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Browse our anti-STAT3 (STAT3) Antibodies

Full name:
anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) Antibodies (STAT3)
On www.antibodies-online.com are 633 Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Antibodies from 40 different suppliers available. Additionally we are shipping STAT3 Kits (50) and STAT3 Proteins (36) and many more products for this protein. A total of 746 STAT3 products are currently listed.
Synonyms:
1110034C02Rik, aprf, AW109958, hies, stat3, wu:fc15d02, wu:fl59g06, Xstat3, z-Stat3
list all antibodies Gene Name GeneID UniProt
STAT3 20848 P42227
STAT3 6774 P40763
STAT3 25125 P52631

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Top referenced anti-STAT3 Antibodies

  1. Human Polyclonal STAT3 Primary Antibody for IHC (p), WB - ABIN389665 : Schick, Oakeley, Hynes, Badache: TEL/ETV6 is a signal transducer and activator of transcription 3 (Stat3)-induced repressor of Stat3 activity. in The Journal of biological chemistry 2004 (PubMed)
    Show all 8 references for ABIN389665

  2. Human Polyclonal STAT3 Primary Antibody for EIA, IHC (p) - ABIN358234 : Wang, Wang, Zhang, Huang, Liao, Fuller: Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas. in Laboratory investigation; a journal of technical methods and pathology 2004 (PubMed)
    Show all 5 references for ABIN358234

  3. Human Polyclonal STAT3 Primary Antibody for EIA, IHC (p) - ABIN358233 : Kato, Sakamoto, Kutsuna, Kimura-Eto, Hato, Kitagawa: Proteolytic conversion of STAT3alpha to STAT3gamma in human neutrophils: role of granule-derived serine proteases. in The Journal of biological chemistry 2004 (PubMed)
    Show all 5 references for ABIN358233

  4. Cow (Bovine) Polyclonal STAT3 Primary Antibody for IHC, WB - ABIN2792239 : Ohbayashi, Kawakami, Muromoto, Togi, Ikeda, Kamitani, Sekine, Honjoh, Matsuda: The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction. in Biochemical and biophysical research communications 2008 (PubMed)
    Show all 2 references for ABIN2792239

  5. Chicken Polyclonal STAT3 Primary Antibody for IF, IHC - ABIN2780479 : Deng, Chen, Li, Liu, Niu, Zhou, Li, Ke, Mo et al.: Bone marrow mesenchymal stromal cells with support of bispecific antibody and ultrasound-mediated microbubbles prevent myocardial fibrosis via the signal transducer and activators of transcription ... in Cytotherapy 2011 (PubMed)
    Show all 2 references for ABIN2780479

  6. Human Polyclonal STAT3 Primary Antibody for IHC, ELISA - ABIN1531975 : Catlett-Falcone, Landowski, Oshiro, Turkson, Levitzki, Savino, Ciliberto, Moscinski, Fernández-Luna, Nuñez, Dalton, Jove: Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. in Immunity 1999 (PubMed)

  7. Human Monoclonal STAT3 Primary Antibody for WB - ABIN1449165 : Yamashita, Miyagi, Carmany-Rampey, Shimizu, Fujii, Schier, Hirano: Stat3 Controls Cell Movements during Zebrafish Gastrulation. in Developmental cell 2002 (PubMed)

  8. Cow (Bovine) Polyclonal STAT3 Primary Antibody for EIA, IF - ABIN374087 : Bromberg, Wrzeszczynska, Devgan, Zhao, Pestell, Albanese, Darnell: Stat3 as an oncogene. in Cell 1999 (PubMed)

  9. Dog (Canine) Polyclonal STAT3 Primary Antibody for WB - ABIN782995 : Palmqvist, Glover, Hsu, Lu, Bossen, Piret, Humphries, Helgason: Correlation of murine embryonic stem cell gene expression profiles with functional measures of pluripotency. in Stem cells (Dayton, Ohio) 2005 (PubMed)

More Antibodies against STAT3 Interaction Partners

Mouse (Murine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. findings demonstrate that advanced gastric tumorigenesis requires oncogenic KRAS or BRAF (show BRAF Antibodies) in concert with aberrant STAT3 activation in epithelial precursor cells of the glandular stomach

  2. phosphorylated Hsp27 (show HSPB1 Antibodies) stimulates autophagy and lipid droplet clearance and interacts with STAT3.

