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Human STAT3 ELISA Kit for Cell ELISA - ABIN1981839
Kanai, Konda, Nakajima, Izumi, Kanda, Nanakin, Kubohara, Chiba: Differentiation-inducing factor-1 (DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK-dependent pathway. in Oncogene 2003
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Human STAT3 ELISA Kit for Sandwich ELISA - ABIN625232
Sharma, Yang, Xi, Grotta, Aronowski, Savitz: IL-10 directly protects cortical neurons by activating PI-3 kinase and STAT-3 pathways. in Brain research 2011
Show all 2 Pubmed References
Human STAT3 ELISA Kit for Sandwich ELISA - ABIN625245
Tukaj, Grüner, Tukaj, Zillikens, Kasperkiewicz: Calcitriol exerts anti-inflammatory effects in keratinocytes treated with autoantibodies from a patient with bullous pemphigoid. in Journal of the European Academy of Dermatology and Venereology : JEADV 2015
After Dox treatment, the protein expression of p-Jak2 (show JAK2 ELISA Kits) and p-Stat3 levels was significantly increased in MT(+/+) cardiomyocytes, suggesting that the JAK2 (show JAK2 ELISA Kits)/STAT3 pathway was partially involved in MT protection against Dox-induced cardiotoxicity
Studied effect of Coptis Chinensis on glioma cells; results showed Coptis Chinensis induced cell cycle arrest and apoptosis in glioma cells, down-regulated the signal transducer and activator oftranscription 3 (STAT3) phosphorylation levels, and reduced the expression of histone deacetylase 3 (HDAC3 (show HDAC3 ELISA Kits)).
M1 macrophages with inhibited STAT3, STAT6 (show STAT6 ELISA Kits) and/or SMAD3 (show SMAD3 ELISA Kits) effectively restrict tumor growth. The findings justify the development of new anti-tumor cell therapy technology.
Our data suggest that the inhibition of sRAGE on I/R-induced apoptosis is associated with activation and expression of proteasome, including improved proteasome activity and elevated beta1i (show PSMB9 ELISA Kits) and beta5i expression mediated by STAT3 activation. We predict that sRAGE is a novel intervention to target UPS activation for preventing and treating myocardial apoptosis.
our data indicate that luteolin diminishes the proinflammatory mediators NO, inflammatory cytokines and the expression of their regulatory genes, iNOS (show NOS2 ELISA Kits) and COX-2 (show COX2 ELISA Kits), in PRV-infected RAW264.7 cells by inhibiting STAT1 (show STAT1 ELISA Kits)/3 dependent NF-kappaB (show NFKB1 ELISA Kits) activation and inducing Nrf2mediated HO-1 (show HMOX1 ELISA Kits) expression.
activation of beta2-AR accelerated hepatocyte proliferation and improved recellularized liver function by mediating the IL-6 (show IL6 ELISA Kits)/Stat 3 signalling pathway, indicating that nervous system regulation may be an essential component contributing to the complexity of recellularized liver in tissue engineering
Stat3 mediates the expression of iNOS (show NOS2 ELISA Kits) to promote IFNgamma/TNFalpha (show TNF ELISA Kits)-induced muscle atrophy.
BMI1 (show BMI1 ELISA Kits) and MEL18 (show PCGF2 ELISA Kits) contribute to the development of colitis-associated cancer in mice by promoting proliferation and reducing apoptosis via suppressing expression of Reg3b. REG3B negatively regulates cytokine-induced activation of STAT3 in colon epithelial cells.
In this study, chronic UVB irradiation induced the expression of IL-10 (show IL10 ELISA Kits) and JAK1 (show JAK1 ELISA Kits) that eventually activates the STAT3 which leads to the transcription of proliferative and antiapoptotic markers.
Binding of signal transducer and activator of transcription 3 (STAT3) to cyclophilin D (CypD) was important for reducing mitochondrial reactive oxygen species (ROS) production after oxidative stress.
STAT3 S-nitrosylation was associated with inducible nitric oxide synthase (iNOS (show NOS2 ELISA Kits))-produced nitric oxide (NO) and S-nitrosoglutathione (GSNO), whereas S-glutathionylation of STAT3 was associated with cellular oxidative stress.
Data show that miR (show MLXIP ELISA Kits)-222-3p targeted SOCS3 (show SOCS3 ELISA Kits) genes and down-regulation of SOCS3 (show SOCS3 ELISA Kits) correlated with an increased expression of STAT3 activation.
