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GRAF1 (show ARHGAP26 ELISA Kits)-mediated removal of Rab8 from the cell surface restricts its activity during protrusion formation, thereby facilitating dynamic adjustment of the polarity axis.
the TNPO1 (show TNPO1 ELISA Kits)-Rab8-ciliary targeting signals complex mediates selective entry into and retention of cargos within cilia.
Ectopic expression of an N-terminal-truncated ARHGEF10 (show ARHGEF10 ELISA Kits) mutant led to the generation of large vesicle-like structures containing both Rab6 (show RAB6A ELISA Kits) and Rab8.
report the design of a bioavailable StRIP3 analogue that harbors two hydrophobic cross-links and exhibits increased binding affinity, combined with robust cellular uptake and extremely high proteolytic stability. Localization experiments reveal that this double-stapled peptide and its target protein Rab8a accumulate in the same cellular compartments
knockdown of another Parkinson's disease (PD) gene, LRRK2 (show LRRK2 ELISA Kits), which phosphorylates Rab8a, similarly impairs retromer trafficking, secretory autophagy and Golgi-derived vesicle secretion, thus demonstrating converging roles of two PD genes TMEM230 and LRRK2 (show LRRK2 ELISA Kits) on Rab8a function, and suggesting that retromer and secretory dysfunction play an important role in PD pathogenesis.
Rab8 can induce Rac1- and Tiam1-dependent cortical actin polymerization and focal adhesion disassembly through the proteases MT1-MMP (show MMP14 ELISA Kits) and calpain, and Rho-GTPase (show RACGAP1 ELISA Kits)-dependent mechanisms
Data demonstrate that EHBP1L1 links Rab8 and the Bin1 (show BIN1 ELISA Kits)-dynamin (show DNM1 ELISA Kits) complex, which generates membrane curvature and excises the vesicle at the endocytic recycling compartment for apical transport.
Further exploration of the NINL-associated interactome identifies MICAL3, a protein known to interact with Rab8 and to play an important role in vesicle docking and fusion.
The small GTPase (show RACGAP1 ELISA Kits) Rab8 interacts with VAMP-3 (show VAMP3 ELISA Kits) to regulate the delivery of recycling T-cell receptors to the immune synapse.
the role of Rabin8 (a mammalian ortholog of Sec2p) with Rab8-nucleotide-exchange factor activity in autophagy in mammalian cells, was examined.
Cc2d2a (show CC2D2A ELISA Kits), localized at the photoreceptor connecting cilium/transition zone, facilitates protein transport through a role in Rab8-dependent vesicle trafficking and fusion.
Data show that elipsa (show TRAF3IP1 ELISA Kits) encodes a coiled-coil polypeptide that localizes to cilia, and that it interacts genetically with Rabaptin5, a well-studied regulator of endocytosis, which in turn interacts with Rab8, a small GTPase (show RACGAP1 ELISA Kits), known to localize to cilia.
The small GTPase (show RACGAP1 ELISA Kits) Rab8a regulates lipid uptake and storage in skeletal muscle.
Rab8a and Rab11a (show RAB11A ELISA Kits) Are Dispensable for Rhodopsin (show RHO ELISA Kits) Transport in Mouse Photoreceptors
With CRISPR/Cas9-mediated gene editing to stably knock out and recover Rab8a in macrophage cell lines, this study matches Akt (show AKT1 ELISA Kits) signaling profiles with cytokine outputs, confirming that Rab8a is a novel regulator of the Akt (show AKT1 ELISA Kits)/mammalian target of rapamycin (mTOR (show FRAP1 ELISA Kits)) pathway downstream of multiple Toll (show TLR4 ELISA Kits)-like Receptors.
these results indicate an indispensable role for Rab8A in insulin (show INS ELISA Kits)-regulated GLUT4 (show SLC2A4 ELISA Kits) trafficking in C2C12 cells.
Results highlight a novel role of Rab8, downstream of IFT20, in the pathway that regulates T cell receptor (TCR) recycling, through recruiting VAMP-3 and promoting the fusion with the synaptic membrane of endosomes carrying TCR cargoes.
Rab8a thus controls Wnt (show WNT2 ELISA Kits) delivery in producing cells and is crucial for Paneth cell maturation.
Rab8a acts as an activator of Fsp27 (show CIDEC ELISA Kits)-mediated LD fusion and growth.
Simultaneous loss of Rab8a and Rab8b (show RAB8B ELISA Kits) has little effect on ciliogenesis, whereas additional loss of Rab10 (show RAB10 ELISA Kits) greatly affects ciliogenesis.
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.
, hematopoietic SH2 domain containing
, ras-related protein Rab-8A
, RAB8A, member RAS oncogene family
, member RAS oncogene family
, Ras-related protein Rab-8A
, mel transforming oncogene (RAB8 homolog)
, mel transforming oncogene (derived from cell line NK14)
, mel transforming oncogene (derived from cell line NK14)- RAB8 homolog
, oncogene c-mel
, ras-associated protein RAB8
, RAB8, member RAS oncogene family
, cell line NK14 derived transforming oncogene