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Human STAT3 Protein expressed in Wheat germ - ABIN1321594
Qian, Chai, Liang, Wang, Zhou, Xu, Zhang, Zhang, Si, Huang, Huang, Hong, Wang: KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer. in Molecular cancer 2014
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ginsenoside Rb2 (show RBL2 Proteins) inhibits osteoclast differentiation by blocking NF-kappaB (show NFKB1 Proteins) and STAT3 signaling pathways.
The activation of STAT3 was much higher in Gal12 (show LGALS12 Proteins)(-/-) macrophages activated by lipopolysaccharide, which was correlated with higher levels of IL-10 (show IL10 Proteins). Adipocytes showed higher insulin (show INS Proteins) sensitivity when treated with Gal12 (show LGALS12 Proteins)(-/-) macrophage-conditioned media than those treated with Gal12 (show LGALS12 Proteins)(+/+) macrophages.
After Dox treatment, the protein expression of p-Jak2 (show JAK2 Proteins) and p-Stat3 levels was significantly increased in MT(+/+) cardiomyocytes, suggesting that the JAK2 (show JAK2 Proteins)/STAT3 pathway was partially involved in MT protection against Dox-induced cardiotoxicity
Studied effect of Coptis Chinensis on glioma cells; results showed Coptis Chinensis induced cell cycle arrest and apoptosis in glioma cells, down-regulated the signal transducer and activator oftranscription 3 (STAT3) phosphorylation levels, and reduced the expression of histone deacetylase 3 (HDAC3 (show HDAC3 Proteins)).
M1 macrophages with inhibited STAT3, STAT6 (show STAT6 Proteins) and/or SMAD3 (show SMAD3 Proteins) effectively restrict tumor growth. The findings justify the development of new anti-tumor cell therapy technology.
Our data suggest that the inhibition of sRAGE on I/R-induced apoptosis is associated with activation and expression of proteasome, including improved proteasome activity and elevated beta1i (show PSMB9 Proteins) and beta5i expression mediated by STAT3 activation. We predict that sRAGE is a novel intervention to target UPS activation for preventing and treating myocardial apoptosis.
our data indicate that luteolin diminishes the proinflammatory mediators NO, inflammatory cytokines and the expression of their regulatory genes, iNOS (show NOS2 Proteins) and COX-2, in PRV-infected RAW264.7 cells by inhibiting STAT1 (show STAT1 Proteins)/3 dependent NF-kappaB (show NFKB1 Proteins) activation and inducing Nrf2mediated HO-1 (show HMOX1 Proteins) expression.
activation of beta2-AR accelerated hepatocyte proliferation and improved recellularized liver function by mediating the IL-6 (show IL6 Proteins)/Stat 3 signalling pathway, indicating that nervous system regulation may be an essential component contributing to the complexity of recellularized liver in tissue engineering
Stat3 mediates the expression of iNOS (show NOS2 Proteins) to promote IFNgamma/TNFalpha (show TNF Proteins)-induced muscle atrophy.
BMI1 (show BMI1 Proteins) and MEL18 (show PCGF2 Proteins) contribute to the development of colitis-associated cancer in mice by promoting proliferation and reducing apoptosis via suppressing expression of Reg3b. REG3B negatively regulates cytokine-induced activation of STAT3 in colon epithelial cells.
G-rich sequences in the STAT3 gene could form G-quadruplexes under near physiological conditions.
nuclear localization of pSTAT3 in leukemic cells may have a role in hematopoietic stem cell transplant-associated large granular lymphocytic leukemia
CD36 (show CD36 Proteins)/STAT3 SNPs linked to cardiovascular disease may modulate the effects of different diets on biochemical and inflammatory markers among these subjects.
Acquired lapatinib-resistant HER2 (show ERBB2 Proteins)-positive breast cancer cells had elevated IL-6 (show IL6 Proteins), and that elevated IL-6 (show IL6 Proteins) maintained the stemness population and property within these resistant cells through the activation of STAT3.
