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Browse our STAT2 Proteins (STAT2)

Full name:
Signal Transducer and Activator of Transcription 2, 113kDa Proteins (STAT2)
On www.antibodies-online.com are 9 Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Proteins from 6 different suppliers available. Additionally we are shipping STAT2 Antibodies (255) and STAT2 Kits (44) and many more products for this protein. A total of 318 STAT2 products are currently listed.
Synonyms:
1600010G07Rik, AW496480, ISGF-3, P113, stat2, STAT113, wu:fj84d07
list all proteins Gene Name GeneID UniProt
STAT2 20847  
Rat STAT2 STAT2 288774  
STAT2 6773 P52630

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STAT2 Proteins (STAT2) by Origin

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More Proteins for STAT2 Interaction Partners

Atlantic Salmon (Salmo salar) Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) interaction partners

  1. The full length cDNA sequence of Atlantic salmon (Salmo salar) ssSTAT2 was determined and phylogenetic analysis of the amino acid sequence grouped this novel salmon gene to the STAT2 clade.

Mouse (Murine) Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) interaction partners

  1. transcriptional activation of Adar1 (show ADAR Proteins) by IFN occurs in the absence of STAT1 (show STAT1 Proteins) by a non-canonical STAT2-dependent pathway in mouse but not human cells.

  2. IFN-alpha (show IFNA Proteins)/beta is able to drive the formation of a Stat2 and IRF-9 (show IRF9 Proteins) complex that drives the expression of a subset of IFN-stimulated genes, but with substantially delayed kinetics.

  3. Activation of STAT2/IRF9 (show IRF9 Proteins) induces a prolonged ISGF3 (show IRF9 Proteins)-like transcriptome and generates an antiviral response.

  4. In a mouse syngeneic tumor transplantation model STAT2 expression reduces tumor growth.

  5. Data suggest a role for Vc in Nanog regulation networks and reveal a novel role for STAT2 in regulating Nanog expression.

  6. Stat2 loss leads to reduced expression of NF-kappaB (show NFKB1 Proteins) target genes by affecting nuclear translocation of NF-kappaB (show NFKB1 Proteins).

  7. STAT1 (show STAT1 Proteins), not STAT2 or IRF9 (show IRF9 Proteins), prevent the emergence of a lethal antiviral CD4 (show CD4 Proteins)(+) T-cell response after lymphocytic choriomeningitis virus infection.

  8. Activation of Oas1a gene expression by type I IFN requires both STAT1 (show STAT1 Proteins) and STAT2.

  9. In a constructive process, pM27 recruits DDB1 (show DDB1 Proteins) to exploit ubiquitin ligase (show RNF123 Proteins) complexes catalyzing the obstruction of the STAT2-dependent antiviral state of cells to permit viral replication.

  10. NS5 (show RAF1 Proteins) is able to bind and degrade human STAT2, but not mouse STAT2; demonstrate that mouse STAT2 restricts early dengue virus replication in vivo

Human Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) interaction partners

  1. These findings indicate that overexpression of IFITM1 (show IFITM1 Proteins) enhances the aggressive phenotype of triple-negative SUM149 IBC cells and that this effect is dependent on STAT2/BRG1 (show SMARCA4 Proteins) interaction.

  2. These results suggest that STAT6 (show STAT6 Proteins) plays an important role in regulating Sp1 (show PSG1 Proteins) and BCL6 (show BCL6 Proteins) through STAT2 to exert the anti-proliferative effects of type I IFN.

  3. Interferonstimulated gene factor 3 complex, which consists of STAT1 (show STAT1 Proteins), STAT2 and IRF9 (show IRF9 Proteins), is required for the induction of SAMHD1 (show SAMHD1 Proteins) expression by IFN-alpha (show IFNA Proteins) in SMMC-7721 cells.

  4. IFN-beta (show IFNB1 Proteins) exhibited significant cytotoxicity in HepG2 cells mainly through phosphorylation of STAT2.

  5. transcriptional activation of Adar1 (show ADAR Proteins) by IFN occurs in the absence of STAT1 (show STAT1 Proteins) by a non-canonical STAT2-dependent pathway in mouse but not human cells.

  6. STAT2 rs2066807 polymorphism is not associated with cervical cancer.

  7. Influenza virus-infected cells respond with increased induction of interferon beta (show IFNB1 Proteins) upon Staphylococcus aureus super-infection, however, subsequent interferon (show IFNA Proteins)-stimulated gene expression are rather impaired due to a block of STAT1 (show STAT1 Proteins)-STAT2 dimerization.

  8. The results demonstrated that Peste-des (show DES Proteins)-petits-ruminants virus V protein blocks interferon (show IFNA Proteins) actions in a dose dependent manner and restrains the translocation of STAT1 (show STAT1 Proteins)/2 proteins.

  9. Respiratory syncytial virus NS1 (show PTPN11 Proteins) upregulates SOCS1 (show SOCS1 Proteins) expression in a RIG-I (show DDX58 Proteins)- and TLR3 (show TLR3 Proteins)-independent pathway, to inhibit STAT2 phosphorylation.

  10. These findings demonstrate that rotavirus probably employs a novel strategy to inhibit interferon (show IFNA Proteins)-induced STAT (show STAT1 Proteins) signalling, which acts after STAT1 (show STAT1 Proteins)/STAT2 activation and binding to importin-alpha (show KPNA4 Proteins).

Pig (Porcine) Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) interaction partners

  1. Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1 (show STAT1 Proteins)/STAT2 nuclear translocation.

  2. Nsp1beta inhibits interferon-activated (show MNDA Proteins) STAT1 (show STAT1 Proteins)/STAT2 signal transduction by inducing karyopherin-alpha1 degradation.

  3. the majority of the STAT1 (show STAT1 Proteins)/STAT2/IRF9 (show IRF9 Proteins) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked

Cow (Bovine) Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) interaction partners

  1. Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 (show STAT1 Proteins) and, to a lesser extent, STAT2.

STAT2 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with STAT2

  • signal transducer and activator of transcription 2 (stat2)
  • signal transducer and activator of transcription 2, 113kDa (STAT2)
  • signal transducer and activator of transcription (AGAP000099-PA) (STAT2)
  • signal transducer and activator of transcription 2 (Stat2)
  • signal transducer and activator of transcription 2 (LOC100344467)
  • signal transducer and activator of transcription 2-like (LOC100858732)
  • signal transducer and activator of transcription 2, 113kDa (Stat2)
  • 1600010G07Rik protein
  • AW496480 protein
  • ISGF-3 protein
  • P113 protein
  • stat2 protein
  • STAT113 protein
  • wu:fj84d07 protein

Protein level used designations for STAT2

fj84d07 , signal transducer and activator of transcription 2 , signal transducer and activator of transcription (AGAP000099-PA) , interferon alpha induced transcriptional activator

GENE ID SPECIES
565200 Danio rerio
712694 Macaca mulatta
1272172 Anopheles gambiae str. PEST
100270812 Salmo salar
20847 Mus musculus
288774 Rattus norvegicus
100344467 Oryctolagus cuniculus
100858732 Gallus gallus
6773 Homo sapiens
481111 Canis lupus familiaris
100719719 Cavia porcellus
396923 Sus scrofa
451996 Pan troglodytes
511023 Bos taurus
101108211 Ovis aries
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