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|Application / Reactivity||Rat (Rattus)||Mouse (Murine)|
|ELISA||10 Antibodies||15 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies||1 Antibodies|
|Immunocytochemistry (ICC)||1 Antibodies||1 Antibodies|
|Immunofluorescence (IF)||5 Antibodies||5 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||24 Antibodies||24 Antibodies|
|Immunohistochemistry (IHC)||31 Antibodies||37 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||8 Antibodies||12 Antibodies|
|Immunoprecipitation (IP)||8 Antibodies|
|Western Blotting (WB)||52 Antibodies|
|Flow Cytometry (FACS)||1 Antibodies|
|Gel Shift (GS)||2 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Antigen||Signal Transducer and Activator of Transcription 4 (STAT4) Antibodies|
|Epitope||AA 136-258 Alternatives|
|Reactivity||Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This STAT4 antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Western Blotting (WB)
|3 references available|
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Product Details anti-STAT4 AntibodyTarget Details STAT4 Application Details Handling References for anti-STAT4 Antibody (ABIN968254) Images
|Cross-Reactivity||Rat (Rattus), Mouse (Murine)|
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Immunogen||Human Stat4 aa. 136-258|
Target Details STAT4Product Details anti-STAT4 Antibody Application Details Handling References for anti-STAT4 Antibody (ABIN968254) Images back to top
|Alternative Name||Stat4 (STAT4 Antibody Abstract)|
The Stat proteins function as both cytoplasmic signal transducers and activators of transcription. Stat91/84 (the two proteins are the result of alternate splicing-Stat91 has an additional 38 C-terminal amino acids) and Stat113 were the first identified members of this protein family. With the discovery of additional members of the Stat family (Stat 3 & 4), the nomenclature has been revised to reflect the order of their discovery. Stat 91, 84, and 113 have become Stat1alpha, Stat1beta, and Stat2, respectively. Stat4 has been reported to be 52% identical to Stat1 and 47% identical to Stat3. Functionally, Stat4 is similar to the other Stat proteins in that it requires tyrosine phosphorylation in order to stimulate its IFN-gamma activated site (GAS) binding activity. Expression of Stat4 appears to be limited to thymus, spleen, and testis. Its expression in several myeloid cell lines is differentially regulated during cellular differentiation. Co-transfection studies using JAK1 or JAK2 expression constructs indicate that Stat4 is a substrate for these kinases.
Synonyms: Signal Transducers and Activators of Transcription-4
|Molecular Weight||89 kDa|
|Research Area||Signaling, Receptors, Inflammation|
Application DetailsProduct Details anti-STAT4 Antibody Target Details STAT4 Handling References for anti-STAT4 Antibody (ABIN968254) Images back to top
Related Products: ABIN967389
|Restrictions||For Research Use only|
HandlingProduct Details anti-STAT4 Antibody Target Details STAT4 Application Details References for anti-STAT4 Antibody (ABIN968254) Images back to top
|Buffer||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at -20° C.|
References for anti-STAT4 Antibody (ABIN968254)Product Details anti-STAT4 Antibody Target Details STAT4 Application Details Handling Images back to top
|Product cited in:||
Frank, Robertson, Bonni, Ritz, Greenberg: "Interleukin 2 signaling involves the phosphorylation of Stat proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 17, pp. 7779-83, 1995
Yamamoto, Quelle, Thierfelder, Kreider, Gilbert, Jenkins, Copeland, Silvennoinen, Ihle: "Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation." in: Molecular and cellular biology, Vol. 14, Issue 7, pp. 4342-9, 1994
Zhong, Wen, Darnell: "Stat3 and Stat4: members of the family of signal transducers and activators of transcription." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 11, pp. 4806-10, 1994
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