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anti-Chimpanzee STAT2 antibody for ELISA

Recommended STAT2 Antibody (supplied by: Log in to see )

Antigen
Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Antibodies
  • 1600010G07Rik
  • AW496480
  • ISGF-3
  • P113
  • p113
  • stat2
  • STAT113
  • wu:fj84d07
Epitope
pTyr690, Internal Region
43
43
23
17
15
14
13
13
11
9
8
5
5
4
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Chimpanzee, Macaque, Vervet Monkey (Chlorocebus pygerythrus), Rat (Rattus), Dog (Canine), Pig (Porcine), Horse (Equine), Mouse (Murine), Cow (Bovine)
223
79
56
4
2
2
2
2
2
2
2
Host
Rabbit
233
26
1
Clonality
Polyclonal
Conjugate
This STAT2 antibody is un-conjugated
10
9
8
6
6
6
2
2
2
2
2
2
2
2
2
1
Application
ELISA, Western Blotting (WB)
208
94
93
32
23
22
8
4
4
4
3
3
1
1
1
1
Supplier
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Catalog No. ABIN964892
$ 135.00
Plus shipping costs $45.00 and $21.00 dry ice
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0012092679 ABIN2505982 ELISA WB Rabbit IgG N-Term, pTyr690 Log in to see Polyclonal
0.0012092679 ABIN2505981 ELISA WB Rabbit N-Term Log in to see Polyclonal

Similar anti-STAT2 Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus) Chimpanzee Macaque Vervet Monkey (Chlorocebus pygerythrus) Dog (Canine) Pig (Porcine) Horse (Equine) Cow (Bovine)
Western Blotting (WB) 178 Antibodies 61 Antibodies 41 Antibodies 3 Antibodies 3 Antibodies 3 Antibodies 3 Antibodies 3 Antibodies 3 Antibodies 3 Antibodies
Immunostaining (ISt) 1 Antibodies
Immunoprecipitation (IP) 21 Antibodies 2 Antibodies 1 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 30 Antibodies 10 Antibodies 6 Antibodies
Immunohistochemistry (IHC) 93 Antibodies 27 Antibodies

General

Antigen Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Antibodies
Epitope pTyr690, Internal Region
(43), (43), (23), (17), (15), (14), (13), (13), (11), (9), (8), (5), (5), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Chimpanzee, Macaque, Vervet Monkey (Chlorocebus pygerythrus), Rat (Rattus), Dog (Canine), Pig (Porcine), Horse (Equine), Mouse (Murine), Cow (Bovine)
(223), (79), (56), (4), (2), (2), (2), (2), (2), (2), (2)
Host Rabbit
(233), (26), (1)
Clonality
Polyclonal
Conjugate This STAT2 antibody is un-conjugated
(10), (9), (8), (6), (6), (6), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application ELISA, Western Blotting (WB)
(208), (94), (93), (32), (23), (22), (8), (4), (4), (4), (3), (3), (1), (1), (1), (1)
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Product Details anti-STAT2 Antibody

