Browse our anti-STAT3 (STAT3) Antibodies

Full name:
anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) Antibodies (STAT3)
On www.antibodies-online.com are 612 Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Antibodies from 41 different suppliers available. Additionally we are shipping STAT3 Kits (56) and STAT3 Proteins (34) and many more products for this protein. A total of 729 STAT3 products are currently listed.
Synonyms:
1110034C02Rik, aprf, AW109958, hies, stat3, wu:fc15d02, wu:fl59g06, Xstat3, z-Stat3
list all antibodies Gene Name GeneID UniProt
STAT3 20848 P42227
STAT3 6774 P40763
STAT3 25125 P52631

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Top referenced anti-STAT3 Antibodies

  1. Human Polyclonal STAT3 Primary Antibody for IHC (p), WB - ABIN389665 : Schick, Oakeley, Hynes, Badache: TEL/ETV6 is a signal transducer and activator of transcription 3 (Stat3)-induced repressor of Stat3 activity. in The Journal of biological chemistry 2004 (PubMed)
    Show all 8 references for 389665

  2. Human Polyclonal STAT3 Primary Antibody for EIA, IHC (p) - ABIN358234 : Wang, Wang, Zhang, Huang, Liao, Fuller: Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas. in Laboratory investigation; a journal of technical methods and pathology 2004 (PubMed)
    Show all 5 references for 358234

  3. Cow (Bovine) Polyclonal STAT3 Primary Antibody for IF, IHC - ABIN2780479 : Ohbayashi, Kawakami, Muromoto, Togi, Ikeda, Kamitani, Sekine, Honjoh, Matsuda: The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction. in Biochemical and biophysical research communications 2008 (PubMed)
    Show all 2 references for 2780479

  4. Cow (Bovine) Polyclonal STAT3 Primary Antibody for IHC, WB - ABIN2792239 : Suen, Uddin, Prow, Bowen, Hall, Bielefeldt-Ohmann: Tissue-specific transcription profile of cytokine and chemokine genes associated with flavivirus control and non-lethal neuropathogenesis in rabbits. in Virology 2016 (PubMed)
    Show all 2 references for 2792239

  5. Human Polyclonal STAT3 Primary Antibody for ELISA, WB - ABIN185692 : Palmqvist, Glover, Hsu, Lu, Bossen, Piret, Humphries, Helgason: Correlation of murine embryonic stem cell gene expression profiles with functional measures of pluripotency. in Stem cells (Dayton, Ohio) 2005 (PubMed)

  6. Cow (Bovine) Polyclonal STAT3 Primary Antibody for EIA, IF - ABIN374087 : Bromberg, Wrzeszczynska, Devgan, Zhao, Pestell, Albanese, Darnell: Stat3 as an oncogene. in Cell 1999 (PubMed)

  7. Human Polyclonal STAT3 Primary Antibody for IHC, ELISA - ABIN1531975 : Catlett-Falcone, Landowski, Oshiro, Turkson, Levitzki, Savino, Ciliberto, Moscinski, Fernández-Luna, Nuñez, Dalton, Jove: Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. in Immunity 1999 (PubMed)

  8. Human Monoclonal STAT3 Primary Antibody for WB - ABIN1449165 : Yamashita, Miyagi, Carmany-Rampey, Shimizu, Fujii, Schier, Hirano: Stat3 Controls Cell Movements during Zebrafish Gastrulation. in Developmental cell 2002 (PubMed)

More Antibodies against STAT3 Interaction Partners

Mouse (Murine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. We revealed that in mouse mesench (show IFNG Antibodies)ymal stem cells IFN-gamma-induced immunoregulation is mediated by early phosphorylation of signal transducer and activator of transcription (STAT) 1 and STAT3, which is significantly enhanced by an extracellular signal-regulated kinase 1/2-dependent mTOR inhibition, thereby promoting pSTAT1 nuclear translocation.

  2. our data demonstrate that p66a may physically interact with STAT3 to suppress its activity through posttranslational modification, which reveals a novel regulatory mechanism controlling STAT3 activation during myeloid cell differentiation.

