You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our SRC Proteins (SRC)

Full name:
V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) Proteins (SRC)
On are 13 V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) Proteins from 8 different suppliers available. Additionally we are shipping SRC Antibodies (417) and SRC Kits (17) and many more products for this protein. A total of 472 SRC products are currently listed.
ASV, AW259666, c-Src, C-src1, CG7524, D-src, D-Src64B, Dmel\CG7524, DmHD-358, Dm SRC1, dsrc, Dsrc64, Dsrc64B, HD-358, MRE5, p60-Src, PP60C-SCR, pp60c-src, SDR, src, SRC1, src64, SRC 64B, src64b
list all proteins Gene Name GeneID UniProt
SRC 20779 P05480
SRC 6714 P12931
SRC 83805  

Show all synonyms

SRC Proteins (SRC) by Origin

Select your origin of interest

Top referenced SRC Proteins

  1. Mouse (Murine) SRC Protein expressed in Baculovirus infected Insect Cells - ABIN2007642 : Czernilofsky, Levinson, Varmus, Bishop, Tischer, Goodman: Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product. in Nature 1981 (PubMed)
    Show all 3 references for ABIN2007642

  2. Human SRC Protein expressed in Baculovirus infected Insect Cells - ABIN2003349 : Ma, Zhang: Lithium reduced N-methyl-D-aspartate receptor subunit 2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral ischemia. in Neuroscience letters 2003 (PubMed)
    Show all 3 references for ABIN2003349

More Proteins for SRC Interaction Partners

Mouse (Murine) V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) interaction partners

  1. results suggest that LPS (show TLR4 Proteins)-stimulated macrophage mediators attenuate both FAK (show PTK2 Proteins) and Src activations in osteoblast, suggesting a novel role for TNFalpha (show TNF Proteins) on osteoblast performance

  2. Src has a role in priming Pyk2 (show PTK2B Proteins) (but not FAK (show PTK2 Proteins)) phosphorylation and subsequent activation downstream of integrins

  3. Heritable pulmonary arterial hypertension (PAH) results from increased SRC activation, cellular contraction, and vascular resistance, but antagonism of HTR2B prevents SRC phosphorylation and development of PAH.

  4. Periodic axial motility of epithelial basal cell projections is controlled by c-Src.

  5. mutation of the five Src-modified residues to aspartate but not phenylalanine allows Runx1 (show RUNX1 Proteins) to increase Cebpa (show CEBPA Proteins) and granulocyte colony formation by Runx1 (show RUNX1 Proteins)-deleted murine marrow.

  6. This study provides an additional mechanistic link between Angiotensin II and vasoconstriction via SFK-enhanced MLC phosphorylation in smooth muscle cells.

  7. Src/Syk (show SYK Proteins)-dependent signalling stabilises platelet adhesion to podoplanin (show PDPN Proteins)

  8. FAK (show PTK2 Proteins)-regulated signalling module PDK1 (show PDPK1 Proteins)-Akt (show AKT1 Proteins)-p70S6K (show RPS6KB1 Proteins) that controls Src's intracellular trafficking operates at Src-containing autophagosomes.

  9. suggest that Reelin (show RELN Proteins)-dependent signaling mechanisms may be split into Src-AKT (show AKT1 Proteins)-dependent and Src-Go-dependent pathways

  10. Src contributed to tyrosine phosphorylation of ELMO1 at Y720 and Y724 residues, which was crucial for activation of Rac1, followed by the promoting cell adhesion, spreading, and migration.

Fruit Fly (Drosophila melanogaster) V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) interaction partners

  1. Src64 controls actin dynamics to mediate proper ring canal formation during incomplete cytokinesis during germline cyst development in vivo

  2. that Brat represses the translation of src64B, an upstream regulator of a conserved Rho-dependent pathway previously shown to promote axon retraction

  3. Results show that Src42a and Src64b are required for the normal division capacity of Drosophila intestinal progenitor cells, and that these genes as well as Ack cause progenitor overproliferation in the intestine via core cell cycle activation.

