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Browse our STAT3 Proteins (STAT3)

Full name:
Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) Proteins (STAT3)
On www.antibodies-online.com are 34 Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Proteins from 10 different suppliers available. Additionally we are shipping STAT3 Antibodies (604) and STAT3 Kits (56) and many more products for this protein. A total of 721 STAT3 products are currently listed.
Synonyms:
1110034C02Rik, aprf, AW109958, hies, stat3, wu:fc15d02, wu:fl59g06, Xstat3, z-Stat3
list all proteins Gene Name GeneID UniProt
STAT3 20848 P42227
STAT3 6774 P40763
STAT3 25125 P52631

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STAT3 Proteins (STAT3) by Origin

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Top referenced STAT3 Proteins

  1. Human STAT3 Protein expressed in Wheat germ - ABIN1321594 : Qian, Chai, Liang, Wang, Zhou, Xu, Zhang, Zhang, Si, Huang, Huang, Hong, Wang: KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer. in Molecular cancer 2014 (PubMed)
    Show all 2 references for ABIN1321594

More Proteins for STAT3 Interaction Partners

Mouse (Murine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. Stat3 plays a compensatory anti-apoptotic role in IL-17A (show IL17A Proteins)/iNOS (show NOS2 Proteins)-mediated cardiomyocyte apoptosis via inhibiting iNOS (show NOS2 Proteins) transcription, providing a novel molecular mechanism of apoptosis regulation and complicated interactions between IL-17A (show IL17A Proteins)/iNOS (show NOS2 Proteins) and IL-17A (show IL17A Proteins)/Stat3 signalings.

  2. STAT3-dependent transcriptional activity regulates critical components for the architecture and functional dynamics of endothelial junctions, thus permitting vascular permeability.

  3. The production of inflammatory mediators of IL-6 (show IL6 Proteins) and COX-2 was also significantly attenuated when treated with 1. It may be attributed to inhibiting NFkappaB signaling. Moreover, this polyphenol suppressed p-STAT3 production as well as its downstream proteins response for apoptosis, such as Bcl-2 (show BCL2 Proteins) and Bax (show BAX Proteins). In summary, the study not only afforded our understanding involved in colitis, but also provided the possible thera...

  4. Following an acute infection, murine gammaherpesvirus 68 (MHV68) established latency in resident B cells, but establishment of latency was dramatically reduced in animals with a B cell-specific STAT3 deletion.

  5. adiponectin (show ADIPOQ Proteins) maintains intestinal homeostasis and protects against murine colitis through interactions with its receptor AdipoR1 (show ADIPOR1 Proteins) and by modulating adaptive immunity and STAT3 signaling

  6. lipopolysaccharides induces STAT3 activation in macrophages.

  7. we showed that Stat3 is activated in cartilage from joint subjected to destabilisation of the medial meniscus and appears as the main signalling pathway involved in IL-6 (show IL6 Proteins)-induced cartilage breakdown.

  8. STAT3 and HMGA2 cooperatively promote adipogenesis which shows that the STAT3 related transcription factor is involved in adipogenesis

  9. STAT3 may cooperate with AhR (show AHR Proteins) to regulate the differentiation of both Th17 and Treg cells

  10. These exosomes promoted the growth of myeloid-derived suppressor cells (MDSCs) in naive mice through activation of the STAT3 pathway and changed their subsets to similar phenotypes to those seen in Multiple myeloma (MM)-bearing mice.

Human Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. findings suggest that EZH2 (show EZH2 Proteins) possesses anti-apoptotic activity in gastric tumorigenesis following STAT3 activation

  2. data demonstrated that Tipalpha may accelerate tumor aggressiveness in gastric cancer by promoting EMT (show ITK Proteins) through activation of IL-6 (show IL6 Proteins)/STAT3 pathway

  3. miR (show MLXIP Proteins)-124 is a novel regulator of invasiveness and tumorigenicity in glioblastoma cells by targeting STAT3.

  4. The balance between IL-2 (show IL2 Proteins)-induced STAT5 (show STAT5A Proteins) activation, regulated by TCR signaling, and STAT3 activation, regulated by pro-Th17 cytokines, is likely to be critical in determining the level of Th17 polarization.

  5. mRNA expression levels of 1279 genes were found to be associated with phosphorylated STAT3(705) expression.

  6. When STAT3 levels were sufficiently high, STAT3 no longer protected chronic lymphocytic leukemia (CLL) cells from apoptosis. Instead, STAT3 induced the expression of proapoptotic genes, activated the caspase-3 (show CASP3 Proteins) gene promoter, and induced apoptosis in CLL cells.

