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Cdc20 (show CDC20 Proteins) requires APC3 and APC8 (show CDC23 Proteins) to bind and activate the APC (show APC Proteins)/C when the spindle assembly checkpoint is satisfied, but only APC8 (show CDC23 Proteins) when active, and APC10 is crucial for the destruction of cyclin B1 (show CCNB1 Proteins) and securin (show PTTG1 Proteins), but not cyclin A (show CCNA2 Proteins)
Substrates are recruited to the Anaphase-promoting complex by binding to a bipartite substrate receptor composed of Cdh1 (show CDH1 Proteins) and Doc1 (show CDK2AP1 Proteins).
ANAPC10 was mainly expressed in the cytoplasm of spermatogonia and leptotene and pachytene spermatocytes.
Partial cDNA, intron 1 and 5'-flanking sequences of porcine APC10, were cloned and sequenced.
ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1\; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1\; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1\; MIM 116940) (summary by Wendt et al., 2001
, anaphase promoting complex subunit 10
, potential anaphase-promoting complex processivity factor Apc10
, hypothetical protein
, anaphase-promoting complex subunit 10
, cyclosome subunit 10