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Browse our STAT3 Proteins (STAT3)

Full name:
Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) Proteins (STAT3)
On www.antibodies-online.com are 25 Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Proteins from 10 different suppliers available. Additionally we are shipping STAT3 Antibodies (614) and STAT3 Kits (49) and many more products for this protein. A total of 717 STAT3 products are currently listed.
Synonyms:
1110034C02Rik, aprf, AW109958, hies, stat3, wu:fc15d02, wu:fl59g06, Xstat3, z-Stat3
list all proteins Gene Name GeneID UniProt
STAT3 20848 P42227
STAT3 6774 P40763
STAT3 25125 P52631

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STAT3 Proteins (STAT3) by Origin

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Top referenced STAT3 Proteins

  1. Human STAT3 Protein expressed in Wheat germ - ABIN1321594 : Qian, Chai, Liang, Wang, Zhou, Xu, Zhang, Zhang, Si, Huang, Huang, Hong, Wang: KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer. in Molecular cancer 2014 (PubMed)
    Show all 2 references for ABIN1321594

More Proteins for STAT3 Interaction Partners

Mouse (Murine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. fad104 suppressed anchorage-independent growth of melanoma cells, and the N-terminal region of FAD104 is essential for inhibiting malignant transformation and STAT3 activity

  2. The data demonstrated that boldine may be beneficial in colitis through selective immunomodulatory effects, which may be mediated, at least in part, by inhibition of p65-NF-kappaB (show NFkBP65 Proteins) and STAT3 signaling pathways

  3. Study showed that suppression of STAT3, STAT5 (show STAT5A Proteins), and STAT6 (show STAT6 Proteins) and overexpression of the proapoptotic factor STAT1 (show STAT1 Proteins), which provides p53 (show TP53 Proteins)-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 (show ERBB2 Proteins) tyrosine kinase receptor (show KDR Proteins) overexpression promotes neuronal survival through activation of STAT (show STAT1 Proteins)-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1 (show STAT1 Proteins)

  4. inflammatory cytokine insults stimulate epithelial-to-mesenchymal transition (EMT (show ITK Proteins)) as well as the endocrine program in human pancreatic ductal cells via STAT3-dependent NGN3 (show NEUROG3 Proteins) activation.

  5. Study provides evidence for new immunoregulatory mechanisms of STAT3 during intestinal inflammation.

  6. IL-6 (show IL6 Proteins)/P-STAT3 activation influences p63 (show CKAP4 Proteins) isoform expression in healing wounds, which may contribute to wound-induced hair follicle neogenesis.

  7. IL6 (show IL6 Proteins)/STAT3 signalling dysregulation, caused by IL6 (show IL6 Proteins) deficiency, resulted in skewing of the immune modulatory properties of mesenchymal stem cells to favour a pro-inflammatory profile.

  8. These results highlight central nervous system neuronal dependence on STAT3 transcriptional activity.

  9. Our results suggest a protective function of HO-1 induction in psoriasis. The protective effect of HO-1 may be attributed to its effect on the Stat3 signaling pathway via increased SHP-1 expression.

  10. STAT3/Arid1b/beta-catenin (show CTNNB1 Proteins) pathway is driving neurofibroma initiation.

Human Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. MCT1 (show CMA1 Proteins) expression associates with the SCC (show CYP11A1 Proteins) type and metastatic behavior of AC, whereas MCT4 (show SLC16A4 Proteins) expression concomitantly increases from in situ SCC (show CYP11A1 Proteins) to invasive SCC (show CYP11A1 Proteins) and is significantly associated with the AC type. Consistently, FOXM1 (show FOXM1 Proteins) expression is statistically associated with MCT1 (show CMA1 Proteins) positivity in SCC (show CYP11A1 Proteins), whereas the expression of FOXO3a (show FOXO3 Proteins), a FOXM1 (show FOXM1 Proteins) functional antagonist, is linked to MCT1 (show CMA1 Proteins) negativity

  2. MiR (show MLXIP Proteins)-129-5p may directly inhibit STAT3 expression.

  3. Together, these results suggest that the IL-11 (show IL11 Proteins)/STAT3 signaling pathway plays a critical role in human chronic atrophic gastritis , and may provide new targets to prevent and treat gastric cancer

  4. Metformin targets STAT3/NFkappaB signaling to inhibit proliferation/invasiveness of cholangiocarcinoma cells.

  5. Valosin-containing protein (VCP (show vcp Proteins)) promotes the growth, invasion, and metastasis of colorectal cancer through activation of STAT3 signaling.