Mitochondrial GRIM-19 (show NDUFA13 ELISA Kits) could not only serve as an valuable prognostic biomarker for Gastric cancer development, but also as a potential therapeutic target for STAT3-dependent carcinogenesis of Gastric cancer.
Data show that MLLT11/AF1q (show MLLT11 ELISA Kits)-induced PDGFR (show PDGFRB ELISA Kits) signaling enhanced STAT3 activity through Src kinase (show CSK ELISA Kits) activation.
We found that a significant higher gastric cancer risk was associated with IL-6 (show IL6 ELISA Kits) rs2069837G variant genotypes and JAK1 (show JAK1 ELISA Kits) rs2230587A variant genotypes
In summary, this study has shown that LIF (show LIF ELISA Kits) is implicated in the HG-mediated inhibition of osteoblast differentiation, via promoting STAT3/SOCS3 (show SOCS3 ELISA Kits) signaling. This study may provide insights into the signal pathway of HG-induced bone loss or delayed injured joint healing.
data indicates that Blcap (show BLCAP ELISA Kits) is a novel Stat3 interaction partner and suggests a role for Blcap (show BLCAP ELISA Kits) in the Stat3-mediated progression of precancerous lesions to invasive tumors of the bladder
Data suggest that the BRG1 (show SMARCA4 ELISA Kits)/STAT3/VEGFC (show VEGFC ELISA Kits) in tumor-associated lymphangiogenesis might lead to the discovery of novel therapeutic targets in the treatment of cancers with BRG1 (show SMARCA4 ELISA Kits) loss of function.
The indirect co-culture of SCLC cells and macrophages induced STAT3 activation in both cell types, and macrophage-derived culture supernatant (CS) significantly activated STAT3 in SCLC cells.
The sensitivity of chronic lymphocytic leukemia cells to in vitro spontaneous apoptosis is co-regulated by constitutively activated STAT3 and NF-kappaB (show NFKB1 ELISA Kits) and reflects the in vivo chemo-responsiveness and clinical outcomes.
STA3 (show ARHGEF3 ELISA Kits) facilitates TLR4 (show TLR4 ELISA Kits)-dependent IL-6 (show IL6 ELISA Kits) and IL-8 (show IL8 ELISA Kits) production via IL-6 (show IL6 ELISA Kits) receptor-positive feedback in endometrial cells.
STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.
Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate
results show for the first time that interleukin-6 (show IL6 ELISA Kits) (IL), in the presence of its soluble receptor (show IFNAR1 ELISA Kits) (sIL (show STIL ELISA Kits)-6R), induces activation of JAK1 (show JAK1 ELISA Kits), JAK2 (show JAK2 ELISA Kits), and STAT1 (show STAT1 ELISA Kits)/STAT3 proteins in bovine articular chondrocytes
peroxynitrite causes increased expression of VEGF (show VEGFA ELISA Kits) in vascular endothelial cells by a process that requires the activation of STAT3
Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (show NOX1 ELISA Kits)-mediated activation of STAT3.
this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (show CCND2 ELISA Kits) and PSEN1 (show PSEN1 ELISA Kits) genes via a STAT3-dependent pathway
Studied effect of recombinant porcine leukemia inhibitory factor (show LIF ELISA Kits) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (show FTH1 ELISA Kits)-supplemented media.
Data suggest that IL-6 (interleukin 6 (show IL6 ELISA Kits)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (show IL6 ELISA Kits)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).
the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.
Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.
STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways
Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.
This is the first report of the genetic polymorphisms of the JAK1 (show JAK1 ELISA Kits) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.
Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.
Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (show MMP2 ELISA Kits) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.
Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a (show CDC25A ELISA Kits) expression during oogenesis. Accordingly, restoring Cdc25a (show CDC25A ELISA Kits) expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.
PTPN9 (show PTPN9 ELISA Kits) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (show GATA1 ELISA Kits) and ZBP-89 (show ZNF148 ELISA Kits).
Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.
Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.
This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.
The results of this study suggested that the stat3/socs3 (show SOCS3 ELISA Kits) pathway is a key response in all tissue regeneration in zebrafish.
stat3, a known oncogene (show RAB1A ELISA Kits) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.
Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (show PRCP ELISA Kits) in neighboring cells during zebrafish gastrulation.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 3 (acute-phase response factor)
, signal transducer and activator of transcription 3
, signal transduction and activation of transcription 3
, Signal transducer and activator of transcription 3
, signal transducer and activator of transcription 3-like
, acute phase response factor
, acute-phase response factor
, DNA-binding protein APRF
, Protein Stat3
, signal transducer and activator of transcription 3.1
, stat 3