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Human STAT3 ELISA Kit for Cell ELISA - ABIN1981839
Kanai, Konda, Nakajima, Izumi, Kanda, Nanakin, Kubohara, Chiba: Differentiation-inducing factor-1 (DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK-dependent pathway. in Oncogene 2003
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Human STAT3 ELISA Kit for Sandwich ELISA - ABIN625232
Sharma, Yang, Xi, Grotta, Aronowski, Savitz: IL-10 directly protects cortical neurons by activating PI-3 kinase and STAT-3 pathways. in Brain research 2011
Show all 2 Pubmed References
Human STAT3 ELISA Kit for Sandwich ELISA - ABIN625245
Tukaj, Grüner, Tukaj, Zillikens, Kasperkiewicz: Calcitriol exerts anti-inflammatory effects in keratinocytes treated with autoantibodies from a patient with bullous pemphigoid. in Journal of the European Academy of Dermatology and Venereology : JEADV 2015
Stat3 regulates self-renewal of adult muscle satellite cells during injury-induced muscle regeneration through various partners, such as Pax7 (show PAX7 ELISA Kits).
cytokine-activated STAT3 and STAT6 cooperate in macrophages to promote a secretory phenotype that enhances tumor progression in a cathepsin-dependent manner.
this study shows that the upregulation of IL-10Ra (show IL10RA ELISA Kits) by STAT3 contributed to the suppressive function of dendritic cellss following histone deacetylase (show HDAC1 ELISA Kits) inhibition
APPL1 (show APPL1 PLURAL_@2013@)-SirT1 (show SIRT1 PLURAL_@2013@)-STAT3 pathway mediated adiponectin (show ADIPOQ PLURAL_@2013@) signaling in primary hepatocytes.
HDL (show HSD11B1 ELISA Kits)-associated sphingosine 1-phosphate inhibits macrophage apoptosis by stimulating STAT3 activity and survivin (show BIRC5 ELISA Kits) expression.
loss of Fyn (show FYN ELISA Kits) in the kidney prevents unilateral ureteral obstruction-induced tubulointerstitial fibrosis, mediated by a reduction in STAT3 phosphorylation
Results provide genetic evidence indicating that mTOR (show FRAP1 ELISA Kits) and Raptor (show RPTOR ELISA Kits) are required for sensory axon regeneration enhanced by peripheral lesions in mice, whereas Rictor (show RICTOR ELISA Kits) plays a minor role. The peripheral lesion activates rapamycin-resistant mTOR (show FRAP1 ELISA Kits) signaling to modulate Stat3 activity and further promotes axon regeneration.
These data describe a novel regulatory mechanism through which STAT3 and the Ikaros (show IKZF1 ELISA Kits) zinc finger transcription factors Aiolos (show IKZF3 ELISA Kits) and Ikaros (show IKZF1 ELISA Kits) cooperate to regulate Bcl-6 (show BCL6 ELISA Kits) expression.
Transplantation from GRIM19 (show NDUFA13 ELISA Kits)-overexpressing cells downregulated the expression of nuclear factor of activated T cells (NFATc1 (show NFATC1 ELISA Kits)) but promoted the expression of regulator of calcineurin (RCAN)3 (show RCAN3 ELISA Kits) while downregulating NFAT (show NFATC1 ELISA Kits)-dependent cytokine gene expression.
Data suggest MHV68 RTA (show RBM9 ELISA Kits) specifically recognizes and recruits activated (phosphorylated at Tyr705) host Stat3 during lytic phase of infection; Stat3, once phosphorylated at Tyr705, avidly binds consensus target site in promoters of regulated genes. (MHV68 = murine gammaherpesvirus 68; RTA (show RBM9 ELISA Kits) = replication and transcription activator coded for by ORF50; Stat3 = signal transducer and activator of transcription 3 protein)
High STAT3 expression is associated with recurrence in Glioma.
