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anti-Human STAT6 antibody for Immunofluorescence

Recommended STAT6 Antibody (supplied by: Log in to see )

Antigen
Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) Antibodies
  • D12S1644
  • IL-4-STAT
  • STAT6B
  • STAT6C
Epitope
pTyr641
80
38
23
13
13
11
10
10
7
6
5
5
5
5
4
4
4
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
387
140
102
12
8
7
6
4
2
1
Host
Mouse
255
159
3
1
Clonality
Monoclonal
Conjugate
This STAT6 antibody is un-conjugated
14
12
12
12
10
9
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
2
1
1
1
Application
Immunofluorescence (IF), Intracellular Staining (ICS), Western Blotting (WB)
307
144
112
52
45
37
33
25
17
14
6
4
2
1
1
1
1
1
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Catalog No. ABIN968593
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.32104653 ABIN968594 IF WB Mouse IgG2a pTyr641 Log in to see 18-P 3
0.32104653 ABIN1109154 EIA IF WB Mouse IgG1 Log in to see 7D3 3
0.32104653 ABIN2506025 IF ELISA WB Mouse IgG1 Log in to see 7D3
0.32104653 ABIN520549 IF WB Mouse AA 1-847, full length Log in to see Polyclonal
0.32104653 ABIN520553 IF ELISA WB Mouse IgG2a kappa AA 694-801, partial Log in to see 4G7
0.32104653 ABIN563038 IF IHC (p) ELISA WB Mouse IgG2b kappa AA 694-801, partial Log in to see 6C10
0.32104653 ABIN520550 IF WB Mouse AA 1-847, full length Log in to see Polyclonal
0.32104653 ABIN3199276 IF IHC (p) WB Mouse IgG2b AA 695-804 Log in to see 6C10
0.32104653 ABIN2649410 IF Mouse Log in to see
0.0010843398 ABIN1533014 IF IHC ELISA WB Rabbit IgG Log in to see Polyclonal 2
0.0010843398 ABIN968456 IF WB Mouse IgG1 C-Term Log in to see 23-Stat6 9
0.0010843398 ABIN968455 IF WB Mouse IgG1 C-Term Log in to see 23-Stat6 9
0.0010843398 ABIN1501202 ICC IF ELISA WB Mouse IgG1 Log in to see 7D3
0.0010843398 ABIN968672 IF WB Rabbit Ig pTyr641 Log in to see Polyclonal 3
0.0010843398 ABIN968671 IF WB Rabbit Ig pTyr641 Log in to see Polyclonal 3
0.0010843398 ABIN967099 IF ELISA WB Mouse IgG1 Log in to see 7D3 3
0.0010843398 ABIN790596 IF IHC (p) ELISA WB Mouse IgG2b, kappa Log in to see 6C10
0.0010843398 ABIN2506030 IF IP IHC ELISA WB Rabbit IgG Thr645 Log in to see Polyclonal
0.0010843398 ABIN393847 IF WB Mouse IgG2b kappa AA 695-804 Log in to see 6C10
0.0010843398 ABIN218722 ICC FACS IF IP ELISA WB Rabbit IgG pTyr641 Log in to see Polyclonal

Top referenced anti-STAT6 antibody for Immunofluorescence

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Application / Reactivity Human
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Chromatin Immunoprecipitation (ChIP) 1 Antibodies
ELISA 138 Antibodies
ELISA (Capture) 1 Antibodies
Enzyme Immunoassay (EIA) 4 Antibodies
Flow Cytometry (FACS) 25 Antibodies
Immunoassay (IA) 1 Antibodies
Immunochromatography (IC) 1 Antibodies
Immunocytochemistry (ICC) 15 Antibodies
Immunofluorescence (IF) 38 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 22 Antibodies
Immunohistochemistry (IHC) 114 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 4 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 42 Antibodies
Immunoprecipitation (IP) 53 Antibodies
Intracellular Staining (ICS) 12 Antibodies
Western Blotting (WB) 296 Antibodies

