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This study reveals clear genetic-statistical evidence for a link of KRT8 (show KRT8 Proteins), FAF1 and PTH1R (show PTH1R Proteins) with some of leg weakness related traits in pigs.
FAF1 plays a novel role in negatively regulating virus-induced IFN-beta (show IFNB1 Proteins) production and the antiviral response by inhibiting the translocation of active, phosphorylated IRF3 (show IRF3 Proteins) from the cytosol to the nucleus
Progression of the DNA replication fork is coordinated by FAF1. FAF1 binds to the licensing factor CDT-1 (show CDT1 Proteins) and additional ubiquitylated proteins, thus promoting CDC48 (show vcp Proteins)-dependent turnover and disassembly of DNA replication factor (show CDT1 Proteins) complexes.
Report a novel role for FAF1 in regulating CD40-induced NFkappaB activation via a negative feedback loop.
The repertoire of VAPB (show VAPB Proteins) interactors is more diverse than previously anticipated and link VAPB (show VAPB Proteins) to the function of ATPase complexes such as p97 (show EIF4G2 Proteins)/FAF1 and ASNA1 (show ASNA1 Proteins)/transmembrane-domain recognition complex.
long-chain unsaturated fatty acids also induced polymerization of Fas-associated factor 1 (FAF1), the only other mammalian protein that contains a UAS domain homologous to that of Ubxd8 (show FAF2 Proteins)
Data indicate that Npl4-Ufd1 (show UFD1L Proteins) heterodimer is required for VCP (show vcp Proteins)-FAF1 interaction.
hFAF1 inhibits tumor formation by increasing the degradation of Hsp70 (show HSP70 Proteins) mediated via its UBA domain.
Fas-associated factor 1 is a scaffold protein (show HOMER1 Proteins) that promotes beta-transducin repeat-containing protein (beta-TrCP (show BTRC Proteins))-mediated beta-catenin (show CTNNB1 Proteins) ubiquitination and degradation.
Wild-type p97/VCP (show vcp Proteins) ND1 (show MT-ND1 Proteins) in complex with FAF1 UBX crystallized into very thin sheet-shaped crystals which turned out to be of poor diffraction quality
The authors report the first in vitro confirmed non-homotypic interaction between NLRP12 (show NLRP12 Proteins) pyrin (show MEFV Proteins) domain and the pro-apoptotic protein Fas-associated factor 1 (FAF-1), which links the innate immune system to apoptotic signaling.
Increased FAF1 expression triggers caspase-3 (show CASP3 Proteins) cleavage and activation, leading to hyperphosphorylated tau aggregation and subsequent neurofibrillary tangles formation, in turn initiating apoptosis.
Taken together, these results suggest a new role for FAF1: that of a positive modulator for Parkinson's disease .
FAF1 is a novel inhibitory factor of canonical Wnt (show WNT2 Proteins) signaling pathway
Capsaicin-induced cancer cell apoptosis involves FAF1, a TRPV1 (show TRPV1 Proteins) associated protein.
Analysis of FAF1 expression revealed that the protein is present in early preimplantation stages, while embryonic expression of Faf1 mRNA becomes appreciable at 4-cell stage.
Data show that Faf1 protein level is down-regulated during apoptosis in a caspase-3 (show CASP3 Proteins)- and Apaf1 (show APAF1 Proteins)-dependent manner.
analysis of the negative feedback regulation of Aurora-A (show AURKA Proteins) via phosphorylation of Fas-associated factor-1
Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain.
Fas (TNFRSF6) associated factor 1
, FAS-associated factor 1
, FAS-associated factor 1-like
, TNFRSF6-associated factor 1
, UBX domain protein 3A
, UBX domain-containing protein 12
, UBX domain-containing protein 3A