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Human STAT3 Protein expressed in Wheat germ - ABIN1321594
Qian, Chai, Liang, Wang, Zhou, Xu, Zhang, Zhang, Si, Huang, Huang, Hong, Wang: KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer. in Molecular cancer 2014
Show all 2 references for ABIN1321594
These results establish that Bcl3 (show BCL3 Proteins) positively regulates pluripotency genes and thus shed light on the mechanism of Bcl3 (show BCL3 Proteins) as a downstream molecule of LIF (show LIF Proteins)/STAT3 signaling in pluripotency maintenance.
Epo (show EPO Proteins) regulates hypothalamus POMC (show POMC Proteins) expression via STAT3 activation.
Findings suggest that isoflurane-induced neurotoxicity may stem from signal transducer and activator of transcription (show STAT1 Proteins)- degradation, partially through the activation of calcineurin (show PPP3CA Proteins).
Antisense oligonucleotide AZD9150 decreased STAT3 expression in a broad range of preclinical cancer models and showed antitumor activity in lymphoma and lung cancer models.
STAT1 (show STAT1 Proteins) deficiency reprograms IFN signaling from priming toward suppression of TLR response via feedback regulation of STAT3.
These data support a role of pSTAT3 in TLR4 (show TLR4 Proteins) dependent Abdominal Aortic Aneurysm (AAA (show AAAS Proteins)) formation and possible therapeutic roles for TLR4 (show TLR4 Proteins) and/or STAT3 inhibition in AAA (show AAAS Proteins)
the expression changes observed within the BCL2 (show BCL2 Proteins) family did not depend on STAT3 signalling, in line with its initiating role early in the process, but rather appear to result from relief of repression by STAT5 (show STAT5A Proteins).
Sphingosylphosphorylcholine promotes the differentiation of resident Sca-1 positive cardiac stem cells to cardiomyocytes through lipid raft/JNK (show MAPK8 Proteins)/STAT3 and beta-catenin (show CTNNB1 Proteins) signaling pathways.
CCR5 blockade suppresses B16 melanoma growth by inhibiting of IL-6 (show IL6 Proteins)-Stat3 signaling pathway via upregulation of SOCS3 (show SOCS3 Proteins).
neuronal and astroglial STAT3 molecules are involved in the pathways underlying cell death
The STAT3-Ser (show SIGLEC1 Proteins)/Hes3 (show HES3 Proteins) Signaling Axis was first identified as a major regulator of neural stem cells and, subsequently, cancer stem cells
our data suggest that SIRT6 (show SIRT6 Proteins) suppresses glioma cell growth via induction of apoptosis, inhibition of oxidative stress and inhibition of the activation of the JAK2 (show JAK2 Proteins)/STAT3 signaling pathway.
this study shows that miR (show MLXIP Proteins)-124-3p may negatively regulate the transcription of the STAT3 by interfering with its 3'UTR, and the degradation of STAT3 affects its downstream expression of such as p-STAT3, CCND2 (show CCND2 Proteins) and MMP-2 (show MMP2 Proteins)
Our data suggested that IL-6 (show IL6 Proteins) mediates the singnal pathway of JAK (show JAK3 Proteins)-STAT3-VEGF-C (show VEGFC Proteins) promoting the growth, invasion and lymphangiogenesis in gastric cancer
Treatment of isolinderalactone increased the protein level of SCOS3, decreased phosphorylation of the STAT3 and suppressed expression of the down-stream genes of the X-linked inhibitor of apoptosis protein (show XIAP Proteins)
The rs4796793 STAT3 genotype is a novel predictive factor for response to multiple tyrosine kinase (show TXK Proteins) inhibitors in metastatic renal cell carcinoma (show MOK Proteins).
the STAT3 mutations found in the patient cohort were concluded to be deleterious for normal STAT3 function.
Our data indicated that Eag1 promotes osteosarcoma proliferation and migration, at least in part, by targeting STAT3-VEGF pathway.
STAT3 is a direct target of miR (show MLXIP Proteins)-506. STAT3 mRNA expression was increased in glioma and inversely correlated with miR (show MLXIP Proteins)-506. Its overexpression attenuated the suppressive effects of miR (show MLXIP Proteins)-506 on cell proliferation, colony formation, migration and invasion.
The present study finds that the aspirin-FOXD3 (show FOXD3 Proteins)-OLA1P2-STAT3 axis exhibits exciting anticancer effects and provides new insights into the chemopreventive mechanisms underlying aspirin use
STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.
Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate
results show for the first time that interleukin-6 (show IL6 Proteins) (IL), in the presence of its soluble receptor (show IFNAR1 Proteins) (sIL-6R), induces activation of JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and STAT1 (show STAT1 Proteins)/STAT3 proteins in bovine articular chondrocytes
peroxynitrite causes increased expression of VEGF (show VEGFA Proteins) in vascular endothelial cells by a process that requires the activation of STAT3
Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (show NOX1 Proteins)-mediated activation of STAT3.
Studied effect of recombinant porcine leukemia inhibitory factor (show LIF Proteins) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (show FTH1 Proteins)-supplemented media.
Data suggest that IL-6 (interleukin 6 (show IL6 Proteins)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (show IL6 Proteins)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).
the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.
Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.
STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways
Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.
This is the first report of the genetic polymorphisms of the JAK1 (show JAK1 Proteins) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.
Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.
Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (show MMP2 Proteins) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.
PTPN9 (show PTPN9 Proteins) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (show GATA1 Proteins) and ZBP-89 (show ZNF148 Proteins).
Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.
Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.
This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.
The results of this study suggested that the stat3/socs3 (show SOCS3 Proteins) pathway is a key response in all tissue regeneration in zebrafish.
stat3, a known oncogene (show RAB1A Proteins) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.
Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (show PRCP Proteins) in neighboring cells during zebrafish gastrulation.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 3 (acute-phase response factor)
, signal transducer and activator of transcription 3
, signal transduction and activation of transcription 3
, Signal transducer and activator of transcription 3
, signal transducer and activator of transcription 3-like
, acute phase response factor
, acute-phase response factor
, DNA-binding protein APRF
, Protein Stat3
, signal transducer and activator of transcription 3.1
, stat 3