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Human STAT3 Primary Antibody for AP, AA - ABIN1321594
Qian, Chai, Liang, Wang, Zhou, Xu, Zhang, Zhang, Si, Huang, Huang, Hong, Wang: KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer. in Molecular cancer 2014
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This study demonstrated that Hyperactivated Stat3 boosts axon regeneration in the peripheral nervous system regeneration can promote axon regeneration in the central nervous system.
STAT3 protects repair Schwann cells from death and contributes to maintaining the molecular and morphological repair phenotype that promotes axonal regeneration.
this study shows that resokaempferol inhibits the inflammatory response in activated macrophages by blocking the activation of the STAT3 pathway
this paper shows that isocyperol mediates its anti-inflammatory activity via suppression of the STAT3 pathway
this study shows that downregulation of Stat3 in dendritic cells by paeoniflorin is mediated via upregulation of Socs3 (show SOCS3 Proteins)
this study shows that IL-22 (show IL22 Proteins) plays role in acute graft versus host disease via IL-22R (show IL22RA1 Proteins)-STAT3 pathway
this study shows that Le Carbone, a charcoal supplement, attenuates experimental colitis through downregulation of STAT3
Data show that interleukin-1 receptor-associated kinase 3 (IRAK-M (show IRAK3 Proteins)) is responsible for regulation of microbial colonization of tumors and STAT3 protein stability in tumor cells, leading to tumor cell proliferation.
Hippocampal neuronal maturation was enhanced when Stat3 was downregulated.
Data show that Tripterygium wilfordii Hook. f.(GTW) suppressed Th17 function through the inhibition of signal transducer and activator of transcription 3 (STAT3) phosphorylation.
High STAT3 or phospho-STAT3 expression is a strong predictor of poor prognosis among patients with NSCLC.
Taken together, these findings suggested that E2 inhibited the proliferation of AR HCC (show FAM126A Proteins) cells through down-regulation of IL-6 (show IL6 Proteins)/STAT3 signaling. Thus, E2 can be a potential therapeutic drug for treatment of metastatic or chemo-resistant HCC (show FAM126A Proteins).
a JAK2 (show JAK2 Proteins) Inhibitor Suppresses a BCL6 (show BCL6 Proteins)-dependent IL10RA (show IL10RA Proteins)/JAK2 (show JAK2 Proteins)/STAT3 Pathway in High Grade B-cell Lymphoma.
Collectively, our results demonstrate that the STAT3(K392R) mutation causes premature endocrine differentiation through direct induction of NEUROG3 (show NEUROG3 Proteins) expression.
this study shows that Hepatitis C virus-induced myeloid-derived suppressor cells promote regulatory T cell development and inhibit effector T cell function via the STAT3 pathway, representing a novel mechanism for T-cell regulation during viral infection
STAT-1 (show STAT1 Proteins), STAT-3, and STAT (show STAT1 Proteins)-5b expression was also enhanced after IL-21 (show IL17C Proteins) treatment, with STAT-3 being the most significantly enhanced
Upregulation of STAT3 is associated with breast cancer.
Shp2 (show PTPN11 Proteins) (Src (show SRC Proteins)-homology 2 domain-containing phosphatase 2) functions as a negative regulator for STAT3 transcription factor (Stat3) activation in esophageal squamous cell cancer (ESCC).
Icaritin significantly inhibited the expression of phospho-signal transducer and activator of transcription 3 (p-STAT3) in a dose- and time-dependent manner.
Significantly suppresses the p-STAT3 expression and its downstream genes including CCL2 (show CCL2 Proteins) and Bcl2 (show BCL2 Proteins).
STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.
Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate
results show for the first time that interleukin-6 (show IL6 Proteins) (IL), in the presence of its soluble receptor (show IFNAR1 Proteins) (sIL-6R), induces activation of JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and STAT1 (show STAT1 Proteins)/STAT3 proteins in bovine articular chondrocytes
peroxynitrite causes increased expression of VEGF (show VEGFA Proteins) in vascular endothelial cells by a process that requires the activation of STAT3
Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (show NOX1 Proteins)-mediated activation of STAT3.
this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (show CCND2 Proteins) and PSEN1 (show PSEN1 Proteins) genes via a STAT3-dependent pathway
Studied effect of recombinant porcine leukemia inhibitory factor (show LIF Proteins) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (show FTH1 Proteins)-supplemented media.
Data suggest that IL-6 (interleukin 6 (show IL6 Proteins)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (show IL6 Proteins)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).
the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.
Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.
STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways
Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.
This is the first report of the genetic polymorphisms of the JAK1 (show JAK1 Proteins) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.
Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.
Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (show MMP2 Proteins) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.
PTPN9 (show PTPN9 Proteins) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (show GATA1 Proteins) and ZBP-89 (show ZNF148 Proteins).
Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.
Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.
This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.
The results of this study suggested that the stat3/socs3 (show SOCS3 Proteins) pathway is a key response in all tissue regeneration in zebrafish.
stat3, a known oncogene (show RAB1A Proteins) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.
Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (show PRCP Proteins) in neighboring cells during zebrafish gastrulation.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 3 (acute-phase response factor)
, signal transducer and activator of transcription 3
, signal transduction and activation of transcription 3
, Signal transducer and activator of transcription 3
, signal transducer and activator of transcription 3-like
, acute phase response factor
, acute-phase response factor
, DNA-binding protein APRF
, Protein Stat3
, signal transducer and activator of transcription 3.1
, stat 3