Browse our STAT5A Proteins (STAT5A)

Full name:
Signal Transducer and Activator of Transcription 5A Proteins (STAT5A)
On www.antibodies-online.com are 11 Signal Transducer and Activator of Transcription 5A (STAT5A) Proteins from 7 different suppliers available. Additionally we are shipping STAT5A Antibodies (470) and STAT5A Kits (40) and many more products for this protein. A total of 564 STAT5A products are currently listed.
Synonyms:
AA959963, MGF, Stat5, STAT5A, STAT5A/MGF, STATA5
list all proteins Gene Name GeneID UniProt
STAT5A 6776 P42229
STAT5A 20850 P42230
STAT5A 24918 Q62771

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STAT5A Proteins (STAT5A) by Origin

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More Proteins for STAT5A Interaction Partners

Human Signal Transducer and Activator of Transcription 5A (STAT5A) interaction partners

  1. All merkel cell carcinoma (MCC (show MCC Proteins)) cases with a good outcome expressed pSTAT5B, whereas all MCC (show MCC Proteins) cases with a poor outcome did not express pSTAT5B; hence, pSTAT5B expression may be an indicator of positive prognosis in patients with MCC (show MCC Proteins).

  2. High STAT5A expression is associated with B-lymphoblastic lymphoma with inflammation.

  3. Results provide evidence that HDAC6 (show HDAC6 Proteins) could regulate HMGN2 (show HMGN2 Proteins) acetylation levels and binding to Stat5a-responsive promoters, and therefore, Stat5a transcriptional activity in breast cancer cells.

  4. Sustained STAT5 transcription factor (STAT5) phosphorylation is necessary to induce long-term interleukin 2 receptor subunit alpha (CD25 (show IL2RA Proteins)) expression in T lymphocytes.

  5. BCR/ABL (show ABL1 Proteins) positively regulates the expression of EZH2 (show EZH2 Proteins) via STAT5 signaling.

  6. these results demonstrate that the oncogenic signal transducer and activator of transcription 5/Akt (show AKT1 Proteins) pathway is a cellular target for indole-3-carbinol in chronic myeloid leukemia (show BCL11A Proteins) cells. Thus, this clinically tested natural compound can be a potential candidate in the treatment of chronic myeloid leukemia (show BCL11A Proteins) following confirmation with clinical studies

  7. elucidate a novel mechanism whereby the linker histone H1 (show H1F0 Proteins) prevents STAT5 binding at promoter DNA, and the PRL (show PRL Proteins)-induced dissociation of H1 mediated by HMGN2 (show HMGN2 Proteins) is necessary to allow full STAT5 recruitment and promote the biological effects of PRL (show PRL Proteins) signaling

  8. The balance between IL-2 (show IL2 Proteins)-induced STAT5 activation, regulated by TCR signaling, and STAT3 (show STAT3 Proteins) activation, regulated by pro-Th17 cytokines, is likely to be critical in determining the level of Th17 polarization.

  9. These results reveal a novel role of IL-7 (show IL7 Proteins) and IL-15 (show IL15 Proteins) in maintaining human T cell function, provide an explanation for T cell dysfunction in humanized mice, and have significant implications for in vitro studies with human T cells.

  10. STAT5 activation in the dermal papilla is important for hair follicle growth inductaion.

Mouse (Murine) Signal Transducer and Activator of Transcription 5A (STAT5A) interaction partners

  1. deregulation of local signal transducer and activator of transcription 5 signaling augments high fat diet-induced lipid accumulation in both muscle and liver.

  2. Data show that CUZD1 (show CUZD1 Proteins) interacts with a complex containing JAK1 (show JAK1 Proteins)/JAK2 (show JAK2 Proteins) and STAT5, downstream transducers of prolactin (show PRL Proteins) signaling in the mammary gland.

  3. The study describes an interaction network of STAT5a/LSD1 (show KDM1A Proteins)/HDAC3 (show HDAC3 Proteins) and a dual function of LSD1 (show KDM1A Proteins)/HDAC3 (show HDAC3 Proteins) on STAT5a-dependent transcription, defined by protein-protein interactions, genomic binding localization/affinity and motifs.

