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Browse our CASC5 (CASC5) ELISA Kits

Full name:
Cancer Susceptibility Candidate 5 ELISA Kits (CASC5)
On www.antibodies-online.com are 0 Cancer Susceptibility Candidate 5 (CASC5) ELISA Kits from different suppliers available. Additionally we are shipping CASC5 Antibodies (44) and and many more products for this protein. A total of 47 CASC5 products are currently listed.
Synonyms:
2310043D08Rik, 5730505K17Rik, AF15Q14, CT29, D40, hKNL-1, hSpc105, KNL1, PPP1R55, Rad51, Spc7
list all ELISA KIts Gene Name GeneID UniProt
Human CASC5 CASC5 57082 Q8NG31
Mouse CASC5 CASC5 76464  
Rat CASC5 CASC5 311327  

Show all synonyms

More ELISA Kits for CASC5 Interaction Partners

Human Cancer Susceptibility Candidate 5 (CASC5) interaction partners

  1. Involvement of CASC5 in autosomal recessive microcephaly and a founder effect of the c.6125G>A mutation.

  2. Targeted Knockdown of the Kinetochore Protein D40/Knl-1 Inhibits Human Cancer in a p53 (show TP53 ELISA Kits) Status-Independent Manner

  3. We propose that CASC5 has a key role for the correct functioning of DNA damage response proteins, and a defect in this connection might affect upstream and downstream DNA damage response events as response to increased genotoxic stress.

  4. Data show sequential multisite regulation of the microtubule-associated protein KNL1-kinase-adaptor complex BUB1 (show BUB1 ELISA Kits)/BUB3 (show BUB3 ELISA Kits) interaction.

  5. Mechanisms of mitosis-specific assembly of the checkpoint platform Knl1/MIS12 (show MIS12 ELISA Kits)/NDC80 (show NDC80 ELISA Kits) at human kinetochores.

  6. PP2A (show PPP2R4 ELISA Kits)-B56 is a key phosphatase for the removal of the Mps1 (show IDUA ELISA Kits)-mediated Knl1 phosphorylations necessary for Bub1/BubR1 (show BUB1B ELISA Kits) recruitment in mammalian cells.

  7. Protein phosphatase 1 (PP1) binding to KNL1 during prometaphase reduces the levels of Bub proteins at kinetochores to approximately the level recruited by four active MELT repeats.

  8. In cells depleted of endogenous Knl1, kinetochore-targeted Knl1(1-250) suffices to restore spindle assembly checkpoint and chromosome alignment

  9. KNL1 contains an extensive array of short linear sequence modules that encompass TxxOmega and MELT motifs and that can independently localize BUB1 (show BUB1 ELISA Kits).

  10. KNL1 is a requirement for Aurora B (show AURKB ELISA Kits) activity at kinetochores and for wild-type kinetochore-MT attachment dynamics.

Caenorhabditis elegans (C. elegans) Cancer Susceptibility Candidate 5 (CASC5) interaction partners

  1. Data indicate that microtubule-associated proteins KNL-1 oligomerization may coordinate with other kinetochore activities to ensure the proper organization, function, and sensory capabilities of the kinetochore-microtubule attachment.

  2. KNL-1 plays a central role in translating the initiation of kinetochore assembly

CASC5 Antigen Profile

Antigen Summary

The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11\;15)(q23\;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed.

Alternative names and synonyms associated with CASC5

  • cancer susceptibility candidate 5 (CASC5) Elisa Kit
  • cancer susceptibility candidate 5 (Casc5) Elisa Kit
  • Protein KNL-1 (knl-1) Elisa Kit
  • 2310043D08Rik Elisa Kit
  • 5730505K17Rik Elisa Kit
  • AF15Q14 Elisa Kit
  • CT29 Elisa Kit
  • D40 Elisa Kit
  • hKNL-1 Elisa Kit
  • hSpc105 Elisa Kit
  • KNL1 Elisa Kit
  • PPP1R55 Elisa Kit
  • Rad51 Elisa Kit
  • Spc7 Elisa Kit

Protein level used designations for CASC5

cancer susceptibility candidate 5 , ALL1-fused gene from chromosome 15q14 protein , blinkin, bub-linking kinetochore protein , cancer susceptibility candidate gene 5 protein , cancer/testis antigen 29 , kinetochore null 1 homolog , kinetochore-null protein 1 , protein CASC5 , protein phosphatase 1, regulatory subunit 55 , RAD51 homolog

GENE ID SPECIES
100071354 Equus caballus
423007 Gallus gallus
57082 Homo sapiens
76464 Mus musculus
311327 Rattus norvegicus
478260 Canis lupus familiaris
787969 Bos taurus
176164 Caenorhabditis elegans
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