  6. fad104 suppressed anchorage-independent growth of melanoma cells, and the N-terminal region of FAD104 is essential for inhibiting malignant transformation and STAT3 activity

  7. We determined that IL-17A-induced VEGF upregulation and neovascularization through a Stat3-mediated signaling pathway and hypothesized that blocking the Stat3 activation by using JSI-124, an inhibitor of phosphorylated Stat3, could significantly reduce the VEGF expression and can thus prevent angiogenesis

  8. HCV NS4B contributed to hepatocellular carcinoma by activating the endoplasmic reticulum stress-mediated cancer-related STAT3 pathway.

  9. inflammatory cytokine insults stimulate epithelial-to-mesenchymal transition (EMT (show ITK Proteins)) as well as the endocrine program in human pancreatic ductal cells via STAT3-dependent NGN3 (show NEUROG3 Proteins) activation.

  10. The protein expression of active caspase-3 (show CASP3 Proteins) increased with STAT3 siRNA treatment, and was significantly higher than that of the control group (P < 0.05). STAT3 gene-silencing significantly improves the apoptotic effect against Bel (show LHX2 Proteins)-7402 cells.

Cow (Bovine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.

  2. Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate

  3. results show for the first time that interleukin-6 (show IL6 Proteins) (IL), in the presence of its soluble receptor (show IFNAR1 Proteins) (sIL-6R), induces activation of JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and STAT1 (show STAT1 Proteins)/STAT3 proteins in bovine articular chondrocytes

  4. peroxynitrite causes increased expression of VEGF (show VEGFA Proteins) in vascular endothelial cells by a process that requires the activation of STAT3

  5. Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (show NOX1 Proteins)-mediated activation of STAT3.

Pig (Porcine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (show CCND2 Proteins) and PSEN1 (show PSEN1 Proteins) genes via a STAT3-dependent pathway

  2. Studied effect of recombinant porcine leukemia inhibitory factor (show LIF Proteins) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (show FTH1 Proteins)-supplemented media.

  3. Data suggest that IL-6 (interleukin 6 (show IL6 Proteins)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (show IL6 Proteins)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).

  4. the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.

  5. Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.

  6. STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways

  7. Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.

Rabbit Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. This is the first report of the genetic polymorphisms of the JAK1 (show JAK1 Proteins) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.

Guinea Pig Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.

  2. Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (show MMP2 Proteins) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.

Zebrafish Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. PTPN9 (show PTPN9 Proteins) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (show GATA1 Proteins) and ZBP-89 (show ZNF148 Proteins).

  2. Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.

  3. Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.

  4. This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.

  5. The results of this study suggested that the stat3/socs3 (show SOCS3 Proteins) pathway is a key response in all tissue regeneration in zebrafish.

  6. stat3, a known oncogene (show RAB1A Proteins) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.

  7. Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (show PRCP Proteins) in neighboring cells during zebrafish gastrulation.

STAT3 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with STAT3

  • signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3)
  • signal transduction and activation of transcription 3 (stat3)
  • signal transducer and activator of transcription 3 (acute-phase response factor) (stat3)
  • signal transducer and activator of transcription 3 (Stat3)
  • signal transducer and activator of transcription 3 (acute-phase response factor) (Stat3)
  • signal transducer and activator of transcription 3 (acute-phase response factor), gene 1 (stat3.1)
  • 1110034C02Rik protein
  • aprf protein
  • AW109958 protein
  • hies protein
  • stat3 protein
  • wu:fc15d02 protein
  • wu:fl59g06 protein
  • Xstat3 protein
  • z-Stat3 protein

Protein level used designations for STAT3

signal transducer and activator of transcription 3 (acute-phase response factor) , signal transducer and activator of transcription 3 , signal transduction and activation of transcription 3 , Signal transducer and activator of transcription 3 , signal transducer and activator of transcription 3-like , acute phase response factor , acute-phase response factor , DNA-binding protein APRF , Protein Stat3 , signal transducer and activator of transcription 3.1 , stat 3

GENE ID SPECIES
100011382 Monodelphis domestica
100171541 Pongo abelii
100380714 Salmo salar
100469938 Ailuropoda melanoleuca
100566559 Anolis carolinensis
100598877 Nomascus leucogenys
20848 Mus musculus
6774 Homo sapiens
25125 Rattus norvegicus
490967 Canis lupus familiaris
508541 Bos taurus
733648 Sus scrofa
420027 Gallus gallus
574128 Macaca mulatta
454682 Pan troglodytes
100348778 Oryctolagus cuniculus
100717084 Cavia porcellus
100294659 Ovis aries
779100 Xenopus laevis
30767 Danio rerio
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