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anti-Human STAT4 Antibodies:
anti-Mouse (Murine) STAT4 Antibodies:
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Mouse (Murine) Monoclonal STAT4 Primary Antibody for IF, WB - ABIN968254
Frank, Robertson, Bonni, Ritz, Greenberg: Interleukin 2 signaling involves the phosphorylation of Stat proteins. in Proceedings of the National Academy of Sciences of the United States of America 1995
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Human Monoclonal STAT4 Primary Antibody for ICS - ABIN1177205
Kisseleva, Bhattacharya, Braunstein, Schindler: Signaling through the JAK/STAT pathway, recent advances and future challenges. in Gene 2002
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Human Monoclonal STAT4 Primary Antibody for ICS - ABIN1177202
Visconti, Gadina, Chiariello, Chen, Stancato, Gutkind, OShea: Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity. in Blood 2000
Show all 2 Pubmed References
Human Polyclonal STAT4 Primary Antibody for ELISA, WB - ABIN4356389
Good, Thieu, Mathur, Yu, Stritesky, Yeh, OMalley, Perumal, Kaplan: Temporal induction pattern of STAT4 target genes defines potential for Th1 lineage-specific programming. in Journal of immunology (Baltimore, Md. : 1950) 2009
Human Polyclonal STAT4 Primary Antibody for IHC, WB - ABIN362570
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002
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IL13 (show IL13 Antibodies) AA of rs20541 and STAT4 TT of rs925847 are potential genomic biomarkers for predicting lower pulmonary function. The administration of high-dose ICSs to asthmatic patients with genetic variants of IL13 (show IL13 Antibodies) AA may inhibit the advancement of airway remodelling. The genetic variants of STAT4 TT did not respond to high-dose ICSs.
STAT4 mRNA expression was significantly correlated with IFNG (show IFNG Antibodies) mRNA expression.
findings demonstrate that variants in STAT4 play a critical role in HBV infection and clearance in the Chinese Han population.
STAT4 rs7574865G/T polymorphism is associated with rheumatoid arthritis and systemic lupus erythematosus in Mexican women
Results found that activated STAT4 was overexpressed in epithelial cells of ovarian cancer and provide evidence that it promotes ovarian cancer metastasis via tumor-derived Wnt7a (show WNT7A Antibodies)-induced activation of cancer-associated fibroblasts.
STAT4 rs7574865 gene polymorphism is associated with the susceptibility of primary biliary cirrhosis in the Han population of Jiangsu province.
The findings results confirm the important role of STAT4 gene in the predisposition to Systemic sclerosis and its phenotypes, such as the presence of Interstitial Lung disease , cardiac injury , and seropositivity for anti-topoisomerase I (show TOP1 Antibodies) antibodies in the Russian population.
results show specific and dominant contribution of STAT4 in the hematopoietic compartment to metabolic health and inflammation in diet-induced obesity.
reported that SNPs in STAT4, PTPN2 (show PTPN2 Antibodies), PSORS1C1 (show PSORS1C1 Antibodies), and TRAF3IP2 (show TRAF3IP2 Antibodies) are associated with response to TNF (show TNF Antibodies)-i treatment in RA patients; however, these findings should be validated in a larger population
This is the first demonstration of STAT4 acting as a transcriptional repressor in response to IFN-alpha (show IFNA Antibodies)/beta signaling and highlights the unique activity of this cytokine to acutely block the expression of an inflammatory cytokine in human T cells.
The results show that STAT4 plays a critical role in mediating both Th1 (show HAND1 Antibodies) and Th2 responses upon immunization with monophosphoryl lipid A.
this study shows that STAT4 regulates the CD8 (show CD8A Antibodies)(+) regulatory T cell/T follicular helper cell axis and promotes atherogenesis in insulin (show INS Antibodies)-resistant Ldlr (show LDLR Antibodies)(-/-) mice
virus-specific effector and memory CD4 (show CD4 Antibodies) T cells formed independently of Tbet and STAT4, although a slight reduction in the number of antigen-specific CD4 (show CD4 Antibodies) T cells was apparent in mice lacking both transcription factors.
STAT4 has a pro-atherogenic role that is at least partially independent of Th1 (show HAND1 Antibodies) cell-derived interferon-gamma (show IFNG Antibodies)
Modulation of IL-12 (show IL12A Antibodies)/STAT4 signaling may be a valuable therapeutic strategy to preserve islet/beta-cell viability in established diabetes
This study found that stathmin (show STMN1 Antibodies) plays an important role in adult hippocampal neurogenesis and spinogenesis. In addition, stathmin (show STMN1 Antibodies) mutation led to impaired NMDA receptor-dependent and neurogenesis-associated memory
STAT4 controls GM-CSF (show CSF2 Antibodies) production by both Th1 (show HAND1 Antibodies) and Th17 cells during experimental autoimmune encephalomyelitis.
Data (including data from studies in knockout mice) suggest Stat4 deletion reduces inflammation in peri (show POSTN Antibodies)-vascular and visceral adipose tissue and this appears to contribute via direct or indirect effects to reduced atheroma formation.
T-bet- and STAT4-dependent IL-33 (show IL33 Antibodies) receptor expression have roles in directly promoting antiviral Th1 (show HAND1 Antibodies) cell responses
Primary infections of mice with lymphocytic choriomeningitis virus (LCMV) demonstrated that T cell receptor stimulation induced responsiveness for IFN-gamma (show IFNG Antibodies) and CD25 (show IL2RA Antibodies) induction through STAT4-independent pathways.
These results suggest that the 2 single nucleotide polymorphisms of STAT4 could be used as genetic markers for milk performance traits in Chinese Holstein cows.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.
signal transducer and activator of transcription 4