  3. Treatment with Tetrandrine (TET) resulted in downregulation of phosphorylated NFkappaB p65 (show NFkBP65 Antibodies) and reduction of the production of TNFalpha (show TNF Antibodies) and IL1beta (show IL1B Antibodies). In addition, the phosphorylation of ERK (show EPHB2 Antibodies) and STAT3 was decreased by TET in activated macrophages.

  4. fad104 (show FNDC3B Antibodies) suppressed anchorage-independent growth of melanoma cells, and the N-terminal region of FAD104 (show FNDC3B Antibodies) is essential for inhibiting malignant transformation and STAT3 activity

  5. The data demonstrated that boldine may be beneficial in colitis through selective immunomodulatory effects, which may be mediated, at least in part, by inhibition of p65-NF-kappaB (show NFkBP65 Antibodies) and STAT3 signaling pathways

  6. Study showed that suppression of STAT3, STAT5 (show STAT5A Antibodies), and STAT6 (show STAT6 Antibodies) and overexpression of the proapoptotic factor STAT1 (show STAT1 Antibodies), which provides p53 (show TP53 Antibodies)-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 (show ERBB2 Antibodies) tyrosine kinase receptor (show KDR Antibodies) overexpression promotes neuronal survival through activation of STAT (show STAT1 Antibodies)-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1 (show STAT1 Antibodies)

  7. inflammatory cytokine insults stimulate epithelial-to-mesenchymal transition (EMT (show ITK Antibodies)) as well as the endocrine program in human pancreatic ductal cells via STAT3-dependent NGN3 (show NEUROG3 Antibodies) activation.

  8. Study provides evidence for new immunoregulatory mechanisms of STAT3 during intestinal inflammation.

  9. IL-6 (show IL6 Antibodies)/P-STAT3 activation influences p63 (show CKAP4 Antibodies) isoform expression in healing wounds, which may contribute to wound-induced hair follicle neogenesis.

  10. IL6 (show IL6 Antibodies)/STAT3 signalling dysregulation, caused by IL6 (show IL6 Antibodies) deficiency, resulted in skewing of the immune modulatory properties of mesenchymal stem cells to favour a pro-inflammatory profile.

Human Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. Huaier aqueous extract inhibited JAK2 (show JAK2 Antibodies)/STAT3 and MAPK (show MAPK1 Antibodies) signaling pathways.

  2. MiR-451 may function as a potential suppressor of tumor angiogenesis in HCC by targeting IL-6R-STAT3-VEGF signaling, suggesting.

  3. Data show that the activation of STAT3 protein upregulated human cervical cancer oncogene (show RAB1A Antibodies) (HCCR) expression in gastric cancer cells.

  4. These results suggested that STAT3 activation represents a potential target in nasal Nasal-type natural killer/T-cell lymphoma(NKTCL). WP1066 may be a promising agent in antitumor therapy against nasal NKTCL.

  5. The findings of the present study suggested that miR (show MLXIP Antibodies)-124 functioned as tumor suppressor in retinoblastoma , at least in part, by targeting STAT3, and that it could serve as a potential candidate for retinoblastoma therapeutics.

  6. Imatinib-resistant K562/G01 cells expressed significantly higher levels of STAT3 and RPS27a (show RPS27A Antibodies) compared with those of K562 cells.

  7. results suggest that methanethiosulfonate moiety can be considered a useful scaffold in the preparation of new direct STAT3 inhibitors

  8. Data show that Rac1 induced nuclear import of STAT3 by physical binding, and nuclear STAT3 directly activated the transcription of essential oocyte-specific genes, including Jagged1 (show JAG1 Antibodies), GDF9 (show GDF9 Antibodies) and BMP15 (show BMP15 Antibodies).

