Browse our anti-STAT2 (STAT2) Antibodies

Full name:
anti-Signal Transducer and Activator of Transcription 2, 113kDa Antibodies (STAT2)
On www.antibodies-online.com are 275 Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Antibodies from 35 different suppliers available. Additionally we are shipping STAT2 Kits (37) and STAT2 Proteins (10) and many more products for this protein. A total of 332 STAT2 products are currently listed.
Synonyms:
1600010G07Rik, AW496480, ISGF-3, P113, stat2, STAT113, wu:fj84d07
list all antibodies Gene Name GeneID UniProt
STAT2 20847  
STAT2 288774  
STAT2 6773 P52630

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Most Popular Reactivities for anti-STAT2 (STAT2) Antibodies

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anti-Mouse (Murine) STAT2 Antibodies:

anti-Rat (Rattus) STAT2 Antibodies:

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Top referenced anti-STAT2 Antibodies

  1. Human Monoclonal STAT2 Primary Antibody for IF, IP - ABIN967806 : Blesofsky, Mowen, Arduini, Baker, Murphy, Bowtell, David: Regulation of STAT protein synthesis by c-Cbl. in Oncogene 2001 (PubMed)
    Show all 5 references for 967806

  2. Human Polyclonal STAT2 Primary Antibody for IHC (p), WB - ABIN319409 : Schamel, Reth: Monomeric and oligomeric complexes of the B cell antigen receptor. in Immunity 2000 (PubMed)
    Show all 4 references for 319409

  3. Human Monoclonal STAT2 Primary Antibody for WB - ABIN967579 : Bromberg, Darnell: The role of STATs in transcriptional control and their impact on cellular function. in Oncogene 2000 (PubMed)
    Show all 2 references for 967579

  4. Human Polyclonal STAT2 Primary Antibody for EIA, IHC (p) - ABIN357081 : Rodriguez, Wang, Horvath: Hendra virus V protein inhibits interferon signaling by preventing STAT1 and STAT2 nuclear accumulation. in Journal of virology 2003 (PubMed)
    Show all 2 references for 357081

  5. Human Polyclonal STAT2 Primary Antibody for FACS - ABIN4898096 : Thacker, Berthier, Mattinzoli, Rastaldi, Kretzler, Kaplan: The detrimental effects of IFN-α on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)

More Antibodies against STAT2 Interaction Partners

Atlantic Salmon (Salmo salar) Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) interaction partners

  1. The full length cDNA sequence of Atlantic salmon (Salmo salar) ssSTAT2 was determined and phylogenetic analysis of the amino acid sequence grouped this novel salmon gene to the STAT2 clade.

Mouse (Murine) Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) interaction partners

  1. this study shows that STAT2 plays a critical role in TLR-induced dendritic cell activation and cross-presentation, and

  2. this study shows that STAT2 plays a critical role in TLR-induced dendritic cell activation and cross-presentation

  3. these studies identify phosphorylation of S734-STAT2 as a new regulatory mechanism that negatively controls the type I IFN-antiviral response.

  4. IFN-I can mediate ISG expression inmixed glial cell cultures (MGCs) via ISGF3 (show IRF9 Antibodies)-independent signaling pathways but with reduced efficiency, with delayed and prolonged kinetics, and is more dependent on STAT1 (show STAT1 Antibodies) and STAT2 than IRF9 (show IRF9 Antibodies); and 2) signaling pathways not involving STAT1 (show STAT1 Antibodies), STAT2, or IRF9 (show IRF9 Antibodies) play a minor role only in mediating IFN-alpha (show IFNA Antibodies)-stimulated genes expression in MGCs.

  5. transcriptional activation of Adar1 (show ADAR Antibodies) by IFN occurs in the absence of STAT1 (show STAT1 Antibodies) by a non-canonical STAT2-dependent pathway in mouse but not human cells.

  6. IFN-alpha (show IFNA Antibodies)/beta is able to drive the formation of a Stat2 and IRF-9 (show IRF9 Antibodies) complex that drives the expression of a subset of IFN-stimulated genes, but with substantially delayed kinetics.

  7. Activation of STAT2/IRF9 (show IRF9 Antibodies) induces a prolonged ISGF3 (show IRF9 Antibodies)-like transcriptome and generates an antiviral response.

  8. In a mouse syngeneic tumor transplantation model STAT2 expression reduces tumor growth.

  9. Data suggest a role for Vc in Nanog regulation networks and reveal a novel role for STAT2 in regulating Nanog expression.

  10. Stat2 loss leads to reduced expression of NF-kappaB (show NFKB1 Antibodies) target genes by affecting nuclear translocation of NF-kappaB (show NFKB1 Antibodies).

