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Human FGFR1OP Protein expressed in Wheat germ - ABIN1354033
Mano, Takahashi, Ishikawa, Takano, Yasui, Inai, Nishimura, Tsuchiya, Nakamura, Daigo: Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. in Cancer science 2007
This study was designed to determine the association of CCR6 and FGFR10P (tag)single nucleotide polymorphisms with Vogt-Koyanagi-Harada (VKH) syndrome, in two independent Chinese Han populations.
FOP (show ACRV1 Proteins) is a centriolar satellite protein involved in ciliogenesis.
CAP350 interacts directly with FOP (FGFR1 oncogene partner) to form a centrosomal complex required for microtubule anchoring.
a 1.6A resolution crystal structure of the N-terminal dimerization domain of FOP (show ACRV1 Proteins). The structure comprises an alpha-helical bundle composed of two antiparallel chains, each of them having five alpha-helices.
Since FGFR1OP is plays a significant role in lung cancer growth and progression, it may be useful as a prognostic biomarker and as a therapeutic target for lung cancer.
expression of FOP (show CHTOP Proteins)-FGFR1 (show FGFR1 Proteins) in primary bone marrow cells induced by retroviral transduction generates a myeloproliferative disease in mice
This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6\;8)(q27\;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.
FGFR1 oncogene partner
, Fgfr1 oncogene partner
, fibroblast growth factor receptor 1 oncogene partner
, FGFR1 oncogene partner 1