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Human STAT3 Protein expressed in Wheat germ - ABIN1321594
Qian, Chai, Liang, Wang, Zhou, Xu, Zhang, Zhang, Si, Huang, Huang, Hong, Wang: KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer. in Molecular cancer 2014
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Transplantation from GRIM19 (show NDUFA13 Proteins)-overexpressing cells downregulated the expression of nuclear factor of activated T cells (NFATc1 (show NFATC1 Proteins)) but promoted the expression of regulator of calcineurin (RCAN)3 (show RCAN3 Proteins) while downregulating NFAT (show NFATC1 Proteins)-dependent cytokine gene expression.
Data suggest MHV68 RTA (show RBM9 Proteins) specifically recognizes and recruits activated (phosphorylated at Tyr705) host Stat3 during lytic phase of infection; Stat3, once phosphorylated at Tyr705, avidly binds consensus target site in promoters of regulated genes. (MHV68 = murine gammaherpesvirus 68; RTA (show RBM9 Proteins) = replication and transcription activator coded for by ORF50; Stat3 = signal transducer and activator of transcription 3 protein)
Data suggest that CPA-7 (show CYP2A7 Proteins) therapeutic effects are due, at least in part, to functional depletion of signal transducer and activator of transcription 3 protein (STAT3) in prostate tumor tissue.
the existence of an unusual functional interplay between STATs and CREB (show CREB1 Proteins) at the onset of adipogenesis through shared CRTC cofactors, is reported.
By deacetylating and deacetyliminating Stat3 on multiple acetyl-lysine sites in nuclei, Loxl3 (show LOXL3 Proteins) regulates Stat3 dimerization and transcriptional activity. CD4 (show CD4 Proteins)+ T cell differentiation in inflammatory responses is regulated by the Loxl3 (show LOXL3 Proteins)-Stat3 signaling pathway
Schistosoma japonicum egg antigen p40 (show LANCL1 Proteins) through action on the STAT3/p53 (show TP53 Proteins)/p21 pathway triggered cellular senescence, while knockdown of p53 (show TP53 Proteins) or STAT3 partly restored cell senescence.
Collectively, these results uncover an independent functional contribution of the apo (show C9orf3 Proteins)-Rig-I (show DDX58 Proteins)/Stat3 interaction in the maintenance of Treg/Th17 cell balance.
The findings provide new insights into the role of STAT3 signaling in the maintenance of GC formation and GC B (show NPR2 Proteins) cell differentiation and identify STAT3 as a novel target for treatment ofSystemic lupus erythematosus (SLE).
Collectively, these data demonstrate that STAT3 is not required for overload-mediated hypertrophy in mouse skeletal muscle.
Reveal novel intracellular signaling mechanisms involving RhoA (show RHOA Proteins)/STAT3 underlying the contribution of reactive astrocyte dynamics to glial scar formation.
MiR (show MLXIP Proteins)-137 inhibited cell proliferation and migration of vascular smooth muscle cells via targeting IGFBP-5 (show IGFBP5 Proteins) and modulating the mTOR (show FRAP1 Proteins)/STAT3 signaling.
role of heat shock protein 90 (show HSP90 Proteins) in leptin (show LEP Proteins)-induced STAT3 activation and feeding regulation
Targeting Stat3/Nrf2 (show GABPA Proteins) pathway activated by PSC-secreted IL-6 (show IL6 Proteins) may provide a novel therapeutic option to improve the prognosis of PDAC.
These results suggest that the phosphorylation of STAT3 regulates MMP-9 (show MMP9 Proteins) production in ovarian cancer, which might be responsible for its invasiveness and metastasis.
We postulate that SIRT1 (show SIRT1 Proteins) and STAT3 are potential early diagnostic and prognostic markers of gastric cancer
High phosphorylated stat3 expression is associated with gallbladder cancer.
Mitochondria-targeted esculetin has anti-atherosclerotic effects by inhibiting PAI-1 (show SERPINE1 Proteins) levels by modulating miR (show MLXIP Proteins)-19b and -30c expression and affecting SIRT3 (show SIRT3 Proteins)- and STAT3-mediated signaling pathways.
Stromal ADSCs promote osteosarcoma progression by increasing STAT3 signalling-mediated MMP2 (show MMP2 Proteins)/9 expression.
we can exploit the STAT3 pathway for targeted drug therapy. Inhibition of pSTAT3 using HO-3867in ovarian clear cell carcinoma (OCCC) cell lines appears to be a promising therapy. This is of utmost importance given the poor response of OCCC to standard chemotherapy regimens.
STAT3 rs3816769 with the (C) allele and (CC) genotype was found to be protective for CD while the (T) allele and (TT) genotype increased the risk of late onset and stricturing the disease. rs957970 was found to be associated with only CD. rs8074524 was generally not associated with IBD. rs2293152 is one of the effective factors in the etiopathogenesis of both UC and CD. rs744166 showed a predisposition for only CD.
STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.
Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate
results show for the first time that interleukin-6 (show IL6 Proteins) (IL), in the presence of its soluble receptor (show IFNAR1 Proteins) (sIL-6R), induces activation of JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and STAT1 (show STAT1 Proteins)/STAT3 proteins in bovine articular chondrocytes
peroxynitrite causes increased expression of VEGF (show VEGFA Proteins) in vascular endothelial cells by a process that requires the activation of STAT3
Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (show NOX1 Proteins)-mediated activation of STAT3.
this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (show CCND2 Proteins) and PSEN1 (show PSEN1 Proteins) genes via a STAT3-dependent pathway
Studied effect of recombinant porcine leukemia inhibitory factor (show LIF Proteins) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (show FTH1 Proteins)-supplemented media.
Data suggest that IL-6 (interleukin 6 (show IL6 Proteins)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (show IL6 Proteins)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).
the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.
Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.
STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways
Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.
This is the first report of the genetic polymorphisms of the JAK1 (show JAK1 Proteins) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.
Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.
Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (show MMP2 Proteins) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.
Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a (show CDC25A Proteins) expression during oogenesis. Accordingly, restoring Cdc25a (show CDC25A Proteins) expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.
PTPN9 (show PTPN9 Proteins) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (show GATA1 Proteins) and ZBP-89 (show ZNF148 Proteins).
Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.
Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.
This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.
The results of this study suggested that the stat3/socs3 (show SOCS3 Proteins) pathway is a key response in all tissue regeneration in zebrafish.
stat3, a known oncogene (show RAB1A Proteins) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.
Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (show PRCP Proteins) in neighboring cells during zebrafish gastrulation.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 3 (acute-phase response factor)
, signal transducer and activator of transcription 3
, signal transduction and activation of transcription 3
, Signal transducer and activator of transcription 3
, signal transducer and activator of transcription 3-like
, acute phase response factor
, acute-phase response factor
, DNA-binding protein APRF
, Protein Stat3
, signal transducer and activator of transcription 3.1
, stat 3