  3. Myeloid deletion of Cul3 (show CUL3 Antibodies) led to defective STAT3 phosphorylation in colon macrophages, which was accompanied by exacerbated colonic inflammation and inflammation-driven tumorigenesis.

  4. High levels of miR-17 expression can function to up-regulate autophagy to aggravate hepatic ischemia/reperfusion injury by suppressing Stat3 expression.

  5. TRAF6 (show TRAF6 Antibodies) mediates lysine-63 ubiquitination within the SH2 (show MYO15 Antibodies) domain of STAT3, which is an essential step for STAT3 membrane recruitment and phosphorylation in response to S Typhimurium infection; results reveal a strategy in which S Typhimurium T3SS effectors broaden their functions through the activation of host proteins in a ubiquitination-dependent manner to manipulate host cells into becoming a Salmonella-friendly zone

  6. Small-scale in vivo screening identified several genes, including Cd109 (show CD109 Antibodies), that encode novel pro-metastatic factors. We uncovered signaling mediated by Janus kinases (Jaks) and the transcription factor Stat3 as a critical, pharmacologically targetable effector of CD109 (show CD109 Antibodies)-driven lung cancer metastasis

  7. the effect of STAT3 mutations on protein stability, is reported.

  8. Results suggest that interleukin-6 (IL-6 (show IL6 Antibodies)) increases VEGF-C (show VEGFC Antibodies) induction and lymphangiogenesis may involve, at least in part, Src (show SRC Antibodies)-FAK (show PTK2 Antibodies)-STAT3 cascade in lymphatic endothelial cells (LECs).

  9. miR (show MLXIP Antibodies)-155 not only directly inhibited SOCS1 (show SOCS1 Antibodies) expression, but also increased the expression of p-STAT (show STAT1 Antibodies) and PDCD4 (show PDCD4 Antibodies), as well as the production of proinflammation mediators IL-6 (show IL6 Antibodies) and TNF-alpha (show TNF Antibodies) in atherogenesis

  10. High STAT3 expression is associated with Hepatic Fibrosis.

Human Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. The results suggested the possible participation of STAT3 instead of ERK (show EPHB2 Antibodies) in the GPR110 (show GPR110 Antibodies) signaling pathways and progression of glioma.

  2. Results indicate a pathway via which microRNA miR-17-5p inhibits STAT3 and increases p53 (show TP53 Antibodies) expression to promote apoptosis in breast cancer cells.

  3. These results suggest that it may be possible for Evista to emerge as a chemoprevention agent for breast cancer and other cancers such as colon cancer or multiple myeoloma by targeting IL-6 (show IL6 Antibodies)/STAT3 signaling.

  4. A sustained exposure to IFN-gamma (show IFNG Antibodies) in human mesenchymal stem cells led to inhibition of STAT3 activity.

  5. STAT3 activation promotes ERBIN (show ERBB2IP Antibodies) expression and negatively regulates TGF-beta (show TGFB1 Antibodies) activity by the formation of a STAT3-ERBIN (show ERBB2IP Antibodies)-SMAD2 (show SMAD2 Antibodies)/3 complex.

  6. IFITM2 (show IFITM2 Antibodies) promotes gastric cancer growth and metastasis via IGF1 (show IGF1 Antibodies)/IGF1R (show IGF1R Antibodies)/STAT3 signaling pathway.

  7. Data show that succinate upregulates vascular endothelial growth factor (VEGF) expression by activation of signal transducer and activator of transcription 3 (STAT3) and extracellular regulated kinase (ERK)1 (show MAPK3 Antibodies)/2 via its receptor G-protein coupled receptor 91 (GPR91 (show SUCNR1 Antibodies)).

  8. Data show that cisplatin suppresses cervical cancer cell movement and angiogenesis via regulating miR (show MLXIP Antibodies)-29b/STAT3 axis.

  9. Suppression of GPRC5a (show GPRC5A Antibodies) results in decreased cell growth, proliferation and migration in pancreatic cancer cell lines via a STAT3 modulated pathway, independent from ERK (show EPHB2 Antibodies) activation

  10. STAT3 expression is upregulated in both HBV- and HCV-related hepatocellular carcinoma (HCC (show FAM126A Antibodies)), while hexokinase II (HK-II (show HK2 Antibodies)) is predominantly upregulated and correlated to STAT3 in HBV-related HCC (show FAM126A Antibodies)

Cow (Bovine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.