  4. a novel essential role for Src in intestinal stem/progenitor cell proliferation and tumourigenesis initiation in vivo.

  5. Data show that the actin-Capping Protein (show TMOD4 Proteins) (CP) alphabeta heterodimer, which regulates actin (show ACTB Proteins) filament (F-actin (show ACTB Proteins)) polymerization, limits Src-induced apoptosis or tissue overgrowth by restricting JNK (show MAPK8 Proteins) activation.

  6. Dumbfounded/Neph1 (show NEPH1 Proteins), a key diaphragm constituent, is a target of the Src kinase (show CSK Proteins) Src64B. Loss of Src64B activity leads to a reduction in the number of diaphragms, and this effect is in part mediated by loss of Dumbfounded/Neph1 (show NEPH1 Proteins) tyrosine phosphorylation.

  7. Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B in the developing embryonic central nervous system.

  8. E4orf4 has a role in inducing PP2A (show PPP2R2B Proteins)- and Src-dependent cell death while inhibiting classic apoptosis pathways in Drosophila melanogaster

  9. Mutations in a Drosophila src gene, src64, that alter the three HRD amino acids, were identified.

  10. Src64B overexpression induced the formation of specialized haemocytes (lamellocytes), but had no effect on circulating plasmatocyte concentration. Src64B overexpression induced F-actin (show ACTB Proteins) formation and Jun kinase (show MAPK9 Proteins) activation in plasmatocytes.

Human V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) interaction partners

  1. Src expression showed a significantly positive linear relationship with RANK, suggesting a potential mechanism of the RANKL (show TNFSF11 Proteins)-RANK axis in regulating breast cancer cell differentiation and antiapoptosis.

  2. Data suggest 17beta-estradiol stimulates odontoblastic differentiation of dental pulp via coordinated regulation of estrogen receptor alpha (show ESR1 Proteins), c-Src, and MAP kinase (show MAPK1 Proteins) signaling pathways, which may play key role in calcification/regeneration of dentin.

  3. This study describes a pro-metastatic EGFR (show EGFR Proteins)/Src-dependent beta4 integrin/FAK (show PTK2 Proteins) complex that is involved in breast cancer malignancy and is a novel therapeutic target for triple-negative breast cancer.

  4. FGF-2 (show FGF2 Proteins), VEGF-A (show VEGFA Proteins), and HIV-Tat (show TAT Proteins), may affect the glomerular filtration barrier in HIV+ children through the induction of synergistic changes in Rho-A (show RHOA Proteins) and Src activity

  5. our integrative approach enabled the discovery of a new model where Src is de-activated in coordination with membrane protrusion, providing important insights into the regulation of endothelial migration and angiogenesis.

  6. Data show that src kinases (SRC) and mitogen-activated protein kinase kinase 1 (MEK (show MAP2K1 Proteins)) co-inhibition by saracatinib and PD0325901 respectively can be broadly effective in tumor growth control of a wide panel of non-small cell lung cancer (NSCLC) cell lines.

  7. Collectively, our data demonstrate that DCMF induces cell migration and promotes wound healing through activation of Src/FAK (show PTK2 Proteins), ERK (show EPHB2 Proteins), AKT (show AKT1 Proteins), and p38 MAPK (show MAPK14 Proteins) signaling.

  8. In marked contrast to invadopodia, this degradation does not require the action of Src kinase (show CSK Proteins), Cdc42 (show CDC42 Proteins) or Dyn2 (show DNM2 Proteins). Rather, inhibition of Dyn2 (show DNM2 Proteins) causes a marked upregulation of stromal matrix degradation

  9. Data suggest that Src kinases inhibitors may act with different mechanisms in non-small cell lung cancer (NSCLC) depending on EGF receptor (EGFR (show EGFR Proteins))/Ras protein (Ras) mutational profile.

