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anti-Mouse (Murine) STAT2 Antibodies:
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Human Monoclonal STAT2 Primary Antibody for IF, IP - ABIN967806
Blesofsky, Mowen, Arduini, Baker, Murphy, Bowtell, David: Regulation of STAT protein synthesis by c-Cbl. in Oncogene 2001
Show all 5 references for ABIN967806
Human Polyclonal STAT2 Primary Antibody for WB - ABIN871439
Yan, Qureshi, Zhong, Wen, Darnell: The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2. in Nucleic acids research 1995
Show all 4 references for ABIN871439
Human Polyclonal STAT2 Primary Antibody for IHC (p), WB - ABIN319409
Schamel, Reth: Monomeric and oligomeric complexes of the B cell antigen receptor. in Immunity 2000
Show all 4 references for ABIN319409
Human Polyclonal STAT2 Primary Antibody for EIA, IHC (p) - ABIN357081
Rodriguez, Wang, Horvath: Hendra virus V protein inhibits interferon signaling by preventing STAT1 and STAT2 nuclear accumulation. in Journal of virology 2003
Show all 2 references for ABIN357081
Human Monoclonal STAT2 Primary Antibody for WB - ABIN967579
Bromberg, Darnell: The role of STATs in transcriptional control and their impact on cellular function. in Oncogene 2000
Show all 2 references for ABIN967579
Human Polyclonal STAT2 Primary Antibody for EIA, WB - ABIN401444
Li, Leung, Kerr, Stark: Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. in Molecular and cellular biology 1997
Human Polyclonal STAT2 Primary Antibody for WB - ABIN223186
Dolniak, Katsoulidis, Carayol, Altman, Redig, Tallman, Ueda, Watanabe-Fukunaga, Fukunaga, Platanias: Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2. in The Journal of biological chemistry 2008
The full length cDNA sequence of Atlantic salmon (Salmo salar) ssSTAT2 was determined and phylogenetic analysis of the amino acid sequence grouped this novel salmon gene to the STAT2 clade.
transcriptional activation of Adar1 (show ADAR Antibodies) by IFN occurs in the absence of STAT1 (show STAT1 Antibodies) by a non-canonical STAT2-dependent pathway in mouse but not human cells.
IFN-alpha (show IFNA Antibodies)/beta is able to drive the formation of a Stat2 and IRF-9 (show IRF9 Antibodies) complex that drives the expression of a subset of IFN-stimulated genes, but with substantially delayed kinetics.
Activation of STAT2/IRF9 (show IRF9 Antibodies) induces a prolonged ISGF3 (show IRF9 Antibodies)-like transcriptome and generates an antiviral response.
In a mouse syngeneic tumor transplantation model STAT2 expression reduces tumor growth.
Data suggest a role for Vc in Nanog regulation networks and reveal a novel role for STAT2 in regulating Nanog expression.
Stat2 loss leads to reduced expression of NF-kappaB (show NFKB1 Antibodies) target genes by affecting nuclear translocation of NF-kappaB (show NFKB1 Antibodies).
STAT1 (show STAT1 Antibodies), not STAT2 or IRF9 (show IRF9 Antibodies), prevent the emergence of a lethal antiviral CD4 (show CD4 Antibodies)(+) T-cell response after lymphocytic choriomeningitis virus infection.
Activation of Oas1a gene expression by type I IFN requires both STAT1 (show STAT1 Antibodies) and STAT2.
In a constructive process, pM27 recruits DDB1 (show DDB1 Antibodies) to exploit ubiquitin ligase (show RNF123 Antibodies) complexes catalyzing the obstruction of the STAT2-dependent antiviral state of cells to permit viral replication.
NS5 (show RAF1 Antibodies) is able to bind and degrade human STAT2, but not mouse STAT2; demonstrate that mouse STAT2 restricts early dengue virus replication in vivo
These results suggest that STAT6 (show STAT6 Antibodies) plays an important role in regulating Sp1 (show PSG1 Antibodies) and BCL6 (show BCL6 Antibodies) through STAT2 to exert the anti-proliferative effects of type I IFN.
Interferonstimulated gene factor 3 complex, which consists of STAT1 (show STAT1 Antibodies), STAT2 and IRF9 (show IRF9 Antibodies), is required for the induction of SAMHD1 (show SAMHD1 Antibodies) expression by IFN-alpha (show IFNA Antibodies) in SMMC-7721 cells.
IFN-beta (show IFNB1 Antibodies) exhibited significant cytotoxicity in HepG2 cells mainly through phosphorylation of STAT2.
STAT2 rs2066807 polymorphism is not associated with cervical cancer.
Influenza virus-infected cells respond with increased induction of interferon beta (show IFNB1 Antibodies) upon Staphylococcus aureus super-infection, however, subsequent interferon (show IFNA Antibodies)-stimulated gene expression are rather impaired due to a block of STAT1 (show STAT1 Antibodies)-STAT2 dimerization.
The results demonstrated that Peste-des (show DES Antibodies)-petits-ruminants virus V protein blocks interferon (show IFNA Antibodies) actions in a dose dependent manner and restrains the translocation of STAT1 (show STAT1 Antibodies)/2 proteins.
Respiratory syncytial virus NS1 (show PTPN11 Antibodies) upregulates SOCS1 (show SOCS1 Antibodies) expression in a RIG-I (show DDX58 Antibodies)- and TLR3 (show TLR3 Antibodies)-independent pathway, to inhibit STAT2 phosphorylation.
These findings demonstrate that rotavirus probably employs a novel strategy to inhibit interferon (show IFNA Antibodies)-induced STAT (show STAT1 Antibodies) signalling, which acts after STAT1 (show STAT1 Antibodies)/STAT2 activation and binding to importin-alpha (show KPNA4 Antibodies).
Data indicate that the RVB1 (show RUVBL1 Antibodies)/2 chromatin-remodeling complex is required for efficient Pol II recruitment and initiation at IFN-alpha (show IFNA Antibodies)-stimulated genes (ISGs) promoters and is recruited through interaction with the STAT2 transactivation domain.
Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1 (show STAT1 Antibodies)/STAT2 nuclear translocation.
Nsp1beta inhibits interferon-activated (show MNDA Antibodies) STAT1 (show STAT1 Antibodies)/STAT2 signal transduction by inducing karyopherin-alpha1 degradation.
the majority of the STAT1 (show STAT1 Antibodies)/STAT2/IRF9 (show IRF9 Antibodies) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked
Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 (show STAT1 Antibodies) and, to a lesser extent, STAT2.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.
, signal transducer and activator of transcription 2
, signal transducer and activator of transcription (AGAP000099-PA)
, interferon alpha induced transcriptional activator