anti-Human STAT1 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended STAT1 Antibody (supplied by: Log in to see )

Antigen
Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Antibodies
  • IMUP
  • H2RSP
  • IMUP-1
  • IMUP-2
  • 2010005J02Rik
  • AA408197
  • DD6G4-4
  • CANDF7
  • ISGF-3
  • STAT91
  • STAT4
  • XStat1
  • STAT
  • STAT1
  • dZ182H3.3
  • si:by134g18.2
  • si:by51f19.1
  • si:dz182h3.3
  • si:dz199m19.1
  • si:dz73o4.2
  • signal transducer and activator of transcription 1, 91kDa
  • RIKEN cDNA 2200002D01 gene
  • signal transducer and activator of transcription 1
  • signal transducer and activator of transcription 4
  • STAT1
  • 2200002D01Rik
  • Stat1
  • stat1
  • stat4
Reactivity
Human, Mouse (Murine), Rat (Rattus)
617
298
243
43
27
26
26
23
18
15
14
11
9
5
4
4
3
3
2
2
2
1
1
Host
Rabbit
396
209
20
15
3
3
1
Clonality
Polyclonal
Conjugate
This STAT1 antibody is un-conjugated
18
18
15
14
14
14
7
7
6
6
6
6
5
5
5
5
5
5
5
5
5
5
5
4
4
4
4
4
4
2
2
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
539
186
162
111
104
56
51
31
24
14
10
5
5
4
2
2
1
1
1
Options
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Catalog No. ABIN674889
$ 307.45
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
11.571528 ABIN239822 IHC (p) IP WB Mouse IgG2b Log in to see SM1
11.571528 ABIN732623 IF (p) IHC (p) WB Rabbit IgG pTyr701 Log in to see Polyclonal 1
11.571528 ABIN214518 ICC IHC (p) IP WB Rabbit C-Term Log in to see Polyclonal
11.571528 ABIN5611535 EIA IHC (p) WB Rabbit IgG C-Term Log in to see Polyclonal
11.571528 ABIN5611519 EIA IHC (p) WB Rabbit IgG pSer727 Log in to see Polyclonal
11.571528 ABIN498804 IHC (p) WB Rabbit pSer727 Log in to see Polyclonal
11.571528 ABIN498895 IHC (p) WB Rabbit Log in to see Polyclonal
11.571528 ABIN1109148 IHC (p) WB Rabbit IgG C-Term Log in to see Polyclonal
11.571528 ABIN5011052 IF (p) IHC (p) Mouse IgG AA 680-715 Log in to see 7G8
1 ABIN3043938 IHC (p) WB Rabbit IgG AA 114-143, N-Term Log in to see Polyclonal
1 ABIN269146 IHC (p) IP IHC WB Mouse IgG2b AA 721-733 Log in to see SM1 2
1 ABIN358231 EIA IHC (p) WB Rabbit Ig pSer727 Log in to see Polyclonal 5
1 ABIN196688 IHC (p) WB Rabbit pTyr701 Log in to see Polyclonal 4
1 ABIN196892 IF IHC (p) WB Rabbit pSer727 Log in to see Polyclonal 4
1 ABIN197392 IHC (p) WB Rabbit Ser727 Log in to see Polyclonal 4
1 ABIN197172 IHC (p) WB Rabbit Tyr701 Log in to see Polyclonal 6
1 ABIN94471 IHC (p) IP WB Mouse IgG2b AA 721-733 Log in to see SM1 5
1 ABIN5518871 IHC (p) WB Rabbit IgG AA 2-230 Log in to see Polyclonal
1 ABIN746168 IF (p) IHC (p) WB Rabbit IgG AA 700-750, pSer727 Log in to see Polyclonal
1 ABIN389662 IHC (p) WB Rabbit Ig pSer727 Log in to see Polyclonal

General

Antigen Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(617), (298), (243), (43), (27), (26), (26), (23), (18), (15), (14), (11), (9), (5), (4), (4), (3), (3), (2), (2), (2), (1), (1)
Host Rabbit
(396), (209), (20), (15), (3), (3), (1)
Clonality
Polyclonal
Conjugate This STAT1 antibody is un-conjugated
(18), (18), (15), (14), (14), (14), (7), (7), (6), (6), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (2), (2), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(539), (186), (162), (111), (104), (56), (51), (31), (24), (14), (10), (5), (5), (4), (2), (2), (1), (1), (1)
Pubmed 3 references available
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Product Details anti-STAT1 Antibody

Target Details STAT1 Application Details Handling References for anti-STAT1 antibody (ABIN674889) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human STAT1
Isotype IgG

Target Details STAT1

Product Details anti-STAT1 Antibody Application Details Handling References for anti-STAT1 antibody (ABIN674889) Images back to top
Antigen
Alternative Name Stat1 (STAT1 Antibody Abstract)
Background

Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.

Subcellular location: Cytoplasm, Nucleus

Synonyms: CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, Signal transducer and activator of transcription 1-alpha/beta, Transcription factor ISGF-3 components p91/p84, STAT1

Gene ID 6772
UniProt P42224
Research Area Cancer, Transcription Factors, Signaling, Receptors, Inflammation
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events

Application Details

Product Details anti-STAT1 Antibody Target Details STAT1 Handling References for anti-STAT1 antibody (ABIN674889) Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-STAT1 Antibody Target Details STAT1 Application Details References for anti-STAT1 antibody (ABIN674889) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-STAT1 antibody (ABIN674889)

Product Details anti-STAT1 Antibody Target Details STAT1 Application Details Handling Images back to top
Product cited in:

Chen, Ding, Li, Huang, Li, Yang, Zhang, Pan, Huang, Meng, Li: "Hesperetin derivative-14 alleviates inflammation by activating PPAR-γ in mice with CCl4-induced acute liver injury and LPS-treated RAW264.7 cells." in: Toxicology letters, Vol. 274, pp. 51-63, 2017 Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)).

Zhou, Lu, Wang, Xiao, Liu, Xing: "microRNA let-7c is essential for the anisomycin-elicited apoptosis in Jurkat T cells by linking JNK1/2 to AP-1/STAT1/STAT3 signaling." in: Scientific reports, Vol. 6, pp. 24434, 2016

Wang, Wang, Song, Chu, Qu: "Deficiency of interferon-gamma or its receptor promotes colorectal cancer development." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 35, Issue 4, pp. 273-80, 2015

Images

Product Details anti-STAT1 Antibody Target Details STAT1 Application Details Handling References for anti-STAT1 antibody (ABIN674889) back to top
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) antibody (ABIN674889) Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-STAT1 Polyclo...