  10. regulation of c-Src trafficking requires both microtubules and actin polymerization, and GEF-H1 coordinates c-Src trafficking, acting as a molecular switch between these two mechanisms

Cow (Bovine) V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) interaction partners

  1. RhoA (show RHOA Proteins) and membrane fluidity mediates the spatially polarized Src/FAK (show PTK2 Proteins) activation in response to shear stress.

  2. AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.

  3. The Src gene possibly contributed to conducting association analysis and can be recognized as genetic marker in milk production traits and other performance for animal breeding and genetics.

  4. src has a role in activation of 5'-AMP (show TMPRSS5 Proteins)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells

  5. results indicate that integrin engagement disrupts VE-cadherin-containing adherens junctions via the activation of Src, but not Ras, possibly as a result of modulation of the actin network

  6. These results suggest that TGF-beta1 (show TGFB1 Proteins)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK (show PTK2 Proteins)/Src-dependent and -independent pathways.

Pig (Porcine) V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) interaction partners

  1. Src kinase (show CSK Proteins) mediates hypoxia-induced caspase-1 (show CASP1 Proteins) activation in the cerebral cortex of newborn piglets

  2. Expression of mutant alpha1 Na/K-ATPase (show ATP1A1 Proteins) defective in conformational transition attenuates Src-mediated signal transduction

  3. 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.

SRC Protein Profile

Protein Summary

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.

Alternative names and synonyms associated with SRC

  • v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) (SRC)
  • proto-oncogene tyrosine-protein kinase src (AaeL_AAEL002471)
  • proto-oncogene tyrosine-protein kinase src (CpipJ_CPIJ010659)
  • Rous sarcoma oncogene (Src)
  • Src oncogene at 64B (Src64B)
  • v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (SRC)
  • v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (Src)
  • v-src sarcoma viral oncogene (SRC)
  • ASV protein
  • AW259666 protein
  • c-Src protein
  • C-src1 protein
  • CG7524 protein
  • D-src protein
  • D-Src64B protein
  • Dmel\CG7524 protein
  • DmHD-358 protein
  • Dm SRC1 protein
  • dsrc protein
  • Dsrc64 protein
  • Dsrc64B protein
  • HD-358 protein
  • MRE5 protein
  • p60-Src protein
  • PP60C-SCR protein
  • pp60c-src protein
  • SDR protein
  • src protein
  • SRC1 protein
  • src64 protein
  • SRC 64B protein
  • src64b protein

Protein level used designations for SRC

proto-oncogene tyrosine-protein kinase SRC , proto-oncogene tyrosine-protein kinase src , neuronal proto-oncogene tyrosine-protein kinase Src , p60-Src , proto-oncogene c-Src , CG7524-PB , CG7524-PC , CG7524-PD , CG7524-PE , CG7524-PF , CG7524-PG , CG7524-PH , CG7524-PI , CG7524-PJ , Src proto oncogene sequence , Src64B-PB , Src64B-PC , Src64B-PD , Src64B-PE , Src64B-PF , Src64B-PG , Src64B-PH , Src64B-PI , Src64B-PJ , mRNA-like ncRNA in embryogenesis 5 , proto-oncogene tyrosine-protein kinase Src , protooncogene SRC, Rous sarcoma , tyrosine kinase pp60c-src , tyrosine-protein kinase SRC-1 , Rous sarcoma oncogene , c-Src , pp60c-src , tyrosine protein kinase c-src , tyrosine protein kinase pp60-c-src , v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog , src oncogene , v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog , non-tyrosine protein kinase

458229 Pan troglodytes
5574802 Aedes aegypti
6043642 Culex quinquefasciatus
20779 Mus musculus
48973 Drosophila melanogaster
6714 Homo sapiens
83805 Rattus norvegicus
485864 Canis lupus familiaris
535742 Bos taurus
100154503 Sus scrofa
396442 Gallus gallus
Selected quality suppliers for SRC Proteins (SRC)
Did you look for something else?