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anti-Human STAT3 antibody for Intracellular Flow Cytometry

Recommended STAT3 Antibody (supplied by: Log in to see )

Antigen
Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Antibodies
  • 1110034C02Rik
  • APRF
  • Aprf
  • aprf
  • AW109958
  • hies
  • HIES
  • stat3
  • wu:fc15d02
  • wu:fl59g06
  • Xstat3
  • z-Stat3
Reactivity
Human, Mouse (Murine), Rat (Rattus)
544
265
207
30
24
24
13
11
10
5
4
3
3
2
2
2
2
1
1
1
1
1
Host
Rabbit
465
109
34
4
1
1
Clonality
Polyclonal
Conjugate
This STAT3 antibody is un-conjugated
24
22
18
13
12
11
8
5
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Intracellular Flow Cytometry (ICFC)
503
238
216
80
75
70
52
32
23
13
12
12
9
7
3
3
2
2
2
1
1
1
1
1
Supplier
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Available images

Catalog No. ABIN2665503
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.00087283365 ABIN2665502 ICFC Rabbit IgG Log in to see Polyclonal

Top referenced anti-STAT3 antibody for Intracellular Flow Cytometry

Similar anti-STAT3 Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus)
Western Blotting (WB) 454 Antibodies 201 Antibodies 157 Antibodies
Proximity Ligation Assay (PLA) 3 Antibodies
Intracellular Staining (ICS) 13 Antibodies 13 Antibodies 4 Antibodies
Intracellular Flow Cytometry (ICFC) 2 Antibodies 2 Antibodies 2 Antibodies
Immunostaining (ISt) 1 Antibodies
Immunoprecipitation (IP) 54 Antibodies 50 Antibodies 30 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 71 Antibodies 37 Antibodies 33 Antibodies
Immunohistochemistry (IHC) 206 Antibodies 114 Antibodies 92 Antibodies

General

Antigen Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(544), (265), (207), (30), (24), (24), (13), (11), (10), (5), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Host Rabbit
(465), (109), (34), (4), (1), (1)
Clonality (Clone)
Polyclonal   ( )
Conjugate This STAT3 antibody is un-conjugated
(24), (22), (18), (13), (12), (11), (8), (5), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Intracellular Flow Cytometry (ICFC)
(503), (238), (216), (80), (75), (70), (52), (32), (23), (13), (12), (12), (9), (7), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Pubmed 4 references available
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Product Details anti-STAT3 Antibody

Target Details STAT3 Application Details Handling References for anti-STAT3 Antibody (ABIN2665503) Images
Cross-Reactivity (Details) Does not react with STAT3b
Purification The antibody was purified by antigen-affinity chromatography.
Clone Poly6246
Isotype IgG

Target Details STAT3

Product Details anti-STAT3 Antibody Application Details Handling References for anti-STAT3 Antibody (ABIN2665503) Images back to top
Antigen
Alternative Name STAT3 (STAT3 Antibody Abstract)
Background STAT 3 is an 88 kD member of the STAT (signal transducer and activators of transcription) protein family that is phosphorylated in response to cytokine receptor-associated kinase activity. Phosphorylation of STAT 3 induces nuclear translocation to activate transcription. STAT3 is expressed in brain, heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. STAT 3 forms both homo- and heterotrimers and is involved in the activation of genes required for cell growth and apoptosis. STAT 3 is also involved in gp130 signaling and binds to IL-6 response elements in various acute phase protein promoters. STAT 3 is phosphorylated by signaling from IFNs, EGF, FGF, IL-5, HGF, LIF, and BMP2. STAT 3 activity is inhibited by PIAS3 and GRIM-19 and can also be regulated by Rac1 protein. STAT 3 interacts with Rac1, STAT 1, and NCOA1 proteins. The Poly6246 antibody recognizes the C-terminal region of human, mouse, and rat STAT3 and has been shown to be useful for Western blotting, immunoprecipitation, and immunohistochemistry. The Poly6246 antibody does not react with STAT3b.
Research Area Embryogenesis, Embryonic stem cells, Transcription Factors, Signaling, Receptors, Inflammation
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-STAT3 Antibody Target Details STAT3 Handling References for anti-STAT3 Antibody (ABIN2665503) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-STAT3 Antibody Target Details STAT3 Application Details References for anti-STAT3 Antibody (ABIN2665503) Images back to top
Format Liquid
Buffer phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % gelatin.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-STAT3 Antibody (ABIN2665503)

Product Details anti-STAT3 Antibody Target Details STAT3 Application Details Handling Images back to top
Background publications

Lufei, Ma, Huang, Zhang, Novotny-Diermayr, Ong, Cao: "GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction." in: The EMBO journal, Vol. 22, Issue 6, pp. 1325-35, 2003

Deo, Axelrad, Robert, Marcheselli, Bazan, Hunt et al.: "Phosphorylation of STAT-3 in response to basic fibroblast growth factor occurs through a mechanism involving platelet-activating factor, JAK-2, and Src in human umbilical vein endothelial cells. ..." in: The Journal of biological chemistry, Vol. 277, Issue 24, pp. 21237-45, 2002

Pfeffer, Mullersman, Pfeffer, Murti, Shi, Yang: "STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor." in: Science (New York, N.Y.), Vol. 276, Issue 5317, pp. 1418-20, 1997

Akira, Nishio, Inoue, Wang, Wei, Matsusaka, Yoshida, Sudo, Naruto, Kishimoto: "Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway." in: Cell, Vol. 77, Issue 1, pp. 63-71, 1994

Images

Product Details anti-STAT3 Antibody Target Details STAT3 Application Details Handling References for anti-STAT3 Antibody (ABIN2665503) back to top
Supplier Images
Western Blotting (WB) image for anti-STAT3 antibody (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor)) (ABIN2665503) anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) antibody