IL-27 (show IL27 ELISA Kits) stimulation activated STAT1 (show STAT1 ELISA Kits) and STAT3 in HeLa and T98G cells, suggesting that IL-27 (show IL27 ELISA Kits) engages the STAT1 (show STAT1 ELISA Kits)/3 pathway, which then leads to the upregulation of IL-6 (show IL6 ELISA Kits), IP-10 (show CXCL10 ELISA Kits), and MIG (show CXCL9 ELISA Kits)
STAT3 and ATG12 (show ATG12 ELISA Kits) are targets of miR (show MLXIP ELISA Kits)-454-3p.
luteolin inhibited STAT3 activation through disrupting the binding of HSP-90 to STAT3, which promoted its interaction to SHP-1.
High STAT3 expression is associated with B-cell lymphoma.
PAI-1 (show SERPINE1 ELISA Kits) was identified as the target gene of miR (show MLXIP ELISA Kits)-34a and activated the Stat3 signaling pathway to promote epithelial-mesenchymal transition in non-small cell lung cancer cells.
These results suggest that miR146a may regulate SOCS1 (show SOCS1 ELISA Kits)/STAT3 and cytokine signalling in monocytes, directing T-cell differentiation and balancing immune clearance and immune injury during chronic viral infection.
High STAT3 expression is associated with neuroblastoma (show ARHGEF16 ELISA Kits).
simvastatin also increased p21 (show CDKN1A ELISA Kits) and p27 (show PAK2 ELISA Kits) expression in tumor sections by reducing Skp2 expression and inducing AMPK (show PRKAA1 ELISA Kits) activation and STAT3 suppression in the same tumor tissues.
Overexpression of REP1 (show CHM ELISA Kits) in BEAS-2B cells enhanced cell growth and anchorage-independent colony formation with little increase in EGFR (show EGFR ELISA Kits) level and STAT3 activation.
STA3 (show ARHGEF3 ELISA Kits) facilitates TLR4 (show TLR4 ELISA Kits)-dependent IL-6 (show IL6 ELISA Kits) and IL-8 (show IL8 ELISA Kits) production via IL-6 (show IL6 ELISA Kits) receptor-positive feedback in endometrial cells.
STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.
Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate
results show for the first time that interleukin-6 (show IL6 ELISA Kits) (IL), in the presence of its soluble receptor (show IFNAR1 ELISA Kits) (sIL (show STIL ELISA Kits)-6R), induces activation of JAK1 (show JAK1 ELISA Kits), JAK2 (show JAK2 ELISA Kits), and STAT1 (show STAT1 ELISA Kits)/STAT3 proteins in bovine articular chondrocytes
peroxynitrite causes increased expression of VEGF (show VEGFA ELISA Kits) in vascular endothelial cells by a process that requires the activation of STAT3
Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (show NOX1 ELISA Kits)-mediated activation of STAT3.
this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (show CCND2 ELISA Kits) and PSEN1 (show PSEN1 ELISA Kits) genes via a STAT3-dependent pathway
Studied effect of recombinant porcine leukemia inhibitory factor (show LIF ELISA Kits) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (show FTH1 ELISA Kits)-supplemented media.
Data suggest that IL-6 (interleukin 6 (show IL6 ELISA Kits)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (show IL6 ELISA Kits)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).
the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.
Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.
STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways
Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.
This is the first report of the genetic polymorphisms of the JAK1 (show JAK1 ELISA Kits) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.
Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.
Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (show MMP2 ELISA Kits) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.
Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a (show CDC25A ELISA Kits) expression during oogenesis. Accordingly, restoring Cdc25a (show CDC25A ELISA Kits) expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.
PTPN9 (show PTPN9 ELISA Kits) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (show GATA1 ELISA Kits) and ZBP-89 (show ZNF148 ELISA Kits).
Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.
Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.
This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.
The results of this study suggested that the stat3/socs3 (show SOCS3 ELISA Kits) pathway is a key response in all tissue regeneration in zebrafish.
stat3, a known oncogene (show RAB1A ELISA Kits) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.
Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (show PRCP ELISA Kits) in neighboring cells during zebrafish gastrulation.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 3 (acute-phase response factor)
, signal transducer and activator of transcription 3
, signal transduction and activation of transcription 3
, Signal transducer and activator of transcription 3
, signal transducer and activator of transcription 3-like
, acute phase response factor
, acute-phase response factor
, DNA-binding protein APRF
, Protein Stat3
, signal transducer and activator of transcription 3.1
, stat 3