|Product cited in:||
Kieslinger, Hiechinger, Dobreva et al.: "Early B cell factor 2 regulates hematopoietic stem cell homeostasis in a cell-nonautonomous manner." in: Cell stem cell, Vol. 7, Issue 4, pp. 496-507, 2010 (PubMed).
Dergai, Tsyba, Dergai et al.: "Microexon-based regulation of ITSN1 and Src SH3 domains specificity relies on introduction of charged amino acids into the interaction interface." in: Biochemical and biophysical research communications, Vol. 399, Issue 2, pp. 307-12, 2010 (PubMed).
Pradhan, Alrehani, Patel et al.: "Cross-talk between serine/threonine protein phosphatase 2A and protein tyrosine phosphatase 1B regulates Src activation and adhesion of integrin αIIbβ3 to fibrinogen." in: The Journal of biological chemistry, Vol. 285, Issue 38, pp. 29059-68, 2010 (PubMed).
Liu, Qiu, Li et al.: "Human phosphatidylethanolamine-binding protein 4 promotes transactivation of estrogen receptor alpha (ERalpha) in human cancer cells by inhibiting proteasome-dependent ERalpha degradation via ..." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 21934-42, 2010 (PubMed).
Pene-Dumitrescu, Smithgall: "Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner." in: The Journal of biological chemistry, Vol. 285, Issue 28, pp. 21446-57, 2010 (PubMed).
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