General

Antigen Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) Antibodies
Epitope pTyr641
(80), (38), (23), (13), (13), (11), (10), (10), (7), (6), (5), (5), (5), (5), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(387), (140), (102), (12), (8), (7), (6), (4), (2), (1)
Host Mouse
(255), (159), (3), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This STAT6 antibody is un-conjugated
(14), (12), (12), (12), (10), (9), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (2), (1), (1), (1)
Application Immunofluorescence (IF), Intracellular Staining (ICS), Western Blotting (WB)
(307), (144), (112), (52), (45), (37), (33), (25), (17), (14), (6), (4), (2), (1), (1), (1), (1), (1)
Pubmed 3 references available
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Product Details anti-STAT6 Antibody

Target Details STAT6 Application Details Handling References for anti-STAT6 Antibody (ABIN968593) Images
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Phosphorylated Human Stat6 (pY641)
Clone 18-P
Isotype IgG2a

Target Details STAT6

Product Details anti-STAT6 Antibody Application Details Handling References for anti-STAT6 Antibody (ABIN968593) Images back to top
Antigen
Alternative Name Stat6 (STAT6 Antibody Abstract)
Background Interleukin-4 (IL-4), a major immunoregulatory cytokine, is secreted by activated T lymphocytes, basophils, and mast cells and plays an important role in modulating T helper cell lineage development. It induces specific gene expression via the tyrosine phosphorylation of Stat6 at tyrosine 641 (Y641). Stat6, a member of the signal transducers and activators of transcription protein family, mediates signals for IL-4 and, possibly, IL-13. While Stat6 is widely expressed in human tissues, it exhibits elevated expression in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta. Following cytokine receptor ligation, Jak kinases are activated and phosphorylate the cytoplasmic tails of the oligomerized receptors. The SH3:SH2 domain of Stat6 associates with tyrosine-phosphorylated IL-4 receptor and the proximal Jak kinase phosphorylates Stat6 at Y641 on the C-terminal side of the SH2 domain. Stat6 is then released from the receptor, dimerizes, and is thought to contact the basal transcription machinery by binding to p300/CBP. Thus, Stat6 mediates the IL-4 signal and is essential for the proper development of adaptive immunity.
Molecular Weight 100 kDa
Research Area Signaling, Receptors, Inflammation
Pathways JAK-STAT Signaling

Application Details

Product Details anti-STAT6 Antibody Target Details STAT6 Handling References for anti-STAT6 Antibody (ABIN968593) Images back to top
Restrictions For Research Use only

Handling

Product Details anti-STAT6 Antibody Target Details STAT6 Application Details References for anti-STAT6 Antibody (ABIN968593) Images back to top
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.

References for anti-STAT6 Antibody (ABIN968593)

Product Details anti-STAT6 Antibody Target Details STAT6 Application Details Handling Images back to top
Product cited in:

Mikita, Campbell, Wu, Williamson, Schindler: "Requirements for interleukin-4-induced gene expression and functional characterization of Stat6." in: Molecular and cellular biology, Vol. 16, Issue 10, pp. 5811-20, 1996

Hou, Schindler, Henzel, Ho, Brasseur, McKnight: "An interleukin-4-induced transcription factor: IL-4 Stat." in: Science (New York, N.Y.), Vol. 265, Issue 5179, pp. 1701-6, 1994

Background publications

Quelle, Shimoda, Thierfelder, Fischer, Kim, Ruben, Cleveland, Pierce, Keegan, Nelms: "Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis." in: Molecular and cellular biology, Vol. 15, Issue 6, pp. 3336-43, 1995

Images

Product Details anti-STAT6 Antibody Target Details STAT6 Application Details Handling References for anti-STAT6 Antibody (ABIN968593) back to top
Supplier Images
Immunofluorescence (IF) image for anti-STAT6 antibody (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced) (pTyr641) (ABIN968593) Immunofluorescent labelling of phosphorylated Stat6 in endothelial cells exposed to 1...
 image for anti-STAT6 antibody (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced) (pTyr641) (ABIN968593) Human Endothelial cells were either untreated (left column) or treated with (right co...