Browse our STAT2 Proteins (STAT2)

Full name:
Signal Transducer and Activator of Transcription 2, 113kDa Proteins (STAT2)
On www.antibodies-online.com are 10 Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Proteins from 6 different suppliers available. Additionally we are shipping STAT2 Antibodies (275) and STAT2 Kits (37) and many more products for this protein. A total of 332 STAT2 products are currently listed.
Synonyms:
1600010G07Rik, AW496480, ISGF-3, P113, stat2, STAT113, wu:fj84d07
list all proteins Gene Name GeneID UniProt
STAT2 20847  
STAT2 288774  
STAT2 6773 P52630

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STAT2 Proteins (STAT2) by Origin

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More Proteins for STAT2 Interaction Partners

Atlantic Salmon (Salmo salar) Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) interaction partners

  1. The full length cDNA sequence of Atlantic salmon (Salmo salar) ssSTAT2 was determined and phylogenetic analysis of the amino acid sequence grouped this novel salmon gene to the STAT2 clade.

Mouse (Murine) Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) interaction partners

  1. this study shows that STAT2 plays a critical role in TLR-induced dendritic cell activation and cross-presentation, and

  2. this study shows that STAT2 plays a critical role in TLR-induced dendritic cell activation and cross-presentation

  3. these studies identify phosphorylation of S734-STAT2 as a new regulatory mechanism that negatively controls the type I IFN-antiviral response.

  4. IFN-I can mediate ISG expression inmixed glial cell cultures (MGCs) via ISGF3 (show IRF9 Proteins)-independent signaling pathways but with reduced efficiency, with delayed and prolonged kinetics, and is more dependent on STAT1 (show STAT1 Proteins) and STAT2 than IRF9 (show IRF9 Proteins); and 2) signaling pathways not involving STAT1 (show STAT1 Proteins), STAT2, or IRF9 (show IRF9 Proteins) play a minor role only in mediating IFN-alpha (show IFNA Proteins)-stimulated genes expression in MGCs.

  5. transcriptional activation of Adar1 (show ADAR Proteins) by IFN occurs in the absence of STAT1 (show STAT1 Proteins) by a non-canonical STAT2-dependent pathway in mouse but not human cells.

  6. IFN-alpha (show IFNA Proteins)/beta is able to drive the formation of a Stat2 and IRF-9 (show IRF9 Proteins) complex that drives the expression of a subset of IFN-stimulated genes, but with substantially delayed kinetics.

  7. Activation of STAT2/IRF9 (show IRF9 Proteins) induces a prolonged ISGF3 (show IRF9 Proteins)-like transcriptome and generates an antiviral response.

  8. In a mouse syngeneic tumor transplantation model STAT2 expression reduces tumor growth.

  9. Data suggest a role for Vc in Nanog regulation networks and reveal a novel role for STAT2 in regulating Nanog expression.

  10. Stat2 loss leads to reduced expression of NF-kappaB (show NFKB1 Proteins) target genes by affecting nuclear translocation of NF-kappaB (show NFKB1 Proteins).

Human Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) interaction partners

  1. data suggest that STAT2 plays a role in the psoriasis pathogenesis by regulating the expression of CXCL11 (show CXCL11 Proteins) and CCL5 (show CCL5 Proteins), and thereby attracting IFNgamma-producing immune cells to the skin

  2. Interferon-alpha-enhanced IL-10 expression in human CD4 T cells is regulated by STAT3, STAT2, and BATF transcription factors.

  3. the rate-limiting transition state for binding between the TAZ1 (show TAZ Proteins) domain of CREB binding protein (show CREBBP Proteins) and the intrinsically disordered transactivation domain of STAT2 (TAD (show CRTAM Proteins)-STAT2) by site-directed mutagenesis and kinetic experiments (Phi-value analysis) and found that the native protein-protein binding interface is not formed at the transition state for binding.

