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Kinetochores mature through Ska1 (show SKA1 ELISA Kits)/ska2/Ska3 (show SKA3 ELISA Kits) complex recruitment and this is required for improved load-bearing capacity and silencing of the spindle assembly checkpoint.
p53 (show TP53 ELISA Kits) negatively regulates the expression of the PRR11-SKA2 bidirectional transcription unit through NF-Y, suggesting that the inability to repress the PRR11-SKA2 bidirectional transcription unit after loss of p53 (show TP53 ELISA Kits) might contribute to tumorigenesis.
these data establish the importance of SKA2 for cortisol stress responsivity and the development of post-traumatic stress disorder and provide further evidence that SKA2 is a promising biomarker for stress-related disorders including PTSD.
Results suggest that DNA methylation (show HELLS ELISA Kits)(adj) of SKA2 in blood indexes stress-related psychiatric phenotypes and neurobiology, pointing to its potential value as a biomarker of stress exposure and susceptibility.
DNA methylation (show HELLS ELISA Kits) of the SKA2 gene has been implicated as a biomarker of suicide risk and posttraumatic stress disorder.
SKA2 is hypothesized to reduce the ability to suppress cortisol following stress.
PRR11-SKA2 bidirectional transcription unit, which is a novel direct target of NF-Y, is essential for the accelerated proliferation and motility of lung cancer cells
SKA2 significantly interacted with anxiety and stress to explain about 80% of suicidal behavior and progression from suicidal ideation to suicide attempt.SKA2 is a novel genetic and epigenetic marker involved in the etiology of suicide, suicidal behaviors
The structure of the Ska core complex is a W-shaped dimer of coiled coils, formed by intertwined interactions between Ska1 (show SKA1 ELISA Kits), Ska2, and Ska3 (show SKA3 ELISA Kits).
Data suggest that Aurora B phosphorylation antagonizes the interaction between the Ska1-3 complex and the KMN network, thereby controlling Ska recruitment to KTs and stabilization of KT-MT attachments.
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for ska1 localization (By similarity).
family with sequence similarity 33, member A
, spindle and KT (kinetochore) associated 2
, spindle and kinetochore-associated protein 2
, Protein FAM33A