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Browse our KPNA2 Proteins (KPNA2)

Full name:
Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) Proteins (KPNA2)
On www.antibodies-online.com are 12 Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) Proteins from 7 different suppliers available. Additionally we are shipping KPNA2 Antibodies (108) and KPNA2 Kits (9) and many more products for this protein. A total of 137 KPNA2 products are currently listed.
Synonyms:
2410044B12Rik, AW146299, Gm1055, ima2, importin, IPOA1, PTAC58, QIP2, RCH1, SRP1alpha
list all proteins Gene Name GeneID UniProt
KPNA2 16647 P52293
Rat KPNA2 KPNA2 85245  
KPNA2 3838 P52292

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KPNA2 Proteins (KPNA2) by Origin

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Top referenced KPNA2 Proteins

  1. Human KPNA2 Protein expressed in Escherichia coli (E. coli) - ABIN667661 : Braem, Kas, Meyen, Debiec-Rychter, Van De Ven, Voz: Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal. in The Journal of biological chemistry 2002 (PubMed)
    Show all 2 references for ABIN667661

  2. Human KPNA2 Protein expressed in Wheat germ - ABIN1308916 : Wang, Wang, Wang, Chen, Wu, Liang, Tsai, Chang, Yu, Yu: Importin subunit alpha-2 is identified as a potential biomarker for non-small cell lung cancer by integration of the cancer cell secretome and tissue transcriptome. in International journal of cancer. Journal international du cancer 2011 (PubMed)

More Proteins for KPNA2 Interaction Partners

Xenopus laevis Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) interaction partners

  1. Nuclear import rates correlated with nuclear size, and varying the concentrations of two transport factors, importin alpha (show KPNA4 Proteins) and Ntf2 (show NUTF2 Proteins), was sufficient to account for nuclear scaling between the two species.

Mouse (Murine) Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) interaction partners

  1. Results demonstrated that radiation-induced dying colorectal cancer cells released considerable amounts of KPNA2 that induce the maturation and activation of DCs for synergistic antitumor effect of radiation.

  2. mTORC1 positively regulated the importer protein KPNA2, which participated in glycolysis regulation downstream of mTORC1 in a HIF1alpha (show HIF1A Proteins)-independent manner, indicating that mTORC1 regulates glycolysis through multiple ways.

  3. provided support for a link between autophagy and epithelial-to-mesenchymal (-like) transition status in WT TP53 (show TP53 Proteins) glioblastoma cells and provided evidence for the signaling pathway (MIR517C-KPNA2-cytoplasmic TP53 (show TP53 Proteins)) involved in attenuating autophagy

  4. Structure of importin-alpha (show KPNA4 Proteins) bound to a non-classical nuclear localization signal of the influenza A virus nucleoprotein has been reported.

  5. Specific interaction with the nuclear transporter (show RPAIN Proteins) importin (show KPNA4 Proteins) alpha2 can modulate paraspeckle protein 1 (show PSPC1 Proteins) delivery to nuclear paraspeckles.

  6. constitutive expression of Kpna2 during the differentiation culture of ESCs (show NR2E3 Proteins) significantly impairs clock development, and KPNA2 facilitates cytoplasmic localization of PER1 (show PER1 Proteins)/

  7. a significant correlation of KPNA2 expression and tumour aggressiveness in a large variety of other solid tumour entities

  8. study reports a cell-fate determination mechanism in which importin (show KPNA4 Proteins) alpha2 negatively regulates the nuclear import of certain transcription factors to maintain embryonic stem cell properties

  9. importin alpha (show KPNA4 Proteins) binds to Nup153 (show NUP153 Proteins)

  10. results collectively reveal that nuclear-localized importin (show KPNA4 Proteins) alpha2 influences gene expression and contributes directly to cell fate outcomes including non-apoptotic cell death.

Human Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) interaction partners

  1. p53 (show TP53 Proteins)/p21Cip1/Waf1 (show CDKN1A Proteins)/p16INK4a may be an important pathway involved in the function of KPNA2 in tongue squamous cell carcinoma (TSCC) CAL (show FBLIM1 Proteins)-27 cells.

