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|Antigen||Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Antibodies|
|Conjugate||This STAT2 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
|2 references available|
|Supplier||Log in to see|
Product Details anti-STAT2 AntibodyTarget Details STAT2 Application Details Handling References for anti-STAT2 antibody (ABIN357081) Images
|Specificity||This antibody detects STAT2 at C-term.|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human STAT2.|
Target Details STAT2Product Details anti-STAT2 Antibody Application Details Handling References for anti-STAT2 antibody (ABIN357081) Images back to top
|Alternative Name||STAT2 (STAT2 Antibody Abstract)|
|Background||STAT2 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.Synonyms: Signal transducer and activator of transcription 2, p113|
|Molecular Weight||97916 Da|
|Gene ID||6773, 9606|
|Research Area||Chromatin and Nuclear Signaling, Transcription Factors, Signaling, Receptors, Inflammation|
|Pathways||JAK-STAT Signaling, Hepatitis C, CXCR4-mediated Signaling Events|
Application DetailsProduct Details anti-STAT2 Antibody Target Details STAT2 Handling References for anti-STAT2 antibody (ABIN357081) Images back to top
ELISA 1 : 1,000. Immunohistochemistry 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-STAT2 Antibody Target Details STAT2 Application Details References for anti-STAT2 antibody (ABIN357081) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.|
References for anti-STAT2 antibody (ABIN357081)Product Details anti-STAT2 Antibody Target Details STAT2 Application Details Handling Images back to top
Rodriguez, Wang, Horvath: "Hendra virus V protein inhibits interferon signaling by preventing STAT1 and STAT2 nuclear accumulation." in: Journal of virology, Vol. 77, Issue 21, pp. 11842-5, 2003
Gotoh, Takeuchi, Komatsu, Yokoo: "The STAT2 activation process is a crucial target of Sendai virus C protein for the blockade of alpha interferon signaling." in: Journal of virology, Vol. 77, Issue 6, pp. 3360-70, 2003
ImagesProduct Details anti-STAT2 Antibody Target Details STAT2 Application Details Handling References for anti-STAT2 antibody (ABIN357081) back to top