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|Application / Reactivity||Cynomolgus|
|Antigen||Thrombopoietin (THPO) Antibodies|
|Epitope||AA 1-353 Alternatives|
|Conjugate||This Thrombopoietin antibody is un-conjugated Alternatives|
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Product Details anti-Thrombopoietin AntibodyTarget Details Thrombopoietin Application Details Handling Images
|Specificity||Cynomolgus Thrombopoietin / THPO|
|Characteristics||Produced in rabbits immunized with purified, recombinant Cynomolgus Thrombopoietin / THPO (rCynomolgus Thrombopoietin / THPO, ABIN2009677 Met 1-Gly 353,. Thrombopoietin / THPO specific IgG was purified by Cynomolgus Thrombopoietin / THPO affinity chromatography.|
|Purification||purified by affinity chromatography|
|Sterility||0.2 μm filtered|
|Immunogen||Recombinant Cynomolgus Thrombopoietin / THPO protein (ABIN2009677)|
Target Details ThrombopoietinProduct Details anti-Thrombopoietin Antibody Application Details Handling Images back to top
|Alternative Name||THPO (THPO Antibody Abstract)|
|Background||Thrombopoietin (TPO or THPO), also known as myeloproliferative leukemia virus ligand (c-Mpl), is a hematopoietic growth factor belonging to the EPO/TPO family. The thrombopoietin protein is produced mainly by the liver and the kidney that regulates the production of platelets by the bone marrow. Thrombopoietin protein stimulates both proliferation of progenitor megakaryocytes and their maturation to platelet-producing megakaryocytes, and also accelerates the recovery of platelets. Thrombopoietin protein is involved in cardiovascular disease as it regulates megakaryocyte development and enhances platelet adhesion/aggregation. It has been identified that surface c-MPL, the receptor for thrombopoietin protein, binds to the ligand and mediates the action.|
|Pathways||JAK-STAT Signaling, Hormone Activity|
Application DetailsProduct Details anti-Thrombopoietin Antibody Target Details Thrombopoietin Handling Images back to top
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Cynomolgus THPO. The detection limit for Cynomolgus THPO is approximately 0.00245 ng/well.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Thrombopoietin Antibody Target Details Thrombopoietin Application Details Images back to top
|Buffer||0.2 μm filtered solution in PBS with 5 % trehalose|
|Handling Advice||Avoid repeated freeze-thaw cycles.|
|Storage||4 °C,-20 °C,-80 °C|
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
|Expiry Date||12 months|