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The TBK1 (show TBK1 Proteins) Y179A mutant failed to rescue type I IFN production by virally infected RAW264.7 macrophages deficient in TBK1 (show TBK1 Proteins).
identified both Syk (show SYK Proteins) and Src signaling pathways as ones that participate in Borrelia burgdorferi phagocytosis and the resulting cytokine activation.
results indicate that SRC likely plays a central role in regulating multiple unique signaling pathways activated by MTB (show NCAPG2 Proteins) infection
c-Src tyrosine kinase (show CSK Proteins) mediates high glucose-induced endothelin-1 (show EDN1 Proteins) expression
PTPN2 (show PTPN2 Proteins) is a positive regulator of lipopolysaccharide-induced inflammatory response by enhancing the activity of Src through targeting the inhibitory phosphor-tyrosine527 of Src.
demonstrated that both IL-10 (show IL10 Proteins) and TGF-beta (show TGFB1 Proteins) upregulated TIM-3 (show HAVCR2 Proteins) surface expression on dendritic cells via a common signaling pathway that involved sequential activation of c-Src and Bruton's tyrosine kinase (show BTK Proteins)
Results suggest that interleukin-6 (IL-6 (show IL6 Proteins)) increases VEGF-C (show VEGFC Proteins) induction and lymphangiogenesis may involve, at least in part, Src-FAK (show PTK2 Proteins)-STAT3 (show STAT3 Proteins) cascade in lymphatic endothelial cells (LECs).
Transcriptional signature induced by a metastasis-promoting c-Src mutant in a human breast cell line has been reported.
Data show that the essential oil (EO) decreased focal adhesion and invadopodia formation which was accompanied by a drastic downregulation of focal adhesion kinase (FAK) and proto-oncogene protein Src.
miR (show MLXIP Proteins)-222-3p serves as an inhibitor of osteoclastogenesis and c-Src mediates its inhibition of cathepsin K (show CTSK Proteins) and TRAP.
Src64 controls actin dynamics to mediate proper ring canal formation during incomplete cytokinesis during germline cyst development in vivo
that Brat represses the translation of src64B, an upstream regulator of a conserved Rho-dependent pathway previously shown to promote axon retraction
Results show that Src42a and Src64b are required for the normal division capacity of Drosophila intestinal progenitor cells, and that these genes as well as Ack cause progenitor overproliferation in the intestine via core cell cycle activation.
a novel essential role for Src in intestinal stem/progenitor cell proliferation and tumourigenesis initiation in vivo.
Data show that the actin-Capping Protein (show TMOD4 Proteins) (CP) alphabeta heterodimer, which regulates actin (show ACTB Proteins) filament (F-actin (show ACTB Proteins)) polymerization, limits Src-induced apoptosis or tissue overgrowth by restricting JNK (show MAPK8 Proteins) activation.
Dumbfounded/Neph1 (show NEPH1 Proteins), a key diaphragm constituent, is a target of the Src kinase (show CSK Proteins) Src64B. Loss of Src64B activity leads to a reduction in the number of diaphragms, and this effect is in part mediated by loss of Dumbfounded/Neph1 (show NEPH1 Proteins) tyrosine phosphorylation.
Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B in the developing embryonic central nervous system.
E4orf4 has a role in inducing PP2A (show PPP2R2B Proteins)- and Src-dependent cell death while inhibiting classic apoptosis pathways in Drosophila melanogaster
Mutations in a Drosophila src gene, src64, that alter the three HRD amino acids, were identified.
Src64B overexpression induced the formation of specialized haemocytes (lamellocytes), but had no effect on circulating plasmatocyte concentration. Src64B overexpression induced F-actin (show ACTB Proteins) formation and Jun kinase (show MAPK9 Proteins) activation in plasmatocytes.
Data show that the solubilising factor UNC119 (show UNC119 Proteins) sequesters myristoylated Src family protein tyrosine kinases (SFKs) to maintain its enrichment at the plasma membrane to enable signal transduction.
Data indicate a role for AXL receptor tyrosine kinase (AXL (show AXL Proteins)) in regulating the nuclear translocation of epidermal growth factor receptor (EGFR (show EGFR Proteins)) and suggest that AXL (show AXL Proteins)-mediated SRC family kinases (SFKs) and neuregulin-1 (NRG1 (show NRG1 Proteins)) expression promote this process.
High Src expression is associated with breast cancer.
demonstrate for the first time exosomal enrichment of G-protein-coupled receptor kinase (GRK) 5 (show GRK5 Proteins) and GRK6 (show GRK6 Proteins), both of which regulate Src and IGF-IR signaling and have been implicated in cancer.
Src knockdown in Cal27 cells which led to a reduction in pSrc(Y418), as well as treatment with the pSrc(Y418) inhibitors dasatinib and PP2, conferred resistance to 4 anticancer drugs, indicating that the loss of pSrc(Y418) is responsible for the observed effect.
High SRC expression is associated with ovarian cancer.
RanBP9/TSSC3 (show PHLDA2 Proteins) complex cooperatively suppress metastasis via downregulation of Src-dependent Akt (show AKT1 Proteins) pathway to expedite mitochondrial-associated anoikis.
In addition, EB1 (show MAPRE2 Proteins) phosphorylation at Y247 by Src enhances the rate of microtubule catastrophe and significantly stimulates cell migration. These findings thus demonstrate that the Src-EB1 (show MAPRE2 Proteins) axis plays a crucial role in regulating the crosstalk between microtubules and focal adhesions to promote cell migration.
Results indicate Src homology 3 (SH3) domain-binding glutamic acid-rich-like protein (SH3BGRL) in driving tumor metastasis through c-Src activation, and suggests that hSH3BGRL mutation status could be relevant to cancer diagnosis and therapy.
RhoA (show RHOA Proteins) and membrane fluidity mediates the spatially polarized Src/FAK (show PTK2 Proteins) activation in response to shear stress.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
The Src gene possibly contributed to conducting association analysis and can be recognized as genetic marker in milk production traits and other performance for animal breeding and genetics.
src has a role in activation of 5'-AMP (show TMPRSS5 Proteins)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells
results indicate that integrin engagement disrupts VE-cadherin-containing adherens junctions via the activation of Src, but not Ras, possibly as a result of modulation of the actin network
These results suggest that TGF-beta1 (show TGFB1 Proteins)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK (show PTK2 Proteins)/Src-dependent and -independent pathways.
The findings are consistent with previous studies that indicate a link between Na,K-ATPase (show ATP1A1 Proteins) activity and SFK signaling.
Src kinase (show CSK Proteins) mediates hypoxia-induced caspase-1 (show CASP1 Proteins) activation in the cerebral cortex of newborn piglets
Expression of mutant alpha1 Na/K-ATPase (show ATP1A1 Proteins) defective in conformational transition attenuates Src-mediated signal transduction
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
proto-oncogene tyrosine-protein kinase SRC
, proto-oncogene tyrosine-protein kinase src
, neuronal proto-oncogene tyrosine-protein kinase Src
, proto-oncogene c-Src
, Src proto oncogene sequence
, mRNA-like ncRNA in embryogenesis 5
, proto-oncogene tyrosine-protein kinase Src
, protooncogene SRC, Rous sarcoma
, tyrosine kinase pp60c-src
, tyrosine-protein kinase SRC-1
, Rous sarcoma oncogene
, tyrosine protein kinase c-src
, tyrosine protein kinase pp60-c-src
, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
, src oncogene
, v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
, non-tyrosine protein kinase