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The full length cDNA sequence of Atlantic salmon (Salmo salar) ssSTAT2 was determined and phylogenetic analysis of the amino acid sequence grouped this novel salmon gene to the STAT2 clade.
this study shows that STAT2 plays a critical role in TLR-induced dendritic cell activation and cross-presentation, and
this study shows that STAT2 plays a critical role in TLR-induced dendritic cell activation and cross-presentation
these studies identify phosphorylation of S734-STAT2 as a new regulatory mechanism that negatively controls the type I IFN-antiviral response.
IFN-I can mediate ISG expression inmixed glial cell cultures (MGCs) via ISGF3 (show IRF9 Proteins)-independent signaling pathways but with reduced efficiency, with delayed and prolonged kinetics, and is more dependent on STAT1 (show STAT1 Proteins) and STAT2 than IRF9 (show IRF9 Proteins); and 2) signaling pathways not involving STAT1 (show STAT1 Proteins), STAT2, or IRF9 (show IRF9 Proteins) play a minor role only in mediating IFN-alpha (show IFNA Proteins)-stimulated genes expression in MGCs.
transcriptional activation of Adar1 (show ADAR Proteins) by IFN occurs in the absence of STAT1 (show STAT1 Proteins) by a non-canonical STAT2-dependent pathway in mouse but not human cells.
IFN-alpha (show IFNA Proteins)/beta is able to drive the formation of a Stat2 and IRF-9 (show IRF9 Proteins) complex that drives the expression of a subset of IFN-stimulated genes, but with substantially delayed kinetics.
Activation of STAT2/IRF9 (show IRF9 Proteins) induces a prolonged ISGF3 (show IRF9 Proteins)-like transcriptome and generates an antiviral response.
In a mouse syngeneic tumor transplantation model STAT2 expression reduces tumor growth.
Data suggest a role for Vc in Nanog regulation networks and reveal a novel role for STAT2 in regulating Nanog expression.
Stat2 loss leads to reduced expression of NF-kappaB (show NFKB1 Proteins) target genes by affecting nuclear translocation of NF-kappaB (show NFKB1 Proteins).
Decreased phosphorylated STAT2 expression was accompanied by increased replication of hepatitis C virus and hepatitis E virus.
6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiated the inhibitory effect of IFN-alpha (show IFNA Proteins) on hepatocellular carcinoma cell proliferation through activation of the JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signaling pathway by inhibiting SOCS3 (show SOCS3 Proteins) expression.
data suggest that STAT2 plays a role in the psoriasis pathogenesis by regulating the expression of CXCL11 (show CXCL11 Proteins) and CCL5 (show CCL5 Proteins), and thereby attracting IFNgamma-producing immune cells to the skin
Interferon-alpha-enhanced IL-10 expression in human CD4 T cells is regulated by STAT3, STAT2, and BATF transcription factors.
the rate-limiting transition state for binding between the TAZ1 (show TAZ Proteins) domain of CREB binding protein (show CREBBP Proteins) and the intrinsically disordered transactivation domain of STAT2 (TAD (show CRTAM Proteins)-STAT2) by site-directed mutagenesis and kinetic experiments (Phi-value analysis) and found that the native protein-protein binding interface is not formed at the transition state for binding.
Data show that moringin (GMG-ITC) had a limited inhibitory effect on IFNalpha-induced STAT1 (show STAT1 Proteins) and STAT2 activity, indicating differentially targeting JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signaling pathways.
study demonstrates that overexpression of Porcine deltacoronavirus (PDCoV) nsp5 (show SPECC1 Proteins) also antagonizes IFN signaling by cleaving STAT2, an essential component of transcription factor complex ISGF3 (show STAT1 Proteins), and that PDCoV infection reduces the levels of STAT2, which may affect the innate immune response
PKV VP3 associated with STAT2 and IRF9 (show IRF9 Proteins), and interfered with the formation of the STAT2-IRF9 (show IRF9 Proteins) and STAT2-STAT2 complex.
The authors have discovered a novel phosphorylation of STAT2 on T387 that negatively regulates signal from the type I interferon receptor (show IFNAR1 Proteins) to the genome by transcription factor ISGF3 (show STAT1 Proteins).
While La Piedad Michoacan Mexico Virus V protein does not affect the protein levels of STAT1 (show STAT1 Proteins) or STAT2, it does prevent the interferon (show IFNA Proteins)-induced phosphorylation and nuclear translocation of STAT1 (show STAT1 Proteins) and STAT2 thereby inhibiting cellular responses to interferon alpha (show IFNA Proteins)/beta.
Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1 (show STAT1 Proteins)/STAT2 nuclear translocation.
Nsp1beta inhibits interferon-activated (show MNDA Proteins) STAT1 (show STAT1 Proteins)/STAT2 signal transduction by inducing karyopherin-alpha1 degradation.
the majority of the STAT1 (show STAT1 Proteins)/STAT2/IRF9 (show IRF9 Proteins) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked
Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 (show STAT1 Proteins) and, to a lesser extent, STAT2.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.
, signal transducer and activator of transcription 2
, signal transducer and activator of transcription (AGAP000099-PA)
, interferon alpha induced transcriptional activator