  2. Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate

  3. results show for the first time that interleukin-6 (show IL6 Antibodies) (IL), in the presence of its soluble receptor (show IFNAR1 Antibodies) (sIL (show STIL Antibodies)-6R), induces activation of JAK1 (show JAK1 Antibodies), JAK2 (show JAK2 Antibodies), and STAT1 (show STAT1 Antibodies)/STAT3 proteins in bovine articular chondrocytes

  4. peroxynitrite causes increased expression of VEGF (show VEGFA Antibodies) in vascular endothelial cells by a process that requires the activation of STAT3

  5. Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (show NOX1 Antibodies)-mediated activation of STAT3.

Pig (Porcine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets

  2. maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (show CCND2 Antibodies) and PSEN1 (show PSEN1 Antibodies) genes via a STAT3-dependent pathway

  3. Studied effect of recombinant porcine leukemia inhibitory factor (show LIF Antibodies) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (show FTH1 Antibodies)-supplemented media.

  4. Data suggest that IL-6 (interleukin 6 (show IL6 Antibodies)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (show IL6 Antibodies)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).

  5. the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.

  6. Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.

  7. STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways

  8. Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.

Rabbit Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. This is the first report of the genetic polymorphisms of the JAK1 (show JAK1 Antibodies) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.

Guinea Pig Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.

  2. Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (show MMP2 Antibodies) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.

Zebrafish Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a (show CDC25A Antibodies) expression during oogenesis. Accordingly, restoring Cdc25a (show CDC25A Antibodies) expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.

  2. PTPN9 (show PTPN9 Antibodies) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (show GATA1 Antibodies) and ZBP-89 (show ZNF148 Antibodies).

  3. Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.

  4. Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.

  5. This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.

  6. The results of this study suggested that the stat3/socs3 (show SOCS3 Antibodies) pathway is a key response in all tissue regeneration in zebrafish.

  7. stat3, a known oncogene (show RAB1A Antibodies) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.

  8. Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (show PRCP Antibodies) in neighboring cells during zebrafish gastrulation.

STAT3 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with STAT3

  • signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3) antibody
  • signal transduction and activation of transcription 3 (stat3) antibody
  • signal transducer and activator of transcription 3 (acute-phase response factor) (stat3) antibody
  • signal transducer and activator of transcription 3 (Stat3) antibody
  • signal transducer and activator of transcription 3 (acute-phase response factor) (Stat3) antibody
  • signal transducer and activator of transcription 3 (acute-phase response factor), gene 1 (stat3.1) antibody
  • 1110034C02Rik antibody
  • aprf antibody
  • AW109958 antibody
  • hies antibody
  • stat3 antibody
  • wu:fc15d02 antibody
  • wu:fl59g06 antibody
  • Xstat3 antibody
  • z-Stat3 antibody

Protein level used designations for STAT3

signal transducer and activator of transcription 3 (acute-phase response factor) , signal transducer and activator of transcription 3 , signal transduction and activation of transcription 3 , Signal transducer and activator of transcription 3 , signal transducer and activator of transcription 3-like , acute phase response factor , acute-phase response factor , DNA-binding protein APRF , Protein Stat3 , signal transducer and activator of transcription 3.1 , stat 3

GENE ID SPECIES
100011382 Monodelphis domestica
100171541 Pongo abelii
100380714 Salmo salar
100469938 Ailuropoda melanoleuca
100566559 Anolis carolinensis
100598877 Nomascus leucogenys
20848 Mus musculus
6774 Homo sapiens
25125 Rattus norvegicus
490967 Canis lupus familiaris
508541 Bos taurus
733648 Sus scrofa
420027 Gallus gallus
574128 Macaca mulatta
454682 Pan troglodytes
100348778 Oryctolagus cuniculus
100717084 Cavia porcellus
100294659 Ovis aries
779100 Xenopus laevis
30767 Danio rerio
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