  4. these studies identify phosphorylation of S734-STAT2 as a new regulatory mechanism that negatively controls the type I IFN-antiviral response.

  5. Data show that moringin (GMG-ITC) had a limited inhibitory effect on IFNalpha-induced STAT1 (show STAT1 Proteins) and STAT2 activity, indicating differentially targeting JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signaling pathways.

  6. study demonstrates that overexpression of Porcine deltacoronavirus (PDCoV) nsp5 (show SPECC1 Proteins) also antagonizes IFN signaling by cleaving STAT2, an essential component of transcription factor complex ISGF3 (show STAT1 Proteins), and that PDCoV infection reduces the levels of STAT2, which may affect the innate immune response

  7. PKV VP3 associated with STAT2 and IRF9 (show IRF9 Proteins), and interfered with the formation of the STAT2-IRF9 (show IRF9 Proteins) and STAT2-STAT2 complex.

  8. The authors have discovered a novel phosphorylation of STAT2 on T387 that negatively regulates signal from the type I interferon receptor (show IFNAR1 Proteins) to the genome by transcription factor ISGF3 (show STAT1 Proteins).

  9. STAT2 recruits USP18 (show USP18 Proteins) to the type I IFN receptor subunit IFNAR2 (show IFNAR2 Proteins) via its constitutive membrane-distal STAT2-binding site.

  10. These results establish that activation of STAT (show STAT1 Proteins) pathway is essential for anti-hepatitis c virus efficacy of IFN-alpha (show IFNA Proteins).

Pig (Porcine) Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) interaction partners

  1. While La Piedad Michoacan Mexico Virus V protein does not affect the protein levels of STAT1 (show STAT1 Proteins) or STAT2, it does prevent the interferon (show IFNA Proteins)-induced phosphorylation and nuclear translocation of STAT1 (show STAT1 Proteins) and STAT2 thereby inhibiting cellular responses to interferon alpha (show IFNA Proteins)/beta.

  2. Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1 (show STAT1 Proteins)/STAT2 nuclear translocation.

  3. Nsp1beta inhibits interferon-activated (show MNDA Proteins) STAT1 (show STAT1 Proteins)/STAT2 signal transduction by inducing karyopherin-alpha1 degradation.

  4. the majority of the STAT1 (show STAT1 Proteins)/STAT2/IRF9 (show IRF9 Proteins) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked

Cow (Bovine) Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) interaction partners

  1. Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 (show STAT1 Proteins) and, to a lesser extent, STAT2.

STAT2 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with STAT2

  • signal transducer and activator of transcription 2 (stat2)
  • signal transducer and activator of transcription 2, 113kDa (STAT2)
  • signal transducer and activator of transcription (AGAP000099-PA) (STAT2)
  • signal transducer and activator of transcription 2 (Stat2)
  • signal transducer and activator of transcription 2 (LOC100344467)
  • signal transducer and activator of transcription 2-like (LOC100858732)
  • signal transducer and activator of transcription 2, 113kDa (Stat2)
  • 1600010G07Rik protein
  • AW496480 protein
  • ISGF-3 protein
  • P113 protein
  • stat2 protein
  • STAT113 protein
  • wu:fj84d07 protein

Protein level used designations for STAT2

fj84d07 , signal transducer and activator of transcription 2 , signal transducer and activator of transcription (AGAP000099-PA) , interferon alpha induced transcriptional activator

GENE ID SPECIES
565200 Danio rerio
712694 Macaca mulatta
1272172 Anopheles gambiae str. PEST
100270812 Salmo salar
20847 Mus musculus
288774 Rattus norvegicus
100344467 Oryctolagus cuniculus
100858732 Gallus gallus
6773 Homo sapiens
481111 Canis lupus familiaris
100719719 Cavia porcellus
396923 Sus scrofa
451996 Pan troglodytes
511023 Bos taurus
101108211 Ovis aries
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