  7. RNA and protein expressions of NF-kappaB (show NFKB1 Proteins) and STAT3 increased significantly in thyroid carcinoma tissues.

  8. signal transducer and activator of transcription (Stat (show STAT1 Proteins))3 represses Smad3 (show SMAD3 Proteins) in synergy with the potent negative regulators of TGF-beta (show TGFB1 Proteins) signaling, c-Ski (show SKI Proteins) and SnoN (show SKIL Proteins), whereby renders gefitinib-sensitive HCC827 cells resistant

  9. STAT3 and miR (show MLXIP Proteins)-181b control each other's expression in a positive feedback loop that regulates SFCs via CYLD (show CYLD Proteins) pathway.

  10. STAT3-dependent transcriptional activity regulates critical components for the architecture and functional dynamics of endothelial junctions, thus permitting vascular permeability.

Cow (Bovine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.

  2. Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate

  3. results show for the first time that interleukin-6 (show IL6 Proteins) (IL), in the presence of its soluble receptor (show IFNAR1 Proteins) (sIL-6R), induces activation of JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and STAT1 (show STAT1 Proteins)/STAT3 proteins in bovine articular chondrocytes

  4. peroxynitrite causes increased expression of VEGF (show VEGFA Proteins) in vascular endothelial cells by a process that requires the activation of STAT3

  5. Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (show NOX1 Proteins)-mediated activation of STAT3.

Pig (Porcine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets

  2. maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (show CCND2 Proteins) and PSEN1 (show PSEN1 Proteins) genes via a STAT3-dependent pathway

  3. Studied effect of recombinant porcine leukemia inhibitory factor (show LIF Proteins) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (show FTH1 Proteins)-supplemented media.

  4. Data suggest that IL-6 (interleukin 6 (show IL6 Proteins)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (show IL6 Proteins)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).

  5. the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.

  6. Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.

  7. STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways

  8. Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.

Rabbit Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. This is the first report of the genetic polymorphisms of the JAK1 (show JAK1 Proteins) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.

Guinea Pig Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.

  2. Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (show MMP2 Proteins) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.

Zebrafish Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) interaction partners

  1. Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a (show CDC25A Proteins) expression during oogenesis. Accordingly, restoring Cdc25a (show CDC25A Proteins) expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.

  2. PTPN9 (show PTPN9 Proteins) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (show GATA1 Proteins) and ZBP-89 (show ZNF148 Proteins).

  3. Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.

  4. Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.

  5. This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.

  6. The results of this study suggested that the stat3/socs3 (show SOCS3 Proteins) pathway is a key response in all tissue regeneration in zebrafish.

  7. stat3, a known oncogene (show RAB1A Proteins) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.

  8. Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (show PRCP Proteins) in neighboring cells during zebrafish gastrulation.

STAT3 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with STAT3

  • signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3)
  • signal transduction and activation of transcription 3 (stat3)
  • signal transducer and activator of transcription 3 (acute-phase response factor) (stat3)
  • signal transducer and activator of transcription 3 (Stat3)
  • signal transducer and activator of transcription 3 (acute-phase response factor) (Stat3)
  • signal transducer and activator of transcription 3 (acute-phase response factor), gene 1 (stat3.1)
  • 1110034C02Rik protein
  • aprf protein
  • AW109958 protein
  • hies protein
  • stat3 protein
  • wu:fc15d02 protein
  • wu:fl59g06 protein
  • Xstat3 protein
  • z-Stat3 protein

Protein level used designations for STAT3

signal transducer and activator of transcription 3 (acute-phase response factor) , signal transducer and activator of transcription 3 , signal transduction and activation of transcription 3 , Signal transducer and activator of transcription 3 , signal transducer and activator of transcription 3-like , acute phase response factor , acute-phase response factor , DNA-binding protein APRF , Protein Stat3 , signal transducer and activator of transcription 3.1 , stat 3

GENE ID SPECIES
100011382 Monodelphis domestica
100171541 Pongo abelii
100380714 Salmo salar
100469938 Ailuropoda melanoleuca
100566559 Anolis carolinensis
100598877 Nomascus leucogenys
20848 Mus musculus
6774 Homo sapiens
25125 Rattus norvegicus
490967 Canis lupus familiaris
508541 Bos taurus
733648 Sus scrofa
420027 Gallus gallus
574128 Macaca mulatta
454682 Pan troglodytes
100348778 Oryctolagus cuniculus
100717084 Cavia porcellus
100294659 Ovis aries
779100 Xenopus laevis
30767 Danio rerio
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