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Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 (show ANAPC5 ELISA Kits) and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1 (show CDH1 ELISA Kits).
Studies indicate that APC (show APC ELISA Kits)/C(Cdh1 (show CDH1 ELISA Kits)) is required to maintain genomic stability.
Arabidopsis APC4 plays critical roles in female gametogenesis and embryogenesis, possibly as a connector in APC (show APC ELISA Kits)/C, and that regulation of auxin distribution may be involved in these processes.
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known.
anaphase-promoting complex subunit 4
, anaphase promoting complex subunit 4
, Cyclosome subunit 4
, cyclosome subunit 4