Human Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) interaction partners

  1. data suggest that STAT2 plays a role in the psoriasis pathogenesis by regulating the expression of CXCL11 (show CXCL11 Antibodies) and CCL5 (show CCL5 Antibodies), and thereby attracting IFNgamma-producing immune cells to the skin

  2. Interferon-alpha-enhanced IL-10 expression in human CD4 T cells is regulated by STAT3, STAT2, and BATF transcription factors.

  3. the rate-limiting transition state for binding between the TAZ1 (show TAZ Antibodies) domain of CREB binding protein (show CREBBP Antibodies) and the intrinsically disordered transactivation domain of STAT2 (TAD (show CRTAM Antibodies)-STAT2) by site-directed mutagenesis and kinetic experiments (Phi-value analysis) and found that the native protein-protein binding interface is not formed at the transition state for binding.

  4. these studies identify phosphorylation of S734-STAT2 as a new regulatory mechanism that negatively controls the type I IFN-antiviral response.

  5. Data show that moringin (GMG-ITC) had a limited inhibitory effect on IFNalpha-induced STAT1 (show STAT1 Antibodies) and STAT2 activity, indicating differentially targeting JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) signaling pathways.

  6. study demonstrates that overexpression of Porcine deltacoronavirus (PDCoV) nsp5 (show SPECC1 Antibodies) also antagonizes IFN signaling by cleaving STAT2, an essential component of transcription factor complex ISGF3 (show STAT1 Antibodies), and that PDCoV infection reduces the levels of STAT2, which may affect the innate immune response

  7. PKV VP3 associated with STAT2 and IRF9 (show IRF9 Antibodies), and interfered with the formation of the STAT2-IRF9 (show IRF9 Antibodies) and STAT2-STAT2 complex.

  8. The authors have discovered a novel phosphorylation of STAT2 on T387 that negatively regulates signal from the type I interferon receptor (show IFNAR1 Antibodies) to the genome by transcription factor ISGF3 (show STAT1 Antibodies).

  9. STAT2 recruits USP18 (show USP18 Antibodies) to the type I IFN receptor subunit IFNAR2 (show IFNAR2 Antibodies) via its constitutive membrane-distal STAT2-binding site.

  10. These results establish that activation of STAT (show STAT1 Antibodies) pathway is essential for anti-hepatitis c virus efficacy of IFN-alpha (show IFNA Antibodies).

Pig (Porcine) Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) interaction partners

  1. While La Piedad Michoacan Mexico Virus V protein does not affect the protein levels of STAT1 (show STAT1 Antibodies) or STAT2, it does prevent the interferon (show IFNA Antibodies)-induced phosphorylation and nuclear translocation of STAT1 (show STAT1 Antibodies) and STAT2 thereby inhibiting cellular responses to interferon alpha (show IFNA Antibodies)/beta.

  2. Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1 (show STAT1 Antibodies)/STAT2 nuclear translocation.

  3. Nsp1beta inhibits interferon-activated (show MNDA Antibodies) STAT1 (show STAT1 Antibodies)/STAT2 signal transduction by inducing karyopherin-alpha1 degradation.

  4. the majority of the STAT1 (show STAT1 Antibodies)/STAT2/IRF9 (show IRF9 Antibodies) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked

Cow (Bovine) Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) interaction partners

  1. Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 (show STAT1 Antibodies) and, to a lesser extent, STAT2.

STAT2 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with STAT2

  • signal transducer and activator of transcription 2 (stat2) antibody
  • signal transducer and activator of transcription 2, 113kDa (STAT2) antibody
  • signal transducer and activator of transcription (AGAP000099-PA) (STAT2) antibody
  • signal transducer and activator of transcription 2 (Stat2) antibody
  • signal transducer and activator of transcription 2 (LOC100344467) antibody
  • signal transducer and activator of transcription 2-like (LOC100858732) antibody
  • signal transducer and activator of transcription 2, 113kDa (Stat2) antibody
  • 1600010G07Rik antibody
  • AW496480 antibody
  • ISGF-3 antibody
  • P113 antibody
  • stat2 antibody
  • STAT113 antibody
  • wu:fj84d07 antibody

Protein level used designations for STAT2

fj84d07 , signal transducer and activator of transcription 2 , signal transducer and activator of transcription (AGAP000099-PA) , interferon alpha induced transcriptional activator

GENE ID SPECIES
565200 Danio rerio
712694 Macaca mulatta
1272172 Anopheles gambiae str. PEST
100270812 Salmo salar
20847 Mus musculus
288774 Rattus norvegicus
100344467 Oryctolagus cuniculus
100858732 Gallus gallus
6773 Homo sapiens
481111 Canis lupus familiaris
100719719 Cavia porcellus
396923 Sus scrofa
451996 Pan troglodytes
511023 Bos taurus
101108211 Ovis aries
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