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anti-Rat (Rattus) STAT2 antibody for Enzyme Immunoassay

Recommended STAT2 Antibody (supplied by: Log in to see )

Antigen
Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Antibodies
  • wu:fj84d07
  • p113
  • stat2
  • 1600010G07Rik
  • AW496480
  • ISGF-3
  • P113
  • STAT113
  • signal transducer and activator of transcription 2
  • signal transducer and activator of transcription 2, 113kDa
  • signal transducer and activator of transcription (AGAP000099-PA)
  • signal transducer and activator of transcription 2-like
  • stat2
  • STAT2
  • Stat2
  • LOC100344467
  • LOC100858732
Epitope
N-Term, pTyr690
42
40
17
15
15
12
12
10
9
8
8
6
5
5
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
225
82
63
9
3
3
2
2
2
2
1
Host
Rabbit
233
24
1
Clonality
Polyclonal
Conjugate
This STAT2 antibody is un-conjugated
10
9
8
6
6
6
3
2
2
2
2
2
2
2
2
2
2
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
211
92
90
36
27
26
10
9
5
3
3
3
2
1
1
1
1
1
Supplier
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Catalog No. ABIN401443
$ 500.50
Plus shipping costs $45.00

Top referenced anti-STAT2 antibody for Enzyme Immunoassay

Similar anti-STAT2 Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus)
Immunofluorescence (fixed cells) (IF/ICC) 1 Antibodies 1 Antibodies 1 Antibodies
Simple Western (SimWes) 3 Antibodies
Western Blotting (WB) 180 Antibodies 64 Antibodies 45 Antibodies
Immunostaining (ISt) 1 Antibodies
Immunoprecipitation (IP) 23 Antibodies 4 Antibodies 3 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 35 Antibodies 10 Antibodies 10 Antibodies
Immunohistochemistry (IHC) 86 Antibodies 30 Antibodies 21 Antibodies

General

Antigen Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Antibodies
Epitope N-Term, pTyr690
(42), (40), (17), (15), (15), (12), (12), (10), (9), (8), (8), (6), (5), (5), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(225), (82), (63), (9), (3), (3), (2), (2), (2), (2), (1)
Host Rabbit
(233), (24), (1)
Clonality
Polyclonal
Conjugate This STAT2 antibody is un-conjugated
(10), (9), (8), (6), (6), (6), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application Enzyme Immunoassay (EIA), Western Blotting (WB)
(211), (92), (90), (36), (27), (26), (10), (9), (5), (3), (3), (3), (2), (1), (1), (1), (1), (1)
Pubmed 1 reference available
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Product Details anti-STAT2 Antibody

Target Details STAT2 Application Details Handling References for anti-STAT2 Antibody (ABIN401443) Images
Specificity This purified antibody is directed against STAT2 pY690 protein.
Cross-Reactivity (Details) Species reactivity (expected):Rat, Mouse.
Species reactivity (tested):Human.
Purification Affinity chromatography
Immunogen Synthetic peptide corresponding to a region near the N-terminus of human STAT2 protein
Isotype IgG

Target Details STAT2

Product Details anti-STAT2 Antibody Application Details Handling References for anti-STAT2 Antibody (ABIN401443) Images back to top
Antigen
Alternative Name STAT2 (STAT2 Antibody Abstract)
Background STAT2 is a member of the STAT family of transcription factors. Unlike other STATs, STAT2 is unique as it can only be activated by interferons (IFNs). STAT2 is a critical component in mediating many IFN-stimulated biological activities including antiproliferation and antiviral responses. Upon IFN treatment, STAT1 and STAT2 become tyrosine phosphorylated, assemble as heterodimers that bind IRF9 to form the ISGF3 complex. This complex translocates to the nucleus, binds to promoters of IFN-stimulated genes and mediates gene transcription. Consequently, mutations in STAT2 or loss of STAT2 expression leads to impairment in IFN signal transduction and gene activation. IFN-alpha is an approved drug for the treatment of several forms of cancer. Yet only a subset of patients who receive IFN-alpha therapy benefit from the treatment. Given that STAT2 is activated by IFNs, it is important to define if the reduced or lack of antitumor effects seen in cancer patients on IFN therapy is due to in defects in STAT2 function. Our goal is to identify regions/motifs within the structural domains of STAT2 that not only are essential for the tyrosine phosphorylation of STAT2, but also regulate the antitumor effects of IFN-alpha. Collectively, the results of our studies will emphasize the physiological role of STAT2 in cancer. From a clinical viewpoint, cancer patients who may benefit the most from receiving IFN-alpha therapy can be selected based on their STAT2 function.Synonyms: Signal transducer and activator of transcription 2, p113
Gene ID 6773
NCBI Accession NP_005410
UniProt P52630
Research Area Chromatin and Nuclear Signaling, Transcription Factors, Signaling, Receptors, Inflammation
Pathways JAK-STAT Signaling, Hepatitis C, CXCR4-mediated Signaling Events

Application Details

Product Details anti-STAT2 Antibody Target Details STAT2 Handling References for anti-STAT2 Antibody (ABIN401443) Images back to top
Application Notes ELISA: 1/85,000. Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-STAT2 Antibody Target Details STAT2 Application Details References for anti-STAT2 Antibody (ABIN401443) Images back to top
Concentration 1.15 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C

References for anti-STAT2 Antibody (ABIN401443)

Product Details anti-STAT2 Antibody Target Details STAT2 Application Details Handling Images back to top
Background publications

Li, Leung, Kerr, Stark: "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling." in: Molecular and cellular biology, Vol. 17, Issue 4, pp. 2048-56, 1997

Images

Product Details anti-STAT2 Antibody Target Details STAT2 Application Details Handling References for anti-STAT2 Antibody (ABIN401443) back to top
Supplier Images
 image for anti-STAT2 antibody (Signal Transducer and Activator of Transcription 2, 113kDa) (N-Term) (ABIN401443) anti-Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) (N-Term), (pTyr690) antibody