STAT3/STAT1 (show STAT1 Proteins) ratios are better clinical predictors in Colorectal carcinoma as compared to STAT3 or STAT1 (show STAT1 Proteins) levels alone.
Multilayer OMIC data analysis uncovered methylation hallmarks in genetically defined Medullary thyroid carcinoma (MTC (show MT1A Proteins)) and revealed JAK (show JAK3 Proteins)/Stat (show STAT1 Proteins) signaling effector STAT3 as a potential therapeutic target for the treatment of RET (show RET Proteins)(M918T) MTCs
Suggest a positive feedback mechanism via the STAT1 (show STAT1 Proteins)/3 pathway sustains cytokine production and reveal a reciprocal regulatory role of JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) in TNFalpha (show TNF Proteins)-mediated senescence.
the EGFR (show EGFR Proteins)/STAT3 pathway contributed to CDDP-induced CEBPD (show CEBPD Proteins) expression in UCUB cells. Gefitinib and S3I-201 treatment significantly reduced the expression of CEBPD (show CEBPD Proteins) and enhanced the sensitivity of CDDP-resistant UCUB cells to CDDP and paclitaxel
Primary open angle glaucoma in type 2 diabetes: Implications of the IL-10 (show IL10 Proteins)/STAT3-mediated anti-inflammatory response
Our study supports the development of strategies targeting STAT3 inhibition in combination with conventional chemotherapy for patients with high-risk neuroblastoma (show ARHGEF16 Proteins)
STA3 (show ARHGEF3 Proteins) facilitates TLR4 (show TLR4 Proteins)-dependent IL-6 (show IL6 Proteins) and IL-8 (show IL8 Proteins) production via IL-6 (show IL6 Proteins) receptor-positive feedback in endometrial cells.
STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.
Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate
results show for the first time that interleukin-6 (show IL6 Proteins) (IL), in the presence of its soluble receptor (show IFNAR1 Proteins) (sIL-6R), induces activation of JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and STAT1 (show STAT1 Proteins)/STAT3 proteins in bovine articular chondrocytes
peroxynitrite causes increased expression of VEGF (show VEGFA Proteins) in vascular endothelial cells by a process that requires the activation of STAT3
Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (show NOX1 Proteins)-mediated activation of STAT3.
this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (show CCND2 Proteins) and PSEN1 (show PSEN1 Proteins) genes via a STAT3-dependent pathway
Studied effect of recombinant porcine leukemia inhibitory factor (show LIF Proteins) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (show FTH1 Proteins)-supplemented media.
Data suggest that IL-6 (interleukin 6 (show IL6 Proteins)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (show IL6 Proteins)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).
the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.
Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.
STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways
Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.
This is the first report of the genetic polymorphisms of the JAK1 (show JAK1 Proteins) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.
Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.
Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (show MMP2 Proteins) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.
Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a (show CDC25A Proteins) expression during oogenesis. Accordingly, restoring Cdc25a (show CDC25A Proteins) expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.
PTPN9 (show PTPN9 Proteins) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (show GATA1 Proteins) and ZBP-89 (show ZNF148 Proteins).
Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.
Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.
This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.
The results of this study suggested that the stat3/socs3 (show SOCS3 Proteins) pathway is a key response in all tissue regeneration in zebrafish.
stat3, a known oncogene (show RAB1A Proteins) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.
Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (show PRCP Proteins) in neighboring cells during zebrafish gastrulation.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 3 (acute-phase response factor)
, signal transducer and activator of transcription 3
, signal transduction and activation of transcription 3
, Signal transducer and activator of transcription 3
, signal transducer and activator of transcription 3-like
, acute phase response factor
, acute-phase response factor
, DNA-binding protein APRF
, Protein Stat3
, signal transducer and activator of transcription 3.1
, stat 3