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Human STAT3 Protein expressed in Wheat germ - ABIN1321594
Qian, Chai, Liang, Wang, Zhou, Xu, Zhang, Zhang, Si, Huang, Huang, Hong, Wang: KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer. in Molecular cancer 2014
Show all 2 references for ABIN1321594
fad104 suppressed anchorage-independent growth of melanoma cells, and the N-terminal region of FAD104 is essential for inhibiting malignant transformation and STAT3 activity
The data demonstrated that boldine may be beneficial in colitis through selective immunomodulatory effects, which may be mediated, at least in part, by inhibition of p65-NF-kappaB (show NFkBP65 Proteins) and STAT3 signaling pathways
Study showed that suppression of STAT3, STAT5 (show STAT5A Proteins), and STAT6 (show STAT6 Proteins) and overexpression of the proapoptotic factor STAT1 (show STAT1 Proteins), which provides p53 (show TP53 Proteins)-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 (show ERBB2 Proteins) tyrosine kinase receptor (show KDR Proteins) overexpression promotes neuronal survival through activation of STAT (show STAT1 Proteins)-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1 (show STAT1 Proteins)
inflammatory cytokine insults stimulate epithelial-to-mesenchymal transition (EMT (show ITK Proteins)) as well as the endocrine program in human pancreatic ductal cells via STAT3-dependent NGN3 (show NEUROG3 Proteins) activation.
Study provides evidence for new immunoregulatory mechanisms of STAT3 during intestinal inflammation.
IL-6 (show IL6 Proteins)/P-STAT3 activation influences p63 (show CKAP4 Proteins) isoform expression in healing wounds, which may contribute to wound-induced hair follicle neogenesis.
IL6 (show IL6 Proteins)/STAT3 signalling dysregulation, caused by IL6 (show IL6 Proteins) deficiency, resulted in skewing of the immune modulatory properties of mesenchymal stem cells to favour a pro-inflammatory profile.
These results highlight central nervous system neuronal dependence on STAT3 transcriptional activity.
Our results suggest a protective function of HO-1 induction in psoriasis. The protective effect of HO-1 may be attributed to its effect on the Stat3 signaling pathway via increased SHP-1 expression.
STAT3/Arid1b/beta-catenin (show CTNNB1 Proteins) pathway is driving neurofibroma initiation.
MCT1 (show CMA1 Proteins) expression associates with the SCC (show CYP11A1 Proteins) type and metastatic behavior of AC, whereas MCT4 (show SLC16A4 Proteins) expression concomitantly increases from in situ SCC (show CYP11A1 Proteins) to invasive SCC (show CYP11A1 Proteins) and is significantly associated with the AC type. Consistently, FOXM1 (show FOXM1 Proteins) expression is statistically associated with MCT1 (show CMA1 Proteins) positivity in SCC (show CYP11A1 Proteins), whereas the expression of FOXO3a (show FOXO3 Proteins), a FOXM1 (show FOXM1 Proteins) functional antagonist, is linked to MCT1 (show CMA1 Proteins) negativity
MiR (show MLXIP Proteins)-129-5p may directly inhibit STAT3 expression.
Together, these results suggest that the IL-11 (show IL11 Proteins)/STAT3 signaling pathway plays a critical role in human chronic atrophic gastritis , and may provide new targets to prevent and treat gastric cancer
Metformin targets STAT3/NFkappaB signaling to inhibit proliferation/invasiveness of cholangiocarcinoma cells.
Valosin-containing protein (VCP (show vcp Proteins)) promotes the growth, invasion, and metastasis of colorectal cancer through activation of STAT3 signaling.
We determined that IL-17A-induced VEGF upregulation and neovascularization through a Stat3-mediated signaling pathway and hypothesized that blocking the Stat3 activation by using JSI-124, an inhibitor of phosphorylated Stat3, could significantly reduce the VEGF expression and can thus prevent angiogenesis
HCV NS4B contributed to hepatocellular carcinoma by activating the endoplasmic reticulum stress-mediated cancer-related STAT3 pathway.
The protein expression of active caspase-3 (show CASP3 Proteins) increased with STAT3 siRNA treatment, and was significantly higher than that of the control group (P < 0.05). STAT3 gene-silencing significantly improves the apoptotic effect against Bel (show LHX2 Proteins)-7402 cells.
STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.
Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate
results show for the first time that interleukin-6 (show IL6 Proteins) (IL), in the presence of its soluble receptor (show IFNAR1 Proteins) (sIL-6R), induces activation of JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and STAT1 (show STAT1 Proteins)/STAT3 proteins in bovine articular chondrocytes
peroxynitrite causes increased expression of VEGF (show VEGFA Proteins) in vascular endothelial cells by a process that requires the activation of STAT3
Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (show NOX1 Proteins)-mediated activation of STAT3.
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (show CCND2 Proteins) and PSEN1 (show PSEN1 Proteins) genes via a STAT3-dependent pathway
Studied effect of recombinant porcine leukemia inhibitory factor (show LIF Proteins) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (show FTH1 Proteins)-supplemented media.
Data suggest that IL-6 (interleukin 6 (show IL6 Proteins)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (show IL6 Proteins)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).
the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.
Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.
STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways
Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.
This is the first report of the genetic polymorphisms of the JAK1 (show JAK1 Proteins) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.
Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.
Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (show MMP2 Proteins) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.
PTPN9 (show PTPN9 Proteins) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (show GATA1 Proteins) and ZBP-89 (show ZNF148 Proteins).
Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.
Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.
This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.
The results of this study suggested that the stat3/socs3 (show SOCS3 Proteins) pathway is a key response in all tissue regeneration in zebrafish.
stat3, a known oncogene (show RAB1A Proteins) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.
Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (show PRCP Proteins) in neighboring cells during zebrafish gastrulation.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 3 (acute-phase response factor)
, signal transducer and activator of transcription 3
, signal transduction and activation of transcription 3
, Signal transducer and activator of transcription 3
, signal transducer and activator of transcription 3-like
, acute phase response factor
, acute-phase response factor
, DNA-binding protein APRF
, Protein Stat3
, signal transducer and activator of transcription 3.1
, stat 3