  9. High STAT3 expression is associated with leukemia.

  10. results suggest that the activation of the IL6/STAT3 pathway in tumor cells may provide a survival advantage during anti-VEGF treatment, suggesting its utility as a source of response biomarkers and as a therapeutic target to heighten efficacious results

Cow (Bovine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.

  2. Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate

  3. results show for the first time that interleukin-6 (show IL6 Antibodies) (IL), in the presence of its soluble receptor (show IFNAR1 Antibodies) (sIL (show STIL Antibodies)-6R), induces activation of JAK1 (show JAK1 Antibodies), JAK2 (show JAK2 Antibodies), and STAT1 (show STAT1 Antibodies)/STAT3 proteins in bovine articular chondrocytes

  4. peroxynitrite causes increased expression of VEGF (show VEGFA Antibodies) in vascular endothelial cells by a process that requires the activation of STAT3

  5. Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (show NOX1 Antibodies)-mediated activation of STAT3.

Pig (Porcine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (show CCND2 Antibodies) and PSEN1 (show PSEN1 Antibodies) genes via a STAT3-dependent pathway

  2. Studied effect of recombinant porcine leukemia inhibitory factor (show LIF Antibodies) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (show FTH1 Antibodies)-supplemented media.

  3. Data suggest that IL-6 (interleukin 6 (show IL6 Antibodies)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (show IL6 Antibodies)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).

  4. the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.

  5. Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.

  6. STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways

  7. Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.

Rabbit Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. This is the first report of the genetic polymorphisms of the JAK1 (show JAK1 Antibodies) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.

Guinea Pig Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.

  2. Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (show MMP2 Antibodies) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.

Zebrafish Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. PTPN9 (show PTPN9 Antibodies) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (show GATA1 Antibodies) and ZBP-89 (show ZNF148 Antibodies).

  2. Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.

  3. Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.

  4. This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.

  5. The results of this study suggested that the stat3/socs3 (show SOCS3 Antibodies) pathway is a key response in all tissue regeneration in zebrafish.

  6. stat3, a known oncogene (show RAB1A Antibodies) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.

  7. Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (show PRCP Antibodies) in neighboring cells during zebrafish gastrulation.

STAT3 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with STAT3

  • signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3) antibody
  • signal transduction and activation of transcription 3 (stat3) antibody
  • signal transducer and activator of transcription 3 (acute-phase response factor) (stat3) antibody
  • signal transducer and activator of transcription 3 (Stat3) antibody
  • signal transducer and activator of transcription 3 (acute-phase response factor) (Stat3) antibody
  • signal transducer and activator of transcription 3 (acute-phase response factor), gene 1 (stat3.1) antibody
  • 1110034C02Rik antibody
  • aprf antibody
  • AW109958 antibody
  • hies antibody
  • stat3 antibody
  • wu:fc15d02 antibody
  • wu:fl59g06 antibody
  • Xstat3 antibody
  • z-Stat3 antibody

Protein level used designations for STAT3

signal transducer and activator of transcription 3 (acute-phase response factor) , signal transducer and activator of transcription 3 , signal transduction and activation of transcription 3 , Signal transducer and activator of transcription 3 , signal transducer and activator of transcription 3-like , acute phase response factor , acute-phase response factor , DNA-binding protein APRF , Protein Stat3 , signal transducer and activator of transcription 3.1 , stat 3

GENE ID SPECIES
100011382 Monodelphis domestica
100171541 Pongo abelii
100380714 Salmo salar
100469938 Ailuropoda melanoleuca
100566559 Anolis carolinensis
100598877 Nomascus leucogenys
20848 Mus musculus
6774 Homo sapiens
25125 Rattus norvegicus
490967 Canis lupus familiaris
508541 Bos taurus
733648 Sus scrofa
420027 Gallus gallus
574128 Macaca mulatta
454682 Pan troglodytes
100348778 Oryctolagus cuniculus
100717084 Cavia porcellus
100294659 Ovis aries
779100 Xenopus laevis
30767 Danio rerio
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