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|Application / Reactivity||Human||Mouse (Murine)||Rat (Rattus)|
|Western Blotting (WB)||467 Antibodies||185 Antibodies||133 Antibodies|
|Proximity Ligation Assay (PLA)||1 Antibodies|
|Intracellular Staining (ICS)||18 Antibodies||14 Antibodies||4 Antibodies|
|Immunoprecipitation (IP)||94 Antibodies||45 Antibodies||34 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||87 Antibodies||55 Antibodies||28 Antibodies|
|Immunohistochemistry (IHC)||160 Antibodies||88 Antibodies||78 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Antigen||Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This STAT1 antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-STAT1 AntibodyTarget Details STAT1 Application Details Handling Images
|Specificity||This antibody detects endogenous levels of p-STAT1 protein only when phosphorylated at Ser727.|
Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
|Purity||> 95 % by SDS-PAGE|
Target Details STAT1Product Details anti-STAT1 Antibody Application Details Handling Images back to top
|Alternative Name||STAT1 (STAT1 Antibody Abstract)|
|Background||TAT1 is known to associate with the transcription factors p48, Sp1, and p300. STAT1 is activated by peptide hormones, growth factors and cytokines, particularly cytokines of the interferon family. STAT1 alpha and STAT1 beta isoforms arise by alternative splicing of a single gene. The only difference between the two proteins is that STAT1 beta lacks 38 carboxy terminal amino acids. Contained within these 38 terminal amino acids of STAT1 alpha is a critical serine residue (Ser 727) whose phosphorylation is required for maximal transcription activity induced by IFN gamma.Synonyms: Signal transducer and activator of transcription 1-alpha/beta, Transcription factor ISGF-3 components p91/p84|
|Molecular Weight||approx. 87 kDa|
|Research Area||Cancer, Transcription Factors, Signaling, Receptors, Inflammation|
|Pathways||JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway|
Application DetailsProduct Details anti-STAT1 Antibody Target Details STAT1 Handling Images back to top
Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-STAT1 Antibody Target Details STAT1 Application Details Images back to top
|Buffer||Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
ImagesProduct Details anti-STAT1 Antibody Target Details STAT1 Application Details Handling back to top