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anti-Human Dynactin 1 Antibodies:
anti-Mouse (Murine) Dynactin 1 Antibodies:
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Chicken Monoclonal Dynactin 1 Primary Antibody for IF, IHC (zinc) - ABIN967995
Askham, Vaughan, Goodson, Morrison: Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome. in Molecular biology of the cell 2002
Show all 5 Pubmed References
Chicken Monoclonal Dynactin 1 Primary Antibody for IF, IHC (zinc) - ABIN967996
Aumais, Tunstead, McNeil, Schaar, McConnell, Lin, Clark, Yu-Lee: NudC associates with Lis1 and the dynein motor at the leading pole of neurons. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2001
Show all 5 Pubmed References
Human Polyclonal Dynactin 1 Primary Antibody for IHC (p), IHC - ABIN249667
Bupha-Intr, Haizlip, Janssen: Temporal changes in expression of connexin 43 after load-induced hypertrophy in vitro. in American journal of physiology. Heart and circulatory physiology 2009
Show all 2 Pubmed References
Dog (Canine) Monoclonal Dynactin 1 Primary Antibody for BI, IF - ABIN968918
Holzbaur, Hammarback, Paschal, Kravit, Pfister, Vallee: Homology of a 150K cytoplasmic dynein-associated polypeptide with the Drosophila gene Glued. in Nature 1991
Show all 2 Pubmed References
Dog (Canine) Monoclonal Dynactin 1 Primary Antibody for BI, IF - ABIN968919
Waterman-Storer, Karki, Holzbaur: The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1). in Proceedings of the National Academy of Sciences of the United States of America 1995
Show all 2 Pubmed References
Arfaptin (show ARFIP1 Antibodies) physically associates with Glued and other dynactin complex components in the nervous system of both flies and mice and colocalizes with Glued at the Golgi in motor neurons.
It uncovered an important requirement for Lis1 (show PAFAH1B1 Antibodies) in promoting the recruitment of dynein and its accessory complex dynactin to RNA localization complexes.
multiple independent disruptions of Dynactin function cause a relocation of the photoreceptor nucleus toward the brain
dynein-dynactin, abnormal spindle protein (Asp (show ASIP Antibodies)), and KLP10A (show KIF24 Antibodies) have roles in Drosophila spindle pole organization
We conclude that Lis1 (show PAFAH1B1 Antibodies)/dynactin act together to regulate multiple, independent functions in mitotic cells, including spindle formation and cell cycle checkpoint release.
Microtubule binding depends on the N-terminal domain of p150[glued].
Mutants in the Lis1 (show PAFAH1B1 Antibodies)/dynactin complex strongly decrease maximum and average spindle velocity, consistent with this motor complex mediating spindle/cortex forces.
Dynein-dynactin plays a role in excluding dendritic Dscam (show DSCAM Antibodies) from axons by retrograde transport.
show that this cell polarity regulator interacts with Glued during central synapse formation.
Results suggested that variants in DCTN1 are not common risk factors for Chinese sporadic amyotrophic lateral sclerosis and that the frequency of variants of unknown significance in the cohort study was 0.39%.
This work reveals the structural details of Hook3 (show HOOK3 Antibodies)'s interaction with dynein and offers insight into how cargo adaptors form processive dynein-dynactin motor complexes.
No DCTN1 variants of disease significance were identified in this study suggesting the dynactin genes are unlikely to be a common cause of inherited peripheral neuropathies.
Mutations in the Dynactin 1 (DCTN1) gene have been demonstrated to result in various neurodegenerative diseases, including distal hereditary motor neuropathy type 7B. In the present study, a p.G59S mutation was identified as the underlying cause of Distal hereditary motor neuropathy type 7B in two families, and their detailed clinical features were characterized.
Study found that in peripheral blood mononuclear cells the median expression of KIFC3 (show KIFC3 Antibodies), KIF1B (show KIF1B Antibodies), and KIF5C (show KIF5C Antibodies) was much lower than the expression of dynactin subunits DCTN1 and DCTN3 (show Dctn3 Antibodies), in both sporadic amyotrophic lateral sclerosis and healthy cases
Data suggest that cargo concentration at ERES is regulated by p150(glued) to coordinate protein sorting and transport carrier formation with the subsequent long-range transport towards the Golgi complex along microtubules.
Study shows p150glued located at the centrosome in a cell cycle-dependent manner where it is abundant during G1/S phase, located in the minus-end of microtubules during G2/M phase and at the minus-end of microtubules in the mitotic phase.
We find that LRRK1-mediated phosphorylation of CLIP-170 (show CLIP1 Antibodies) causes the accumulation of p150(Glued) (also known as DCTN1) a subunit of dynactin, at microtubule plus ends, thereby facilitating the migration of EGFR (show EGFR Antibodies)-containing endosomes.
The results describe the mutant dynactin p150Glued mouse model of motor neuron disease and show that genetic background influences phenotype in part through a region of chromosome 17 supporting the presence of genetic modifiers.
Dynactin functions as both a dynamic tether and brake during dynein-driven motility.
a mouse model expressing disease linked-G59S mutant dynactin p150(Glued) develops motor dysfunction >8 months before loss of motor neurons or dopaminergic degeneration is observed.
These findings uncovered the surprising functional relevance of GTP-bound Arl3 and LC8 for the unloading regulation of dynactin-bound cargo from dynein motor.
Functional relationships between PIK3C3 (show PIK3C3 Antibodies), dynactin, and AnkB (show ANKH Antibodies) promote axonal transport of organelles and are required for normal axon length.
The direct binding of the dynactin subunit p150(Glued) to JIP1 (show MAPK8IP1 Antibodies) competitively inhibits KHC (show KIF5A Antibodies) activation in vitro and disrupts the transport of APP (show APP Antibodies) in neurons.
These data unveil a previously unrecognized role for the dynein-dynactin motor complex in osteoclast formation and function.
in addition to its ciliogenic roles, Kif3a (show KIF3A Antibodies) recruits p150(Glued) to the subdistal appendages of mother centrioles, critical for centrosomes to function as microtubule-organizing centres.
Overexpression of TBCB (show TBCB Antibodies) leads to the decreased localization of p150 (show ABL1 Antibodies) to the microtubule network that might result in a functional modulation of this protein complex.
Melanoregulin (show MREG Antibodies) interacts with the C-terminal domain of Rab-interacting lysosomal protein (RILP (show RILP Antibodies)) and forms a complex with RILP (show RILP Antibodies) and p150(Glued) (also known as dynactin subunit 1, DCTN1), a component of the dynein-dynactin motor complex.
It was shown KASH5 possesses hitherto unknown KASH-related sequences that directly interacted with SUN1 (show SUN1 Antibodies) and mediated telomere localization. KASH5 interacted with the microtubule-associated dynein- dynactin complex.
Dctn1 plays an important role in mouse spermiogenesis, and mainly affects the formation of the tail of spermatozoa.
This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).
dynactin 1 (p150, glued homolog, Drosophila)
, dynactin P150
, dynactin 1
, dynactin subunit 1
, dynactin subunit 1-like
, 150 kDa dynein-associated polypeptide
, dynactin 1, retrograde axonal transport
, dynactin 1 (p150, glued homolog)