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anti-Dog (Canine) STAT3 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended STAT3 Antibody (supplied by: Log in to see )

Antigen
Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Antibodies
  • 1110034C02Rik
  • APRF
  • Aprf
  • aprf
  • AW109958
  • hies
  • HIES
  • stat3
  • wu:fc15d02
  • wu:fl59g06
  • Xstat3
  • z-Stat3
Epitope
C-Term, Isoform 1
112
93
85
28
21
17
16
16
14
13
13
13
8
5
5
5
5
4
4
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
544
265
207
29
23
23
13
11
10
5
4
3
3
2
2
2
2
1
1
1
1
1
Host
Goat
466
109
33
4
1
1
Clonality
Polyclonal
Conjugate
This STAT3 antibody is un-conjugated
24
22
18
13
12
11
8
5
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
502
238
216
79
74
70
52
32
23
13
12
11
9
7
3
3
2
2
2
2
1
1
1
1
Supplier
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Catalog No. ABIN374087
$ 379.50
Plus shipping costs $45.00

Top referenced anti-STAT3 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Similar anti-STAT3 Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus) Dog (Canine) Cow (Bovine) Pig (Porcine)
Western Blotting (WB) 454 Antibodies 201 Antibodies 157 Antibodies 20 Antibodies 15 Antibodies 15 Antibodies
Proximity Ligation Assay (PLA) 3 Antibodies
Intracellular Staining (ICS) 13 Antibodies 13 Antibodies 4 Antibodies 2 Antibodies
Intracellular Flow Cytometry (ICFC) 2 Antibodies 2 Antibodies 2 Antibodies
Immunostaining (ISt) 1 Antibodies
Immunoprecipitation (IP) 9 Antibodies 54 Antibodies 50 Antibodies 30 Antibodies 5 Antibodies

General

Antigen Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Antibodies
Epitope C-Term, Isoform 1
(112), (93), (85), (28), (21), (17), (16), (16), (14), (13), (13), (13), (8), (5), (5), (5), (5), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
(544), (265), (207), (29), (23), (23), (13), (11), (10), (5), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Host Goat
(466), (109), (33), (4), (1), (1)
Clonality
Polyclonal
Conjugate This STAT3 antibody is un-conjugated
(24), (22), (18), (13), (12), (11), (8), (5), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(502), (238), (216), (79), (74), (70), (52), (32), (23), (13), (12), (11), (9), (7), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Pubmed 1 reference available
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Product Details anti-STAT3 Antibody

Target Details STAT3 Application Details Handling References for anti-STAT3 Antibody (ABIN374087) Images
Sequence DMELTSECAT SPM
Specificity This antibody is expected to recognize Isoform 1 (NP_644805.1) and Isoform 2 (NP_003141.2).
Cross-Reactivity (Details) Species reactivity (expected):Canine (Dog), Pig and Bovine.
Species reactivity (tested):Human, Mouse, Rat.
Purification Immunoaffinity Chromatography
Immunogen Peptide from C-Terminus of the protein sequence according to NP_003141.2, NP_644805.1. Genename: STAT3

Target Details STAT3

Product Details anti-STAT3 Antibody Application Details Handling References for anti-STAT3 Antibody (ABIN374087) Images back to top
Antigen
Alternative Name STAT3 (STAT3 Antibody Abstract)
Background The STAT3 protein is expressed in most cell types and is activated by multiple cytokines and growth factors including: IFNa, IL10, IL6, IL11, IL12, IL2, EGF, among others. STAT3 beta appears to be activated by both EGF and IL6, but STAT3 alpha is only activated by EGF. STAT3 binds to DNA as either a homodimer or as a heterodimer with STAT1. STAT3 interacts with the APRE acute phase response element) and SIE (csis inducible element). STAT4, predominantly expressed in testis and myeloid cells, is activated by ILl2. STAT5 is activated by prolactin and IL3. STAT6 participates in signaling pathways mediated by IL4.Synonyms: APRF, Acute-phase response factor, STAT-3, Signal transducer and activator of transcription 3
Gene ID 6774
NCBI Accession NP_003141
UniProt P40763
Research Area Embryogenesis, Embryonic stem cells, Transcription Factors, Signaling, Receptors, Inflammation
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-STAT3 Antibody Target Details STAT3 Handling References for anti-STAT3 Antibody (ABIN374087) Images back to top
Application Notes Peptide ELISA: 1/128000. Western blot: 1-3 μg/mL. Approx.90 kDa band observed in lysates of NIH3T3 (calculatedMW of 88.0 kDa according to NP_644805.1 and of 88.1 according to NP_003141.2). Immunohistochemistry: Rommended overnight staining at 10 μg/mL (See picture). Stainsmouse thymic medulla and not the cortex.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-STAT3 Antibody Target Details STAT3 Application Details References for anti-STAT3 Antibody (ABIN374087) Images back to top
Concentration 0.5 mg/mL
Buffer Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C.

References for anti-STAT3 Antibody (ABIN374087)

Product Details anti-STAT3 Antibody Target Details STAT3 Application Details Handling Images back to top
Background publications

Bromberg, Wrzeszczynska, Devgan, Zhao, Pestell, Albanese, Darnell: "Stat3 as an oncogene." in: Cell, Vol. 98, Issue 3, pp. 295-303, 1999

Images

Product Details anti-STAT3 Antibody Target Details STAT3 Application Details Handling References for anti-STAT3 Antibody (ABIN374087) back to top
Supplier Images
 image for anti-STAT3 antibody (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor)) (C-Term) (ABIN374087) anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (C-Term), (Isoform 1) antibody