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Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers
Hormad1 and Hormad2 (show HORMAD2 Proteins) might not be the susceptible genes for the non-obstructive azoospermia in our study population. However, rs718772 of Hormad2 (show HORMAD2 Proteins) variant might be associated with testis development in NOA (show DLAT Proteins) patients.
HORMAD1 gene silencing resulted in significantly reduced VEGF protein levels and microvessel density compared to controls in epithelial ovarian carcinoma.
This is the first report showing that HORMAD1 single-nucleotide polymorphisms (SNPs) may predispose men to a defect in spermatogenesis, although the causal and potential mechanistic relationships between these HORMAD1 SNPs and azoospermia remain unclear.
that HORMAD1-IHO1 interaction provides a mechanism for the selective promotion of DNA double-strand break formation along unsynapsed chromosome axes
These results indicate that Hormad1 deficiency promotes DMC1 (show DMC1 Proteins)-independent double-strand break repairs, which in turn helps asynaptic Hormad1(-/-) oocytes resist perinatal loss.
By the analysis of Hormad1/Spo11 (show SPO11 Proteins) double mutants, the Hormad1 deficiency was found to abrogate the massive oocyte loss in the Spo11 (show SPO11 Proteins)-deficient ovary. The Hormad1 deficiency also causes the eventual loss of pseudo sex body in the Spo11 (show SPO11 Proteins)-deficient ovary and testis.
propose that the synaptonemal complex and HORMAD1 are key components of a negative feedback loop that coordinates meiotic progression with homologue alignment: HORMAD1 promotes homologue alignment and synaptonemal-complex formation
HORMAD1 is a critical component of the synaptonemal complex that affects synapsis, recombination, and meiotic sex chromosome inactivation and transcriptional silencing.
HORMAD1 and HORMAD2 (show HORMAD2 Proteins) are depleted from synapsed chromosome axes with the help of TRIP13 (show TRIP13 Proteins).
Results suggest that also mammalian cells use a HORMA domain-containing protein (HORMAD1) as part of a surveillance system that monitors chromosomal synapsis or other interactions between homologs.
The expression pattern of Nohma suggests that it may be a critical regulatory protein in germ cell meiosis.
An octameric model is proposed for the annexin A2 (show ANXA2 Proteins)/p11(S100A10 (show S100A10 Proteins)) complex, which exerts annexin A2 (show ANXA2 Proteins) function. The proposed structure of the annexin A2 (show ANXA2 Proteins)/p11 (show S100A10 Proteins) octamer sheds new light into annexin A2 (show ANXA2 Proteins)/p11 (show S100A10 Proteins) interaction.
This gene encodes a HORMA domain-containing protein. HORMA domains are involved in chromatin binding and play a role in cell cycle regulation. The encoded protein may play a role in meiosis, and expression of this gene is a potential marker for cancer. A pseudogene of this gene is located on the long arm of chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
HORMA domain containing 1
, HORMA domain-containing protein 1-like
, HORMA domain-containing protein 1
, cancer/testis antigen 46
, newborn ovary HORMA protein
, HORMA domain containing protein