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several analyses of vesicular transport demonstrated that Rab6A (show RAB6A ELISA Kits) and BICD2 play crucial roles in Golgi tubule fusion with the endoplasmic reticulum (ER) in brefeldin A (BFA)-treated cells
the features of BICD2 spinal muscular atrophy, lower extremity predominant are consistent with a pathological process that preferentially affects lumbar lower motor neurons
Mutations in BICD2 cause congenital autosomal-dominant spinal muscular atrophy and massive Golgi fragmentation in affected cells.
BICD2 mutations cause non-5q linked spinal muscular atrophy in humans
Disease causing mutations resulting in amino acid substitutions in two binding regions of BICD2 increase its binding affinity for the cytoplasmic dynein (show DYNC1H1 ELISA Kits)-dynactin (show DCTN1 ELISA Kits) complex.
Data suggest that ASUN promotes perinuclear enrichment of dynein at G2/M that facilitates BICD2- and CENP-F-mediated anchoring of dynein to nuclear pore complexes.
isolation, cloning, and characterization of human Nek8 (show NEK9 ELISA Kits), a new mammalian NIMA-related kinase, and its candidate substrate Bicd2
Data indicate that Bicaudal-D2 (BICD2)-deficient mice develop disrupted laminar organization of cerebral cortex and the cerebellum, pointing to impaired radial neuronal migration.
LIS1 (show PAFAH1B1 ELISA Kits) is required for dynein-mediated transport induced by membrane tethering of BICD2-N and LIS1 (show PAFAH1B1 ELISA Kits) contributes to dynein accumulation at microtubule plus ends and BICD2-positive cellular structures.
BICD2-N transgene increased lifespan in 'low copy' SOD1-G93A ALS transgenic mice.
This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described.
protein bicaudal D homolog 2
, bicaudal D homolog 2 (Drosophila)
, bicaudal D homolog 2
, protein bicaudal D homolog 2-like
, bic-D 2
, coiled-coil protein BICD2
, cytoskeleton-like bicaudal D protein homolog 2
, homolog of Drosophila bicaudal D
, bicaudal D protein