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Human STAT6 ELISA Kit for Cell ELISA - ABIN1981845
Quelle, Shimoda, Thierfelder, Fischer, Kim, Ruben, Cleveland, Pierce, Keegan, Nelms: Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. in Molecular and cellular biology 1995
Show all 8 Pubmed References
Gefitinib effectively inhibits tumor-associated macrophage M2-like polarization both in vitro and in vivo by targeting the STAT6 signaling pathway.
M1 macrophages with inhibited STAT3 (show STAT3 ELISA Kits), STAT6 and/or SMAD3 (show SMAD3 ELISA Kits) effectively restrict tumor growth. The findings justify the development of new anti-tumor cell therapy technology.
cytokine-activated STAT3 and STAT6 cooperate in macrophages to promote a secretory phenotype that enhances tumor progression in a cathepsin-dependent manner.
these results demonstrate that a STAT6-dependent macrophage phenotype promotes mucosal repair in murine inflammatory bowel disease through activation of the Wnt (show WNT2 ELISA Kits) signaling pathway
These data indicate a role for STAT3 (show STAT3 ELISA Kits) in maintaining a steady state in the beta-cell, by modulating its cell cycle and protection from DNA damage.
STAT6 phosphorylation (p-STAT6) was significantly increased in TECs from both Grave's disease patients and experimental autoimmune Graves' disease mice.
this study shows that sodium benzoate induces the expression of TGF-beta (show TGFB1 ELISA Kits) in splenocytes and alleviates experimental allergic encephalomyelitis via the STAT6-TGF-beta (show TGFB1 ELISA Kits)-Treg pathway
this study shows that wild-type mice develop an eosinophilic Th2 airway disease in response to Alternaria alternata exposure, whereas STAT6-deficient mice exhibit a primarily neutrophilic response
this study shows that IL-17A (show IL17A ELISA Kits) contributes to asthma pathophysiology by increasing the capacity of IL-13 (show IL13 ELISA Kits) to activate intracellular signaling pathways, such as STAT6 activation
RCM-1 (show TNNI3 ELISA Kits) reduced IL-13 (show IL13 ELISA Kits) and STAT6 (signal transducer and activator of transcription 6) signaling and prevented the expression of the STAT6 target genes Spdef and Foxa3 (show FOXA3 ELISA Kits), which are key transcriptional regulators of goblet cell differentiation.
Data suggest that STAT6 and RANKL (show TNFSF11 ELISA Kits) are involved in regulation of apoptosis, gene expression, and cell proliferation in hepatocellular carcinoma cell lines; depletion of STAT6 using RNA interference increases apoptosis; this mechanism involves down-regulation of expression of RANKL (show TNFSF11 ELISA Kits). (STAT6 = signal transducer and activator of transcription 6; RANKL (show TNFSF11 ELISA Kits) = receptor activator of nuclear factor kappa B ligand (show TNFSF11 ELISA Kits))
The results showed that SARS (show SARS ELISA Kits) coronavirus papain-like protease (PLPro) stimulated TGF-beta1 (show TGFB1 ELISA Kits)-dependent expression of Type I collagen via activating STAT6 pathway.
High STAT6 expression is associated with melanoma.
Report a variant of t(14;18) negative nodal diffuse follicular lymphoma with CD23 (show FCER2 ELISA Kits) expression, 1p36/TNFRSF14 (show TNFRSF14 ELISA Kits) abnormalities, and STAT6 mutations.
Our data indicate that hypoxic inhibition of JMJD3 (show Kdm6b ELISA Kits) activity reduces demethylation of H3K27me3, nucleosome removal, and hence induction of the STAT6 target gene CCL18 (show CCL18 ELISA Kits), while induction of other STAT6-inducible genes such as SPINT2 (show SPINT2 ELISA Kits) remained unaffected by JMJD3 (show Kdm6b ELISA Kits).
The results suggest that nuclear localization and cleavage of STAT6 is important for modulating the viral latency and pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV).
the phosphorylation of signal transducer and activator of transcription 1 (STAT1 (show STAT1 ELISA Kits)-py) was impaired in asthmatics, whereas the phosphorylation of signal transducer and activator of transcription 6 (STAT6-py) was slightly enhanced.
PVT1-derived miR (show MLXIP ELISA Kits)-1207-5p promotes the proliferation of breast cancer cells by targeting STAT6.
STAT6 single-nucleotide polymorphism is associated with migraine.
this study shows that weaning caused severe inflammation associated with the suppression of STAT6 in the jejunum of piglets
Data show that IL-4 (show IL4 ELISA Kits) induces upregulation of the junction protein claudin-5 (show CLDN5 ELISA Kits) in endothelial cells (ECs) through activation of Jak (show JAK3 ELISA Kits)/STAT6 and phosphorylation and translocation of FoxO1 (show FOXO1 ELISA Kits) from the nucleus to the cytoplasm.
Results provide evidence that polymorphisms in STAT6 are associated with carcass and growth efficiency traits
IL-4 (show IL4 ELISA Kits) and STAT6 are related to the pathogenesis of allergic rhinitis and may be the main factors for eosinophil infiltration in allergic rhinitis.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
signal transducer and transcription activator 6
, STAT, interleukin4-induced
, signal transducer and activator of transcription 6
, transcription factor IL-4 STAT