anti-Cow (Bovine) STAT6 antibody for Intracellular Staining

Recommended STAT6 Antibody (supplied by: Log in to see )

Antigen
Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) Antibodies
  • D12S1644
  • IL-4-STAT
  • STAT6B
  • STAT6C
  • signal transducer and activator of transcription 6, interleukin-4 induced
  • signal transducer and activator of transcription 6
  • signal transducer and activator of transcription 6-like
  • STAT6
  • Stat6
  • LOC100859543
Epitope
C-Term
91
41
18
17
15
15
12
11
6
6
5
5
5
5
5
4
4
4
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
427
187
131
24
20
16
15
14
9
6
3
2
1
1
1
Host
Mouse
285
168
6
1
1
Clonality
Monoclonal
Conjugate
This STAT6 antibody is conjugated to PE
15
15
15
14
12
10
7
7
6
5
5
5
5
5
5
5
5
5
5
4
4
3
3
3
3
3
3
3
2
Application
Intracellular Staining (ICS)
338
148
135
67
52
44
40
39
34
10
5
4
3
3
2
1
1
1
1
1
1
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Catalog No. ABIN1176939
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1176940 ICS Alexa Fluor 647 Mouse IgG1 C-Term Log in to see 23-Stat6 1

General

Antigen Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) Antibodies
Epitope C-Term
(91), (41), (18), (17), (15), (15), (12), (11), (6), (6), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
(427), (187), (131), (24), (20), (16), (15), (14), (9), (6), (3), (2), (1), (1), (1)
Host Mouse
(285), (168), (6), (1), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This STAT6 antibody is conjugated to PE
(15), (15), (15), (14), (12), (10), (7), (7), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (3), (3), (3), (3), (3), (3), (3), (2)
Application Intracellular Staining (ICS)
(338), (148), (135), (67), (52), (44), (40), (39), (34), (10), (5), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Pubmed 1 reference available
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Product Details anti-STAT6 Antibody

Target Details STAT6 Application Details Handling ProductDetails: References for anti-STAT6 antibody (ABIN1176939) Images
Brand BD Phosflow™
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Human Stat6 C-terminal Recombinant Protein
Clone 23-Stat6
Isotype IgG1

Target Details STAT6

Product Details anti-STAT6 Antibody Application Details Handling ProductDetails: References for anti-STAT6 antibody (ABIN1176939) Images back to top
Antigen
Alternative Name Stat6 (STAT6 Antibody Abstract)
Background STATs (signal transducers and activators of transcription) are critical mediators of the biologic activity of cytokines including Interleukins (IL) 2-5, IL-7, IL-15, GM-CSF, erythropoietin and growth hormone. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of STATs by tyrosine phosphorylation. Active STATs then move to the nucleus to promote transcription of cytokine-inducible genes. Seven STAT proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat6 plays an important role in signaling pathways that lead to the differentiation of T helper type 2 (Th2) cells from uncommitted CD4 T cell precursors. Moreover, IL-4, secreted by activated T lymphocytes, basophils, and mast cells, induces specific gene expression via the induction of tyrosine phosphorylation of Stat6 at tyrosine 641 (Y641). The SH3:SH2 domain of Stat6 associates with tyrosine-phosphorylated IL-4 receptor and the proximal Jak kinase phosphorylates Stat6 at Y641 on the C-terminal side of the SH2 domain. Stat6 is then released from the receptor, dimerizes, and is thought to contact the basal transcription machinery by binding to p300/CBP. While Stat6 is widely expressed in human tissues, it exhibits elevated expression in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta. The 23/Stat6 monoclonal antibody recognizes Stat6, regardless of phosphorylation status.
Research Area Inflammation
Pathways JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response

Application Details

Product Details anti-STAT6 Antibody Target Details STAT6 Handling ProductDetails: References for anti-STAT6 antibody (ABIN1176939) Images back to top
Sample Volume 20 μL
Restrictions For Research Use only

Handling

Product Details anti-STAT6 Antibody Target Details STAT6 Application Details ProductDetails: References for anti-STAT6 antibody (ABIN1176939) Images back to top
Format Liquid
Buffer Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed. Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

ProductDetails: References for anti-STAT6 antibody (ABIN1176939)

Product Details anti-STAT6 Antibody Target Details STAT6 Application Details Handling Images back to top
Product cited in:

Heim: "The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus." in: European journal of clinical investigation, Vol. 26, Issue 1, pp. 1-12, 1996

Images

Product Details anti-STAT6 Antibody Target Details STAT6 Application Details Handling ProductDetails: References for anti-STAT6 antibody (ABIN1176939) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (C-Term) antibody (PE) (ABIN1176939) anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (C-Term) antibody (PE)