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The integrity of the mitotic checkpoint complex depends on the specific recognition between BubR1 (show BUB1B ELISA Kits) and Bub3, for which the BubR1 (show BUB1B ELISA Kits) Gle2 (show RAE1 ELISA Kits) binding sequence motif is essential.
We show that kinetochore recruitment of BUBR1 (show BUB1B ELISA Kits) and BUB3 by BUB1 (show BUB1 ELISA Kits) is dispensable for SAC (show ADCY10 ELISA Kits) activation
a mutual antagonism exists between Bub3 and dynein to ensure optimal KT-MT attachments
the mechanisms of BUB3 in mitotic checkpoint signaling
Data show sequential multisite regulation of the microtubule-associated protein KNL1 (show CASC5 ELISA Kits)-kinase-adaptor complex BUB1 (show BUB1 ELISA Kits)/BUB3 interaction.
Data indicate that cell cycle protein Bub3-mediated kinetochore recruitment of BubR1 (show BUB1B ELISA Kits) kinase enhances mitotic checkpoint signaling.
Results suggest that these USP7 (show USP7 ELISA Kits)-dependent effects are mediated by decreased levels of spindle assembly checkpoint (SAC (show ADCY10 ELISA Kits)) component Bub3.
Mutations targeting the Bub3 interface prevent kinetochore recruitment of the SAC (show ADCY10 ELISA Kits) kinase Bub1 (show BUB1 ELISA Kits). Crucially, they also cause a checkpoint defect, showing that recognition of phosphorylated targets by Bub3 is required for checkpoint signaling
Results showed that neither variants in BUB3 nor variants in MAD2L1 (show MAD2L1 ELISA Kits) caused any significant effect on the risk of breast cancer
Mutations in BUB1 (show BUB1 ELISA Kits) and BUB3 cause mosaic variegated aneuploidy and increase the risk of colorectal cancer at a young age.
as a member of the spindle assembly checkpoint, Bub3 is required for regulation of both meiosis I and II, and is potentially involved in kinetochore-microtubule attachment in mammalian oocytes
Cenpa (show CENPA ELISA Kits), Cenpb (show CENPB ELISA Kits), and Bub3, but not Cenpc (show CENPC1 ELISA Kits), interacted with PARP-1 (show PARP1 ELISA Kits)
Haploinsufficiency of Bub3 causes a slight increase in chromosome instability but is not clearly associated with a noticeable rise in the probability of tumor formation.
subpopulation of dynein, containing the DYNLT3 (show DYNLT3 ELISA Kits) light chain, may be important for chromosome congression, in addition to having a role in the transport of checkpoint proteins from the kinetochore to the spindle pole
This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
BUB3 budding uninhibited by benzimidazoles 3 homolog
, budding uninhibited by benomyl
, budding uninhibited by benzimidazoles 3 homolog
, mitotic checkpoint component
, mitotic checkpoint protein BUB3
, WD repeat protein Bub3
, WD repeat type I transmembrane protein A72.5