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our data point to the existence of a functional interplay between hMSH5 and FANCJ (show BRIP1 ELISA Kits) in double-strand break repair induced by replication stress.
the roles of hMSH5 variants in the processes of DNA damage response and repair
Authors show that MSH5 (MutSHomolog 5) is localized into the mitochondria of germ and somatic cells.
Study has suggested a role for hMSH5 in the processing of cisplatin-induced DSBs, and silencing of hMSH5 may provide a new means to improve the therapeutic efficacy of cisplatin.
The presence of the MSH5 85F allele marks the subgroup of DRB1 (show RBM45 ELISA Kits)*0102 haplotypes carrying susceptibility for selective IgA deficiency. MSH5 polymorphisms per se are not predisposing factors.
hMSH5 possesses a CRM1 (show XPO1 ELISA Kits)-dependent nuclear export signal and a nuclear localization signal that participates to its nuclear targeting.
There is an association of polymorphism C85T in MSH5 or C2531T in MLH3 with male infertility, specifically azoospermia or severe oligozoospermia, and interaction between these MSH5 and MLH3 polymorphisms increased the risk of developing male infertility
The different properties associated with these two hMSH5 variants underscore the potential functional diversity of the human hMSH5 gene.
the GPS2 (show GPS2 ELISA Kits) might function in concert with hMSH4-hMSH5 during the process of homologous recombination.
A review of the properties and functional roles of MSH5.
These findings suggest that Msh4/5 heterodimers contribute to class switch recombination.
Immunohistochemical analysis revealed the co-localization of SMCY (show KDM5D ELISA Kits) with MSH5 (show HSPA1L ELISA Kits) at a specific stage of meiotic prophase progression during murine spermatogenesis.
Results reported in this study indicate that Msh5 (show HSPA1L ELISA Kits) does not have a role in immunoglobulin class switch recombination.
Results report a specific role for IFE-2 in a conserved temperature-sensitive meiotic process that results in an increase in MSH-5 protein levels.
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene.
mutS homolog 5 (E. coli)
, mutS homolog 5-like
, mutS protein homolog 5-like
, mutS homolog 5
, mutS protein homolog 5
, mutS-like protein 5
, DNA mismatch repair protein Msh5