Target Details STAT2 Application Details Handling Images
Specificity This affinity purified antibody is directed against human STAT2 pY690 protein.  The product was affinity purified from monospecific antiserum by immunoaffinity chromatography.  A BLAST analysis was used to suggest cross-reactivity with STAT2 pY690 protein from human, rat (73%) and mouse (76%), sources based on homology with the immunizing sequence.  Reactivity against homologues from other sources is not known.
Cross-Reactivity Chimpanzee, Macaque, Vervet Monkey (Chlorocebus pygerythrus), Rat (Rattus), Dog (Canine), Pig (Porcine), Horse (Equine), Mouse (Murine), Sheep (Ovine)
Characteristics This antibody is designed, produced, and validated as part of a collaboration with the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. STAT2 is a member of the STAT family of transcription factors. Unlike other STATs, STAT2 is unique as it can only be activated by interferons (IFNs). STAT2 is a critical component in mediating many IFN-stimulated biological activities including antiproliferation and antiviral responses. Upon IFN treatment, STAT1 and STAT2 become tyrosine phosphorylated, assemble as heterodimers that bind IRF9 to form the ISGF3 complex. This complex translocates to the nucleus, binds to promoters of IFN-stimulated genes and mediates gene transcription. Consequently, mutations in STAT2 or loss of STAT2 expression leads to impairment in IFN signal transduction and gene activation. IFN-alpha is an approved drug for the treatment of several forms of cancer. Yet only a subset of patients who receive IFN-alpha therapy benefit from the treatment. Given that STAT2 is activated by IFNs, it is important to define if the reduced or lack of antitumor effects seen in cancer patients on IFN therapy is due to in defects in STAT2 function. Our goal is to identify regions/motifs within the structural domains of STAT2 that not only are essential for the tyrosine phosphorylation of STAT2, but also regulate the antitumor effects of IFN-alpha. Collectively, the results of our studies will emphasize the physiological role of STAT2 in cancer. From a clinical viewpoint, cancer patients who may benefit the most from receiving IFN-alpha therapy can be selected based on their STAT2 function.
Immunogen This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the N-terminus of human STAT2 protein.
Immunogen Type: Peptide
Isotype IgG

Target Details STAT2

Product Details anti-STAT2 Antibody Application Details Handling Images back to top
Antigen
Alternative Name STAT2 (STAT2 Antibody Abstract)
Background This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. STAT2 is a member of the STAT family of transcription factors.  Unlike other STATs, STAT2 is unique as it can only be activated by interferons (IFNs). STAT2 is a critical component in mediating many IFN-stimulated biological activities including antiproliferation and antiviral responses. Upon IFN treatment, STAT1 and STAT2 become tyrosine phosphorylated, assemble as heterodimers that bind IRF9 to form the ISGF3 complex.  This complex translocates to the nucleus, binds to promoters of IFN-stimulated genes and mediates gene transcription.  Consequently, mutations in STAT2 or loss of STAT2 expression leads to impairment in IFN signal transduction and gene activation.  IFN-alpha is an approved drug for the treatment of several forms of cancer. Yet only a subset of patients who receive IFN-alpha therapy benefit from the treatment.  Given that STAT2 is activated by IFNs, it is important to define if the reduced or lack of antitumor effects seen in cancer patients on IFN therapy is due to in defects in STAT2 function. Our goal is to identify regions/motifs within the structural domains of STAT2 that not only are essential for the tyrosine phosphorylation of STAT2, but also regulate the antitumor effects of IFN-alpha.  Collectively, the results of our studies will emphasize the physiological role of STAT2 in cancer.  From a clinical viewpoint, cancer patients who may benefit the most from receiving IFN-alpha therapy can be selected based on their STAT2 function.
Synonyms: interferon alpha induced transcriptional activator antibody, ISGF3 antibody, MGC59816 antibody, P113 antibody, signal transducer and activator of transcription 2 113kD antibody, STAT113 antibody
Gene ID 6773, 4885615
UniProt P52630
Pathways JAK-STAT Signaling

Application Details

Product Details anti-STAT2 Antibody Target Details STAT2 Handling Images back to top
Application Notes This affinity purified antibody has been tested for use in ELISA and western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 113 kDa in size corresponding to STAT2 pY690 protein by western blotting in the appropriate cell lysate or extract.
Comment

Gene Name: STAT2

Restrictions For Research Use only

Handling

Product Details anti-STAT2 Antibody Target Details STAT2 Application Details Images back to top
Format Liquid
Concentration 1.15 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is three (3) months from date of opening.
Expiry Date 3 months

Images

Product Details anti-STAT2 Antibody Target Details STAT2 Application Details Handling back to top
Supplier Images
Western Blotting (WB) image for anti-STAT2 antibody (Signal Transducer and Activator of Transcription 2, 113kDa) (pTyr690) (ABIN964892) Western blot using affinity purified anti-Stat2pY690 antibody shows detection of Stat...