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Data (including data from studies using cells cultured from knockout mice) suggest that Sccro (show DCUN1D1 ELISA Kits) neddylates Cul3 (show CUL3 ELISA Kits) with Nedd8 (show NEDD8 ELISA Kits), promoting Cul3 (show CUL3 ELISA Kits)/Klhl21 complex formation and localization of Cul3 (show CUL3 ELISA Kits) during telophase. (Sccro (show DCUN1D1 ELISA Kits) = squamous cell carcinoma-related oncogene; Cul3 (show CUL3 ELISA Kits) = cullin 3 (show CUL3 ELISA Kits); Nedd8 (show NEDD8 ELISA Kits) = neural precursor cell expressed, developmentally down-regulated protein 8; Klhl21 = kelch-like protein 21)
data clearly demonstrate that KLHL21 negatively regulates TNFalpha (show TNF ELISA Kits)-activated NF-kappaB (show NFKB1 ELISA Kits) signaling via targeting IKKbeta (show IKBKB ELISA Kits), providing new insight into the mechanisms underlying NF-kappaB (show NFKB1 ELISA Kits) regulation in cells.
Our study suggests that KLHL21 is a potential target for therapeutic intervention. Our findings also provide novel candidate genes on a genome-wide scale, which may have significant impact on the design and execution of effective therapy of HCC (show FAM126A ELISA Kits) patients.
KLHL21 localizes to midzone microtubules in anaphase & recruits aurora B (show AURKB ELISA Kits) & Cul3 (show CUL3 ELISA Kits) to this region; results suggest that different Cul3 (show CUL3 ELISA Kits) adaptors nonredundantly regulate aurora B (show AURKB ELISA Kits) during mitosis, possibly by ubiquitinating different pools of aurora B (show AURKB ELISA Kits)
Substrate-specific adapter of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity).
kelch-like protein 21
, kelch-like 21 (Drosophila)
, kelch-like 21