  4. this study shows that lipoxin A4 protects against LPS (show TLR4 Proteins)-induced sepsis by promoting the generation and migration of splenic innate response activator B cells, and the underlying molecular mechanism may be related to STAT5 activation

  5. Study showed that suppression of STAT3 (show STAT3 Proteins), STAT5, and STAT6 (show STAT6 Proteins) and overexpression of the proapoptotic factor STAT1 (show STAT1 Proteins), which provides p53 (show TP53 Proteins)-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 (show ERBB2 Proteins) tyrosine kinase receptor (show KDR Proteins) overexpression promotes neuronal survival through activation of STAT (show STAT1 Proteins)-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1 (show STAT1 Proteins)

  6. Mechanistically, RL negatively regulates Stat5 phosphorylation and Elf5 (show ELF5 Proteins) expression at the onset of lactogenesis. Continuous RL exposure leads to the expansion of basal and bipotent cells in WT and MMTV-RANK acini. Overall, we demonstrate that enhanced Rank signaling impairs secretory differentiation during pregnancy by inhibition of the prolactin (show PRL Proteins)/p-Stat5 pathway.

  7. Bcl6 (show BCL6 Proteins) promoted T follicular helper cell differentiation through antagonizing IL-7R / STAT5a axis.

  8. constitutive STAT5 binding to c-Myc (show MYC Proteins) super-enhancer might contribute to BRD2 (show BRD2 Proteins) maintenance and thus allow sustained expression of c-Myc (show MYC Proteins) in Ba/F3 cells transformed by STAT5-1*6.

  9. Foxp3 (show FOXP3 Proteins) has a rapid turn over in Treg partly controlled at the transcriptional level by the JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) pathway

  10. transduction of developing Th9 cells with a constitutively active STAT5 eliminates the ability of IL-6 (show IL6 Proteins) to reduce IL-9 (show IL9 Proteins) production.

Pig (Porcine) Signal Transducer and Activator of Transcription 5A (STAT5A) interaction partners

Cow (Bovine) Signal Transducer and Activator of Transcription 5A (STAT5A) interaction partners

  1. There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.

  2. Milk production traits were analyzed for each animal in the first, second, third, and fourth lactation. No genetic variability was found at STAT5A/AvaI locus. At STAT5A/MslI locus, the frequencies of T and C alleles were 0.875 and 0.125, respectively. Significant differences between genotypes were found

  3. Results indicate that SNPs in STAT5A and JAK2 (show JAK2 Proteins) genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.

  4. The embryonic STAT5A gene is primarily activated by maternal gene products and the most abundant STAT5A expression occurred at the 2-cell stage blastocysts.

  5. INVESTIGATION OF STAT5A, FSHR (show FSHR Proteins) AND LHR (show LHCGR Proteins) GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS

  6. The Stat5a gene is associated with an increase in lactation of mammary gland epithelial cells.

  7. STAT5A/AvaI polymorphism seems to be a promising indirect marker to improve milk production traits in cattle.

  8. Associations between reproduction and milk traits, and polymorphisms at the STAT5A and FGF2 (show FGF2 Proteins) gene loci, were found with STAT5A polymorphism for age at first calving (suggestive effect; P =0.077) and lactation milk yield (significant effect; P<0.05).

  9. Base sequence variation in STAT5A-noncoding region was studied.

  10. The association of fertilization rate with STAT5A polymorphisms was evaluated in ocytes. Associations were found for 6 and 2 SNP. 5 SNP showed associations with both embryonic survival and fertilization rate compared with 1 SNP.

STAT5A Protein Profile

Protein Summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Alternative names and synonyms associated with STAT5A

  • signal transducer and activator of transcription 5A (STAT5A)
  • signal transducer and activator of transcription 5A (Stat5a)
  • signal transducer and activator of transcription 5A-like (LOC100348518)
  • signal transducer and activator of transcription 5B (STAT5B)
  • AA959963 protein
  • MGF protein
  • Stat5 protein
  • STAT5A protein
  • STAT5A/MGF protein
  • STATA5 protein

Protein level used designations for STAT5A

signal transducer and activator of transcription 5A , signal transducer and activator of transcription 5A-like , mammary gland factor STAT5A , mammary gland factor , signal transducer and activator of transcription 5 , STAT5A, Mammary Gland Factor , transcription factor STAT5B

GENE ID SPECIES
100052904 Equus caballus
454681 Pan troglodytes
574129 Macaca mulatta
100461695 Pongo abelii
6776 Homo sapiens
20850 Mus musculus
24918 Rattus norvegicus
490968 Canis lupus familiaris
397550 Sus scrofa
282375 Bos taurus
100716811 Cavia porcellus
443419 Ovis aries
100348518 Oryctolagus cuniculus
6777 Homo sapiens
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