  2. Results demonstrated that radiation-induced dying colorectal cancer cells released considerable amounts of KPNA2 that induce the maturation and activation of DCs for synergistic antitumor effect of radiation.

  3. These results suggest that the selected aptamers (76 and 72) warrant further study to explore not only their application in cancer diagnosis but also their use as a specific reagent to potentially block KPNA2-dependent nuclear transport of macromolecules across the nuclear membrane.

  4. anti-importin (show KPNA4 Proteins) alpha1 antibody treatment suppressed the importin (show KPNA4 Proteins) alpha1-FGF1 (show FGF1 Proteins) complex formation and ERK1/2 activation, resulting in decreased cell growth. This study provides novel evidence that functional importin (show KPNA4 Proteins) alpha1 is located at the cell surface, where it accelerates the proliferation of cancer cells.

  5. The combination of low nuclear and cytoplasmic KPNA2 expression is associated with adverse outcome in head and neck squamous cell carcinoma treated with radio(chemo)therapy.

  6. provided support for a link between autophagy and epithelial-to-mesenchymal (-like) transition status in WT TP53 (show TP53 Proteins) glioblastoma cells and provided evidence for the signaling pathway (MIR517C-KPNA2-cytoplasmic TP53 (show TP53 Proteins)) involved in attenuating autophagy

  7. Suggest that KPNA2 may play a key role in the inflammation process of rheumatoid arthritis via NF-kappaB (show NFKB1 Proteins) P65 (show GORASP1 Proteins) signal transduction pathway.

  8. KPNA2 might play an important role in colorectal carcinogenesis and functions as a novel prognostic indicator and a potential therapeutic target for colorectal cancer.

  9. High KPNA2 expression was found to be associated with poor prognosis and resistance to hyperthermochemoradiation therapy (HCRT).

  10. RBBP4 (show RBBP4 Proteins) functions as a novel regulatory factor to increase the efficiency of importin alpha (show KPNA4 Proteins)/beta-mediated nuclear import

Pig (Porcine) Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) interaction partners

  1. Authors demonstrated that swine importin (show KPNA4 Proteins) alpha1 interacts with the M1 protein and transports it to the nucleus.

KPNA2 Protein Profile

Protein Summary

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination

Alternative names and synonyms associated with KPNA2

  • importin subunit alpha-2 (EDI_246290)
  • importin subunit alpha-2 (EDI_335040)
  • Importin subunit alpha-2 (ima2)
  • importin alpha 1b (kpna2)
  • karyopherin (importin) alpha 2 (Kpna2)
  • karyopherin alpha 2 (Kpna2)
  • karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2)
  • karyopherin alpha 7 (importin alpha 8) (Kpna7)
  • 2410044B12Rik protein
  • AW146299 protein
  • Gm1055 protein
  • ima2 protein
  • importin protein
  • IPOA1 protein
  • PTAC58 protein
  • QIP2 protein
  • RCH1 protein
  • SRP1alpha protein

Protein level used designations for KPNA2

importin subunit alpha-2 , Importin subunit alpha-2 , karyopherin subunit alpha-2 , RAG cohort protein 1 , SRP1-alpha , importin alpha P1 , importin subunit alpha-1 , m-importin-alpha-P1 , pendulin , pore targeting complex 58 kDa subunit , karyopherin (importin) alpha 2 , nuclear import protein , RAG cohort 1 , importin alpha 1 , importin alpha 2 , importin-alpha-P1 , importin subunit alpha-8 , karyopherin subunit alpha-7 , nuclear transport receptor

GENE ID SPECIES
5881743 Entamoeba dispar SAW760
5886378 Entamoeba dispar SAW760
100195132 Salmo salar
398027 Xenopus laevis
16647 Mus musculus
85245 Rattus norvegicus
3838 Homo sapiens
480469 Canis lupus familiaris
397218 Sus scrofa
513592 Bos taurus
381686 Mus musculus
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